Results 61 to 70 of about 17,762 (221)

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Re-characterization of the Glomerulopathy in CD2AP Deficient Mice by High-Resolution Helium Ion Scanning Microscopy

Scientific Reports, 2017
Helium ion scanning microscopy (HIM) is a novel technology that directly visualizes the cell surface ultrastructure without surface coating. Despite its very high resolution, it has not been applied extensively to study biological or pathology samples ...
Kenji Tsuji, Teodor G. Păunescu, Hani Suleiman, Dongping Xie, Fahmy A. Mamuya, Jeffrey H. Miner, Hua A. Jenny Lu   +6 more
doaj   +1 more source

CAFE: Calar Alto Fiber-fed Echelle spectrograph

, 2013
We present here CAFE, the Calar Alto Fiber-fed Echelle spectrograph, a new instrument built at the Centro Astronomico Hispano Alem\'an (CAHA). CAFE is a single fiber, high-resolution ($R\sim$70000) spectrograph, covering the wavelength range between 3650-
Aceituno, J., Barrado, D., Bean, J., Benitez, D., Dreizler, S., Grupp, F., Hernan-Obispo, M., Lillo, J., Montoya, L. M., Pedraz, S., Sanchez, S. F., Thiele, U.   +11 more
core   +1 more source

Podocin Localizes in the Kidney to the Slit Diaphragm Area [PDF]

The American Journal of Pathology, 2002
We recently cloned a novel gene, NPHS2, involved in autosomal recessive steroid-resistant nephrotic syndrome. This gene encodes a novel podocyte protein, podocin. Given its similarity with the stomatin family proteins, podocin is predicted to be an integral membrane protein with a single membrane domain forming a hairpin-like structure placing both N ...
Séverine, Roselli, Olivier, Gribouval, Nicolas, Boute, Mireille, Sich, France, Benessy, Tania, Attié, Marie-Claire, Gubler, Corinne, Antignac   +7 more
openaire   +2 more sources

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

The isoporous substructure of the human glomerular slit diaphragm

Kidney International, 1975
The substructure of the human glomerular slit diaphragm is examined after perfusion fixation of a human kidney with tannic acid-glutaraldehyde. The present study shows that the substructure of the slit diaphragm in man is very similar to that described in rats and mice, and that the dimensions of the contained pores (50 times 120 A) in the human differ
Schneeberger, Eveline E., Levey, Raphael H., McCluskey, Robert T., Karnovsky, Morris J.   +3 more
openaire   +2 more sources

Laser‐Architected Shape‐Configurable Vertical Graphene Thermoacoustic Loudspeakers for 3D Acoustic Emission

Advanced Science, EarlyView.
A dual‐laser‐architected vertical graphene film enables high‐performance, morphologically reconfigurable thermoacoustic loudspeakers.The vertically aligned graphene structures combine efficient heat dissipation, thickness‐independent SPL, and kirigami‐driven 3D transformations, offering shape‐programmable, stretchable, and omnidirectional acoustic ...
TaeGyeong Lim, Se Young Lee, Dohyung Lee, Baek Heon Lim, Jeongbo Lee, Wooseok Song, Sun Sook Lee, Sungwoong Park, Jin Kim, Soonmin Yim, Ki‐Seok An, Saewon Kang   +11 more
wiley   +1 more source

A Compact, High‐Performance, and Deformation‐Resilient Trielectrode Electrostatic Soft Pump for Soft Robotics

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Existing soft pumps often require tradeoffs between performance and compatibility with soft robotic systems. The proposed trielectrode electrostatic soft pump addresses these limitations through an innovative driving mechanism. Its design, which includes a trielectrode configuration and the use of compliant materials, improves operational efficiency ...
Yangqiao Lin, Xiaoli Yang, Tao Jin, Jieyu Wang, Sicheng Yi, Yue Wang, Songyi Zhong, Tao Yue, Quan Zhang, Yingzhong Tian, Long Li   +10 more
wiley   +1 more source

Argon Cold Plasma Modification of Polyethylene Films to Tailor Surface and Barrier Properties

Journal of Applied Polymer Science, EarlyView.
Argon cold plasma treatment of low‐density polyethylene (LDPE) and high‐density polyethylene (HDPE) films induces major changes in surface chemistry and morphology. Contact angles decrease significantly while surface energy increases, improving wettability. FTIR confirms the formation of polar functional groups, while pronounced etching, roughness, and
Aikaterini Spanou, Chrysi Lagkouvardou, Petrina Vogiannou, Vasiliki Korka, Enrico Maurizzi, Ioanna Georgia I. Athanasoulia, Dimitrios Ladakis, Andrea Pulvirenti, Efstathios Z. Panagou, Demetres Briassoulis, Apostolis Koutinas, Theofania Tsironi   +11 more
wiley   +1 more source

Renal Effects and Underlying Molecular Mechanisms of Long-Term Salt Content Diets in Spontaneously Hypertensive Rats. [PDF]

PLoS ONE, 2015
Several evidences have shown that salt excess is an important determinant of cardiovascular and renal derangement in hypertension. The present study aimed to investigate the renal effects of chronic high or low salt intake in the context of hypertension ...
Rebeca Caldeira Machado Berger, Paula Frizera Vassallo, Renato de Oliveira Crajoinas, Marilene Luzia Oliveira, Flávia Letícia Martins, Breno Valentim Nogueira, Daisy Motta-Santos, Isabella Binotti Araújo, Ludimila Forechi, Adriana Castello Costa Girardi, Robson Augusto Souza Santos, José Geraldo Mill   +11 more
doaj   +1 more source