Brain and Neuroscience Advances, 2018 In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed Na V 1.1–Na V 1.9.
John N. Wood, Federico Iseppon
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Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]
, 1992 The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
B Neumcke +15 more
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DDESC: Dragon database for exploration of sodium channels in human
BMC Genomics, 2008 Background Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as ...
Radovanovic Aleksandar +7 more
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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
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Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]
, 2013 Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai +44 more
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Studies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4. [PDF]
PLoS ONE, 2009 Much data, including crystallographic, support structural models of sodium and potassium channels consisting of S1-S4 transmembrane segments (the "voltage-sensing domain") clustered around a central pore-forming region (S5-S6 segments and the intervening
Zhongming Ma, Jun Kong, Roland G Kallen
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SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]
, 2016 The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An +2 more
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Structural Advances in Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pain ...
Daohua Jiang +5 more
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Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]
, 2013 We use Brownian dynamics (BD) simulations to study the ionic conduction and valence selectivity of a generic electrostatic model of a biological ion channel as functions of the fixed charge Qf at its selectivity filter.
Eisenberg, Robert S. +4 more
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A small fraction of strongly cooperative sodium channels boosts neuronal encoding of high frequencies. [PDF]
PLoS ONE, 2012 Generation of action potentials (APs) is a crucial step in neuronal information processing. Existing biophysical models for AP generation almost universally assume that individual voltage-gated sodium channels operate statistically independently, and ...
Min Huang, Maxim Volgushev, Fred Wolf
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