Results 61 to 70 of about 217,308 (243)
Renal Failure, 2023 Diabetic kidney disease (DKD) is a primary cause of end-stage renal disease. Proteinuria is a clinical indicator of the different stages of DKD, and podocyte injury is a major cause of proteinuria.
Le Gong +7 more
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Lipid–Protein Interactions along the Slit Diaphragm of Podocytes [PDF]
Journal of the American Society of Nephrology, 2009 Podocytes are visceral epithelial cells supporting the function of the glomerular filter. Interdigitating foot processes of podocytes enwrap the glomerular capillaries and are connected by a highly specialized cell junction, the slit diaphragm. Signal transduction at the slit diaphragm is essential for the proper function of the kidney filtration ...
Bernhard, Schermer, Thomas, Benzing
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PLoS ONE, 2013 Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. Especially, the highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. This is highlighted by the
Zhijie Xiao +5 more
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Kif21a deficiency leads to impaired glomerular filtration barrier function
Scientific Reports, 2023 The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and a number of other functions such as metabolic waste elimination and the regulation of water, electrolyte and acid–base balance.
Hanna Riedmann +4 more
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Structural continuity of filtration slit (slit diaphragm) to plasma membrane of podocyte
Kidney International, 1996 Murine monoclonal antibody 5-1-6 was reported to bind to the slit membrane and closely related structures in rat renal glomeruli; it induced heavy, reversible proteinuria and appeared to redistribute onto the plasma membrane of epithelial cells after binding at the original target sites.
Fujigaki, Yoshihide +8 more
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Current concepts of the podocyte in nephrotic syndrome
Kidney Research and Clinical Practice, 2012 Nephrotic syndrome is a disorder of the glomerular filtration barrier, and central to the filtration mechanism of the glomerular filtration barrier is the podocyte.
Wen Y. Ding, Moin A. Saleem
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New perspectives on the renal slit diaphragm protein podocin [PDF]
Modern Pathology, 2011 Podocin is a critical component of the glomerular filtration barrier, its mutations causing recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (NPHS2) gene resulted in the possible existence of a new splice variant of podocin in the kidney, missing the in-frame of exon 5, encoding the prohibitin homology domain ...
Relle, Manfred +6 more
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Morphine induces albuminuria by compromising podocyte integrity.
PLoS ONE, 2013 Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear.
Xiqian Lan +11 more
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Genetic Basis of Steroid Resistant Nephrotic Syndrome [PDF]
Childhood Kidney Diseases, 2019 Steroid-resistant nephrotic syndrome (SRNS) has long been a challenge for clinicians due to its poor responsiveness to immunosuppressants, and rapid progression to end-stage renal disease.
Eujin Park
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Kidney InternationalPodocytopathies represent a group of glomerular disorders associated with minimal changes (MC) or focal segmental glomerulosclerosis (FSGS) lesion patterns at biopsy and heterogeneous responses to steroids.
Valentina Raglianti +25 more
semanticscholar +1 more source