Corrigendum: Transplanted Erythropoietin-Expressing Mesenchymal Stem Cells Promote Pro-survival Gene Expression and Protect Photoreceptors From Sodium Iodate-Induced Cytotoxicity in a Retinal Degeneration Model [PDF]
Frontiers in Cell and Developmental Biology, 2021 Avin Ee-Hwan Koh +18 more
doaj +2 more sources
Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats. [PDF]
Int J Mol Sci, 2023 Age-related macular degeneration (AMD) is a global health challenge. AMD causes visual impairment and blindness, particularly in older individuals. This multifaceted disease progresses through various stages, from asymptomatic dry to advanced wet AMD ...
Goo H +5 more
europepmc +2 more sources
Sodium Iodate-Induced Ferroptosis in Photoreceptor-Derived 661W Cells Through the Depletion of GSH. [PDF]
Int J Mol SciOxidative stress-induced photoreceptor cell death is closely associated with the etiology of age-related macular degeneration (AMD), and sodium iodate (SI) has been widely used as an oxidant stimulus in AMD models to induce retinal pigment epithelium ...
Chen C +8 more
europepmc +2 more sources
CAMK2D and Complement Factor I-Involved Calcium/Calmodulin Signaling Modulates Sodium Iodate-Induced Mouse Retinal Degeneration. [PDF]
Invest Ophthalmol Vis SciPurpose To investigate the effect of Ca2+/calmodulin-dependent protein kinase II (CAMKII) δ subtypes (CAMK2D) on sodium iodate (NaIO3)-induced retinal degeneration in mice.
Xu W, Cao L, Liu H.
europepmc +2 more sources
A PEDF-Derived Short Peptide Prevents Sodium Iodate-Induced Retinal Degeneration in Rats by Activating the SLC7A11/GSH/GPX4 Pathway in the RPE Cells. [PDF]
J Cell Mol MedRetinal pigment epithelial (RPE) cell damage caused by oxidative stress is a key factor in the pathogenesis of dry age‐related macular degeneration (AMD).
Ho TC, Tsai SH, Yeh SI, Sun MH, Tsao YP.
europepmc +2 more sources
Retinal BMI1 Expression Preserves Photoreceptors in Sodium-Iodate-Induced Oxidative Stress Models. [PDF]
Int J Mol SciDry age-related macular degeneration (AMD) is a leading cause of vision loss in individuals over 50, yet no approved therapies exist for early or intermediate stages of the disease. Oxidative stress is a central driver of retinal degeneration in AMD, and
Lu Z +5 more
europepmc +2 more sources
Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy. [PDF]
Transl Vis Sci TechnolPurpose Geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD), has limited treatment options. This study introduces a novel mouse model featuring an expanding GA patch that can be used to test mechanisms and therapeutics.
Anderson BD +5 more
europepmc +2 more sources
iPLA2β Protects Retinal Pigment Epithelium From Ferroptosis in a Sodium Iodate-Induced Model of Dry AMD. [PDF]
Invest Ophthalmol Vis SciPurpose Ferroptosis, characterized by lipid peroxidation, has been implicated in retinal pigment epithelium (RPE) degeneration in dry age-related macular degeneration (AMD). This study aimed to investigate the role of calcium-independent phospholipase A2
Suzuki T +9 more
europepmc +2 more sources
Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey. [PDF]
Invest Ophthalmol Vis SciPurpose Although sodium-iodate (SI)–induced retinal degeneration has been extensively studied in rodent models, its macular pathology and cone/rod vulnerability difference remains elusive.
Notomi S +8 more
europepmc +2 more sources
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE. [PDF]
Oxid Med Cell Longev, 2022 Senescent cells have been demonstrated to have lower cellular NAD+ levels and are involved in the development of various age‐related diseases, including age‐related macular degeneration (AMD).
Ren C +8 more
europepmc +2 more sources