Results 21 to 30 of about 567,501 (203)

Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model. [PDF]

Tissue Eng Regen Med, 2021
Background: Different methods have been used to inject stem cells into the eye for research. We previously explored the intravitreal route. Here, we investigate the efficacy of intravenous and subretinal-transplanted human dental pulp stem cells (DPSCs ...
Lam C, Alsaeedi HA, Koh AE, Harun MHN, Hwei ANM, Mok PL, Luu CD, Yong TK, Subbiah SK, Bastion MC.   +9 more
europepmc   +2 more sources

Histological and Immunohistochemical Study on the Effect of Sodium iodate on the Retina of Adult Male Albino Rat and the Possible Protective Role of Silymarin [PDF]

The Egyptian Journal of Histology, 2021
Background: Retinal degenerative diseases are induced by many environmental and genetic agents and may lead to permanent blindness. Induced retinal degeneration by sodium iodate (NaIO3) is widely used to study mechanism of retinal cell death.
Rania Yassien, Omyma Zedan, Nagwa Ghoneim   +2 more
doaj   +1 more source

P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types

Antioxidants, 2023
Adenosine triphosphate (ATP) released from dying cells with high concentrations is sensed as a danger signal by the P2X7 receptor. Sodium iodate (NaIO3) is an oxidative toxic agent, and its retinal toxicity has been used as the model of dry age-related ...
Ponarulselvam Sekar, George Hsiao, Yuan-Shen Chen, Wan-Wan Lin, Chi-Ming Chan   +4 more
doaj   +1 more source

Physiological Indexes and Histopathology Analysis of Sodium Iodate-Induced Retinitis Pigmentosa in Rats

Shiyan dongwu yu bijiao yixue, 2023
Objective To evaluate the effects of intraperitoneal injection of sodium iodate on the physiological indexes and retinal histopathological characteristics of SD rats comprehensively.
TAN Ying, LIAO Wenping, GAO Qilong, LI Yong, SHI Xinhui, WANG Jingkun   +5 more
doaj   +1 more source

The Lyotropic Nature of Halates: An Experimental Study

Molecules, 2022
Unlike halides, where the kosmotropicity decreases from fluoride to iodide, the kosmotropic nature of halates apparently increases from chlorate to iodate, in spite of the lowering in the static ionic polarizability.
Mert Acar, Duccio Tatini, Barry W. Ninham, Federico Rossi, Nadia Marchettini, Pierandrea Lo Nostro   +5 more
doaj   +1 more source

Testosterone promotes photoreceptor degeneration in the sodium iodate model. [PDF]

Exp Eye Res
Previously, we found that retinas of young male mice were more damaged than those of young female mice in the sodium iodate (NaIO3) model. The purpose of this study was to test whether reducing testosterone levels would be retina-protective. Male C57Bl/6J mice underwent surgical castration or sham surgery, then were given an intraperitoneal injection ...
Lee TT, Bell BA, Song Y, Dunaief JL.
europepmc   +3 more sources

Galectin-3 Promotes Müller Glia Clearance Phagocytosis via MERTK and Reduces Harmful Müller Glia Activation in Inherited and Induced Retinal Degeneration

Frontiers in Cellular Neuroscience, 2022
Clearance phagocytosis is a documented function of Müller glia in the retina. However, the molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show that extracellular galectin-3 and protein S promote clearance phagocytosis
Deborah S. Lew, Morgan J. McGrath, Silvia C. Finnemann   +2 more
doaj   +1 more source

Tamoxifen protects photoreceptors in the sodium iodate model. [PDF]

Exp Eye Res
Because the selective estrogen receptor modulator tamoxifen was shown to be retina-protective in the light damage and rd10 models of retinal degeneration, the purpose of this study was to test whether tamoxifen is retina-protective in a model where retinal pigment epithelium (RPE) toxicity appears to be the primary insult: the sodium iodate (NaIO3 ...
Lee TT, Bell BA, Anderson BD, Song Y, Dunaief JL.   +4 more
europepmc   +3 more sources

The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration

Redox Biology, 2020
Sorsby Fundus Dystrophy (SFD) is a rare inherited autosomal dominant macular degeneration caused by specific mutations in TIMP3. Patients with SFD present with pathophysiology similar to the more common Age-related Macular Degeneration (AMD) and loss of ...
Alyson Wolk, Mala Upadhyay, Mariya Ali, Jason Suh, Heidi Stoehr, Vera L. Bonilha, Bela Anand-Apte   +6 more
doaj   +1 more source

Self-Assembling Tacrolimus Nanomicelles for Retinal Drug Delivery

Pharmaceutics, 2020
Neovascular age-related macular degeneration (AMD) is characterized by an increase in reactive oxygen species (ROS) and pro-inflammatory cytokines in the retinal pigment epithelium cells.
Vrinda Gote, Abhirup Mandal, Meshal Alshamrani, Dhananjay Pal   +3 more
doaj   +1 more source