Results 11 to 20 of about 25,530 (255)
Intracellular bacteria encode inhibitory SNARE-like proteins. [PDF]
PLoS ONE, 2009 Pathogens use diverse molecular machines to penetrate host cells and manipulate intracellular vesicular trafficking. Viruses employ glycoproteins, functionally and structurally similar to the SNARE proteins, to induce eukaryotic membrane fusion ...
Fabienne Paumet +7 more
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SNARE Proteins Are Required for Macroautophagy. [PDF]
Cell, 2011 Macroautophagy mediates the degradation of long-lived proteins and organelles via the de novo formation of double-membrane autophagosomes that sequester cytoplasm and deliver it to the vacuole/lysosome; however, relatively little is known about autophagosome biogenesis.
Nair U +15 more
europepmc +6 more sources
An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion. [PDF]
PLoS ONE, 2010 Biological membrane fusion is a basic cellular process catalyzed by SNARE proteins and additional auxiliary factors. Yet, the critical mechanistic details of SNARE-catalyzed membrane fusion are poorly understood, especially during rapid synaptic ...
Ting Guo, Lin-Chen Gong, Sen-Fang Sui
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SNARE proteins in membrane trafficking [PDF]
Traffic, 2017 SNAREsare the core machinery mediating membrane fusion. In this review, we provide an update on the recent progress onSNAREsregulating membrane fusion events, especially the more detailed fusion processes dissected by well‐developed biophysical methods and in vitro single molecule analysis approaches.
Tuanlao, Wang +2 more
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Epileptic Phenotypes Associated With SNAREs and Related Synaptic Vesicle Exocytosis Machinery
Frontiers in Neurology, 2022 SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptor) are an heterogeneous family of proteins that, together with their key regulators, are implicated in synaptic vesicle exocytosis and synaptic transmission. SNAREs represent the
Elisa Cali +3 more
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A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
Cell & Bioscience, 2023 Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD
Jin-Gu Lee +6 more
doaj +1 more source
SNARE-Ware: The Role of SNARE-Domain Proteins in Plant Biology [PDF]
Annual Review of Cell and Developmental Biology, 2007 In yeast and animal cells, members of the superfamily of N-ethylmaleimide-sensitive factor adaptor protein receptor (SNARE)-domain-containing proteins are key players in vesicle-associated membrane fusion events during transport processes between individual compartments of the endomembrane system, including exocytosis and endocytosis.
Lipka, V., Kwon, C., Panstruga, R.
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Cell Reports, 2013 Rapid endocytosis, which takes only a few seconds, is widely observed in secretory cells. Although it is more efficient in recycling vesicles than in slow clathrin-mediated endocytosis, its underlying mechanism, thought to be clathrin independent, is ...
Jianhua Xu +7 more
doaj +1 more source
SNARE proteins mediate lipid bilayer fusion [PDF]
Proceedings of the National Academy of Sciences, 1999 Lipid bilayers compartmentalize eukaryotic cells into distinct organelles. This compartmentalization allows for specialization of diverse cellular processes, from DNA polymerization to zymogen proteolysis. While the specific complement of proteins present in each organelle defines its function, there is a dynamic flux between these organelles.
J B, Bock, R H, Scheller
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The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions
eLife, 2021 SNARE proteins have been described as the effectors of fusion events in the secretory pathway more than two decades ago. The strong interactions between SNARE domains are clearly important in membrane fusion, but it is unclear whether they are involved ...
Jasmin Mertins +5 more
doaj +1 more source