Oxidative Model of Retinal Neurodegeneration Induced by Sodium Iodate: Morphofunctional Assessment of the Visual Pathway [PDF]
Antioxidants, 2023 Sodium iodate (NaIO3) has been shown to cause severe oxidative stress damage to retinal pigment epithelium cells. This results in the indirect death of photoreceptors, leading to a loss of visual capabilities.
Pedro De La Villa +2 more
exaly +5 more sources
(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration [PDF]
Frontiers in Medicine, 2022 Oxidative stress, mitochondrial impairment, and pathological amyloid beta (Aβ) deposition are involved in the pathogenesis of dry age-related macular degeneration (AMD).
Manjuan Peng +20 more
doaj +5 more sources
Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study [PDF]
Antioxidants, 2021 In this report, we evaluated the role of iron in sodium iodate (NaIO3)-induced model of age-related macular degeneration (AMD) in ARPE-19 cells in-vitro, and mouse models in-vivo.
Neena Singh +2 more
exaly +5 more sources
Evaluation of retinal structure changes with AI-based OCT image segmentation for sodium iodate induced retinal degeneration [PDF]
Frontiers in Cellular NeuroscienceSegmentations of retinal optical coherence tomography (OCT) images provide valuable information about each specific retinal layer. However, processing images from degenerative retina remains challenging.
Yong Zeng +7 more
doaj +3 more sources
Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells [PDF]
Cell Death and Disease, 2021 Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE) cells. However, the mechanism of RPE cell death induced by SI remains unclear. In this study, we investigated
Binghua Liu +11 more
doaj +3 more sources
Classification, location, and intensity of granules in retinal pigment epithelium following sodium iodate injection in rat animal model [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Age-related macular degeneration (AMD) is one of the eye diseases that can affect a person’s central vision. Retinal pigment epithelium (RPE) cells are damaged in this medical condition and some pigments are presented in these cells.
Mahboube Mousavi +5 more
doaj +3 more sources
Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration [PDF]
Scientific Reports, 2023 It is important to explore the effective approaches to prevent dry age-related macular degeneration (AMD). In this study, significantly decreased full-field electroretinograms wave amplitudes and disordered retina structures were detected in rat retinas ...
Yan Xing +10 more
doaj +3 more sources
Testosterone promotes photoreceptor degeneration in the sodium iodate model. [PDF]
Exp Eye ResPreviously, we found that retinas of young male mice were more damaged than those of young female mice in the sodium iodate (NaIO3) model. The purpose of this study was to test whether reducing testosterone levels would be retina-protective. Male C57Bl/6J mice underwent surgical castration or sham surgery, then were given an intraperitoneal injection ...
Lee TT, Bell BA, Song Y, Dunaief JL.
europepmc +4 more sources
Glabridin Attenuates the Retinal Degeneration Induced by Sodium Iodate In Vitro and In Vivo [PDF]
Frontiers in Pharmacology, 2020 BackgroundAge-related macular degeneration (AMD) is one of the major causes of blindness in the elderly over the age of 60. AMD is divided into dry AMD and wet AMD.
Jianhua Huang
exaly +4 more sources
Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium [PDF]
Antioxidants, 2021 Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO3), which is primarily toxic to the RPE, has often been used at a high
Xue Yang +3 more
doaj +3 more sources