Results 31 to 40 of about 511,275 (351)
Amiloride-Sensitive Sodium Channels and Pulmonary Edema
Pulmonary Medicine, 2011 The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance.
Mike Althaus +2 more
doaj +1 more source
Frontiers in Physiology, 2015 Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH +1 more
doaj +1 more source
Cannabidiol interactions with voltage-gated sodium channels
eLife, 2020 Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait +5 more
doaj +1 more source
Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. [PDF]
PLoS Computational Biology, 2010 Sodium channels are one of the most intensively studied drug targets. Sodium channel inhibitors (e.g., local anesthetics, anticonvulsants, antiarrhythmics and analgesics) exert their effect by stabilizing an inactivated conformation of the channels ...
Robert Karoly +4 more
doaj +1 more source
Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart [PDF]
, 2015 With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes.
Close, Graeme L. +6 more
core +2 more sources
Sodium channels and pain [PDF]
Proceedings of the National Academy of Sciences, 1999 Although it is well established that hyperexcitability and/or increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability ...
S G, Waxman +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2023 During the second half of the last century, the prevalent knowledge recognized the voltage-gated sodium channels (VGSCs) as the proteins responsible for the generation and propagation of action potentials in excitable cells.
Ana Laura Sanchez-Sandoval +3 more
doaj +1 more source
Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. [PDF]
, 2017 In this issue of EMBO Molecular Medicine, Decher et al (2017) identify a point mutation in the K2P2 (TREK‐1) potassium (K+) channel that changes function in just those ways expected to predispose to right ventricular outflow tract (RVOT) ventricular
Goldstein, Steve An
core +2 more sources
Slow Dynamics in Ion-Conducting Sodium Silicate Melts: Simulation and Mode-Coupling Theory
, 2005 A combination of molecular-dynamics (MD) computer simulation and mode-coupling theory (MCT) is used to elucidate the structure-dynamics relation in sodium-silicate melts (NSx) of varying sodium concentration.
Angell C. A. +5 more
core +1 more source
New patents on topical anesthetics. [PDF]
, 2014 Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano +6 more
core +1 more source