Results 51 to 60 of about 165,371 (351)

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications

Diagnostics, 2023
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway.
Qi Wang, Fei Xiong, Guanhua Wu, Da Wang, Wenzheng Liu, Junsheng Chen, Yongqiang Qi, Bing Wang, Yongjun Chen   +8 more
doaj   +1 more source

A Hunting Account [PDF]

, 2009
O rgyan dban phyugs provides a personal account of huntingThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad Village and Ri sne
Bkra shis bzang po
core  

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]

, 2020
The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez, A Woods, AR Ramjaun, AY Hsing, B Bierie, B Ozdamar, B-C Kim, BR Binder, C Allan, CJ David, CS Hill, DB Shackelford, EC Connolly, FA Ran, G Avery-Cooper, G Rena, G Rosti, GD Cuny, GJ Inman, GJ Inman, GM Keating, H Ikushima, J Massagué, J Massagué, J Massaous, J Ozanne, J Song, J Vogt, J Xu, JF Callahan, JL Wrana, JM Lizcano, Joan Massagué, JY Altarejos, K Clark, KA Brown, KJ Livak, LC Spender, LC Spender, M Abe, M Kowanetz, M Tojo, MO Li, MR Keeton, NJ Bright, P Lönn, PH Lin, PK Datta, PM Siegel, RJ Akhurst, RJ Akhurst, S DaCosta Byfield, S Dennler, S Edlund, S Strickson, SA Hawley, T Sonntag, TB Sundberg, Y Drabsch, Y Liu, Y Shi, Y Yang, Y Zhang, Y Zhang   +63 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation. [PDF]

PLoS Computational Biology, 2014
The TGF-β/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall system is unknown.
Junjie Wang, Lisa Tucker-Kellogg, Inn Chuan Ng, Ruirui Jia, P S Thiagarajan, Jacob K White, Hanry Yu   +6 more
doaj   +1 more source

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex

eLife, 2022
The hallmark event of the canonical transforming growth factor β (TGFβ) family signaling is the assembly of the Smad-complex, consisting of the common Smad, Smad4, and phosphorylated receptor-regulated Smads.
Meng Shi, Hieng Chiong Tie, Mahajan Divyanshu, Xiuping Sun, Yan Zhou, Boon Kim Boh, Leah A Vardy, Lei Lu   +7 more
doaj   +1 more source

A Folk Tale of Two Princesses [PDF]

, 2009
Bstan 'dzin tells a folk tale about two princesses and their evil servantThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad ...
Bkra shis bzang po
core  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. [PDF]

PLoS ONE, 2010
We have recently described that in an experimental model of atherosclerosis and in vascular smooth muscle cells (VSMCs) statins increased the activation of the Smad pathway by transforming growth factor-β (TGF-β), leading to an increase in TGF-β ...
Raúl Rodrigues Díez, Raquel Rodrigues-Díez, Carolina Lavoz, Sandra Rayego-Mateos, Esther Civantos, Juan Rodríguez-Vita, Sergio Mezzano, Alberto Ortiz, Jesús Egido, Marta Ruiz-Ortega, Marta Ruiz-Ortega   +10 more
doaj   +1 more source

Experiences of Hunting [PDF]

, 2009
O rgyan dban phyugs describes his personal hunting experiencesThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad Village and Ri
Bkra shis bzang po
core