Histological and Immunohistochemical Study on the Effect of Sodium iodate on the Retina of Adult Male Albino Rat and the Possible Protective Role of Silymarin [PDF]
The Egyptian Journal of Histology, 2021 Background: Retinal degenerative diseases are induced by many environmental and genetic agents and may lead to permanent blindness. Induced retinal degeneration by sodium iodate (NaIO3) is widely used to study mechanism of retinal cell death.
Rania Yassien +2 more
doaj +1 more source
5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. [PDF]
Oxid Med Cell Longev, 2022 Excessive reactive oxygen species (ROS) contribute to damage of retinal cells and the development of retinal diseases including age‐related macular degeneration (AMD).
Lee JJ +6 more
europepmc +2 more sources
Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss. [PDF]
GeroscienceAge-related macular degeneration (AMD) is a leading cause of blindness in elderly populations, yet the molecular events that initiate the early retinal defects that lead to visual function deficits remain poorly understood.
Subrahmanian SM +8 more
europepmc +2 more sources
Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model. [PDF]
Transl Vis Sci TechnolPurpose Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration with multifactorial etiology and no well-established treatment.
Naik P +4 more
europepmc +2 more sources
Antioxidants, 2023 Adenosine triphosphate (ATP) released from dying cells with high concentrations is sensed as a danger signal by the P2X7 receptor. Sodium iodate (NaIO3) is an oxidative toxic agent, and its retinal toxicity has been used as the model of dry age-related ...
Ponarulselvam Sekar +4 more
doaj +1 more source
RNA-seq analysis reveals differentially expressed inflammatory chemokines in a rat retinal degeneration model induced by sodium iodate. [PDF]
J Int Med Res, 2022 Objective Retinal degeneration (RD) is a group of serious blinding eye diseases characterized by photoreceptor cell apoptosis and progressive degeneration of retinal neurons. However, the underlying mechanism of its pathogenesis remains unclear.
Chen S +7 more
europepmc +2 more sources
Shiyan dongwu yu bijiao yixue, 2023 Objective To evaluate the effects of intraperitoneal injection of sodium iodate on the physiological indexes and retinal histopathological characteristics of SD rats comprehensively.
TAN Ying +5 more
doaj +1 more source
The Lyotropic Nature of Halates: An Experimental Study
Molecules, 2022 Unlike halides, where the kosmotropicity decreases from fluoride to iodide, the kosmotropic nature of halates apparently increases from chlorate to iodate, in spite of the lowering in the static ionic polarizability.
Mert Acar +5 more
doaj +1 more source
Inhibition of DUSP6 Activates Autophagy and Rescues the Retinal Pigment Epithelium in Sodium Iodate-Induced Retinal Degeneration Models In Vivo and In Vitro. [PDF]
Biomedicines, 2022 Autophagy plays a protective role in the retinal pigment epithelium (RPE) by eliminating damaged organelles in response to reactive oxygen species (ROS).
Tsai HY +13 more
europepmc +2 more sources
Frontiers in Cellular Neuroscience, 2022 Clearance phagocytosis is a documented function of Müller glia in the retina. However, the molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show that extracellular galectin-3 and protein S promote clearance phagocytosis
Deborah S. Lew +2 more
doaj +1 more source