(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration [PDF]
Frontiers in Medicine, 2022 Oxidative stress, mitochondrial impairment, and pathological amyloid beta (Aβ) deposition are involved in the pathogenesis of dry age-related macular degeneration (AMD).
Manjuan Peng +20 more
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Oxidative Model of Retinal Neurodegeneration Induced by Sodium Iodate: Morphofunctional Assessment of the Visual Pathway [PDF]
Antioxidants, 2023 Sodium iodate (NaIO3) has been shown to cause severe oxidative stress damage to retinal pigment epithelium cells. This results in the indirect death of photoreceptors, leading to a loss of visual capabilities.
Michael D. Espitia-Arias +4 more
doaj +4 more sources
Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration [PDF]
Scientific Reports, 2023 It is important to explore the effective approaches to prevent dry age-related macular degeneration (AMD). In this study, significantly decreased full-field electroretinograms wave amplitudes and disordered retina structures were detected in rat retinas ...
Yan Xing +10 more
doaj +3 more sources
Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells [PDF]
Cell Death and Disease, 2021 Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE) cells. However, the mechanism of RPE cell death induced by SI remains unclear. In this study, we investigated
Binghua Liu +11 more
doaj +2 more sources
Classification, location, and intensity of granules in retinal pigment epithelium following sodium iodate injection in rat animal model [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Age-related macular degeneration (AMD) is one of the eye diseases that can affect a person’s central vision. Retinal pigment epithelium (RPE) cells are damaged in this medical condition and some pigments are presented in these cells.
Mahboube Mousavi +5 more
doaj +2 more sources
Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study [PDF]
Antioxidants, 2021 In this report, we evaluated the role of iron in sodium iodate (NaIO3)-induced model of age-related macular degeneration (AMD) in ARPE-19 cells in-vitro, and mouse models in-vivo.
Ajay Ashok +7 more
doaj +2 more sources
Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium [PDF]
Antioxidants, 2021 Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO3), which is primarily toxic to the RPE, has often been used at a high
Xue Yang +3 more
doaj +2 more sources
Evaluation of retinal structure changes with AI-based OCT image segmentation for sodium iodate induced retinal degeneration [PDF]
Frontiers in Cellular NeuroscienceSegmentations of retinal optical coherence tomography (OCT) images provide valuable information about each specific retinal layer. However, processing images from degenerative retina remains challenging.
Yong Zeng +7 more
doaj +2 more sources
Glabridin Attenuates the Retinal Degeneration Induced by Sodium Iodate In Vitro and In Vivo [PDF]
Frontiers in Pharmacology, 2020 BackgroundAge-related macular degeneration (AMD) is one of the major causes of blindness in the elderly over the age of 60. AMD is divided into dry AMD and wet AMD.
Kaung Htet Aung +5 more
doaj +2 more sources
Mitigation of Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells in vitro by Transgenic Erythropoietin-Expressing Mesenchymal Stem Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mesenchymal stem cells (MSC) have shown promise in restoring the vision of patients in clinical trials. However, this therapeutic effect is not observed in every treated patient and is possibly due to the inefficacies of cell delivery and high cell death
Avin Ee-Hwan Koh +9 more
doaj +2 more sources