Sodium Iodate: Rapid and Clinically Relevant Model of AMD
Frontiers in Bioscience-LandmarkBackground: Age-related macular degeneration (AMD) is the most common cause of vision loss in people above the age of 50, affecting approximately 10% of the population worldwide and the incidence is rising.
Jasmine S. Geathers +8 more
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Tamoxifen protects photoreceptors in the sodium iodate model. [PDF]
Exp Eye ResBecause the selective estrogen receptor modulator tamoxifen was shown to be retina-protective in the light damage and rd10 models of retinal degeneration, the purpose of this study was to test whether tamoxifen is retina-protective in a model where retinal pigment epithelium (RPE) toxicity appears to be the primary insult: the sodium iodate (NaIO3 ...
Lee TT +4 more
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Complement C3 knockout protects photoreceptors in the sodium iodate model. [PDF]
Exp Eye ResComplement factor 3 (C3) has emerged as a primary therapeutic target in age-related macular degeneration (AMD) supported by genetic, histologic, and clinical trial evidence. Yet, the site(s) of action are unclear. The purpose of this study was to test the effect of C3 knockout on photoreceptors and retinal pigment epithelial cells (RPE) in the sodium ...
Wang T +6 more
europepmc +4 more sources
Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine Retina [PDF]
International Journal of Molecular Sciences, 2021 Age-related macular degeneration (AMD), one of the leading causes of blindness worldwide, causes personal suffering and high socioeconomic costs. While there has been progress in the treatments for the neovascular form of AMD, no therapy is yet available
Diana Pauly +2 more
exaly +3 more sources
Protective Effect of Quercetin on Sodium Iodate-Induced Retinal Apoptosis through the Reactive Oxygen Species-Mediated Mitochondrion-Dependent Pathway [PDF]
International Journal of Molecular Sciences, 2021 Age-related macular degeneration (AMD) leads to gradual central vision loss and is the third leading cause of irreversible blindness worldwide. The underlying mechanisms for this progressive neurodegenerative disease remain unclear and there is currently
Yuan-Yen Chang +2 more
exaly +3 more sources
Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG [PDF]
International Journal of Molecular Sciences, 2022 Purpose: The lack of suitable animal models for (dry) age-related macular degeneration (AMD) has hampered therapeutic research into the disease, so far.
Jacoline B Ten Brink +2 more
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Mitigation of Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells in vitro by Transgenic Erythropoietin-Expressing Mesenchymal Stem Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mesenchymal stem cells (MSC) have shown promise in restoring the vision of patients in clinical trials. However, this therapeutic effect is not observed in every treated patient and is possibly due to the inefficacies of cell delivery and high cell death
Avin Ee-Hwan Koh +9 more
doaj +2 more sources
Antioxidants, 2021 Oxidative damage of retinal pigment epithelium (RPE) cells plays an important role in the pathogenesis of blindness-related diseases, such as age-related macular degeneration (AMD).
Min-Yen Hsu +8 more
doaj +2 more sources
Carbohydrate Polymer Technologies and ApplicationsThe oxidative stress-induced degeneration of the retinal pigment epithelium (RPE) and secondary photoreceptor damage are the main causes of dry age-related macular degeneration (AMD). No effective interventions are currently available for use in clinical
Xu Yang +6 more
doaj +2 more sources
Corrigendum: Mitigation of Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells in vitro by Transgenic Erythropoietin-Expressing Mesenchymal Stem Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Avin Ee-Hwan Koh +9 more
doaj +2 more sources