Results 41 to 50 of about 2,992 (185)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Narcolepsy and Cataplexy – a practical approach to diagnosis and managing the impact of this chronic condition on children and their families [PDF]

, 2017
Narcolepsy is a relatively common neurological condition affecting the regulation of normal sleep/wake cycles leading to excessive daytime sleepiness (EDS).
Blackwell, J, Elphick, H, Kingshott, R, Staniforth, T   +3 more
core   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

RESTORE: Once-nightly oxybate dosing preference and nocturnal experience with twice-nightly oxybates

Sleep Medicine: X
Objective/Background: Preference for extended-release, once-nightly sodium oxybate (ON-SXB, FT218) vs twice-nightly immediate-release (IR) oxybate was assessed in participants switching from IR oxybate to ON-SXB in an open-label/switch study, RESTORE ...
Asim Roy, Thomas Stern, John Harsh, J. Douglas Hudson, Akinyemi O. Ajayi, Bruce C. Corser, Emmanuel Mignot, Adrian Santamaria, Anne Marie Morse, Brian Abaluck, Sally Ibrahim, Paula K. Schweitzer, Katie Lancaster, Jordan Dubow, Jennifer Gudeman   +14 more
doaj   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Development of responder definitions for fibromyalgia clinical trials [PDF]

, 2012
Objective To develop responder definitions for fibromyalgia (FM) clinical trials using key symptom and function domains. Methods Twenty‐four candidate responder definitions were developed by expert consensus and were evaluated in 12 randomized ...
Ang, Arnold, Arnold, Arnold, Arnold, Arnold, Arnold, Belza, Bennett, Bennett, Boers, Carette, Carville, Cella, Choy, Dunkl, Dworkin, Farrar, Felson, Geisser, Hays, Hudson, Mease, Mease, Mease, Mease, Mease, Mease, O'Malley, Russell, Seidenberg, Simms, Simms, Smets, Ware, Williams, Witter, Wolfe, Wolfe   +38 more
core   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Restorative sleep predicts the resolution of chronic widespread pain: results from the EPIFUND study [PDF]

, 2016
PublishedJournal ArticleMulticenter StudyResearch Support, Non-U.S. Gov'tVersion of record of article published in Rheumatology (Oxford). 2008 Dec; 47(12): 1809–1813. Published online 2008 Oct 7. doi: 10.1093/rheumatology/ken389OBJECTIVES: Poor sleep is
Davies, KA, Dickens, Chris, Macfarlane, GJ, McBeth, J, Morriss, R, Nicholl, BI, Ray, D   +6 more
core   +1 more source

European guideline and expert statements on the management of narcolepsy in adults and children [PDF]

, 2021
Background and purpose: Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence-based guidelines for the management of narcolepsy in both adults and ...
Baldin, Elisa, Bassetti, Claudio L. A., Dauvilliers, Yves, Dolenc-Groselj, Leja, Jennum, Poul, Kallweit, Ulf, Khatami, Ramin, Lammers, Gert J., Lecendreux, Michel, Manconi, Mauro, Mayer, Geert, Partinen, Markku, Plazzi, Giuseppe, Pollmaecher, Thomas, Reading, Paul, Santamaria, Joan, Sonka, Karel, Vignatelli, Luca   +17 more
core   +11 more sources

Once‐Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy

Journal of Sleep Research, EarlyView.
ABSTRACT Data from the REST‐ON trial were not available before the 2021 American Academy of Sleep Medicine (AASM) clinical practice guideline update, which included a literature review through August 2020. This post hoc analysis from REST‐ON assessed participants who achieved clinically significant improvements on individual AASM clinical significance ...
Luis E. Ortiz, Anne Marie Morse, Michael J. Thorpy, Clete A. Kushida, John Harsh, Thomas Roth, Jennifer Gudeman, Yves Dauvilliers   +7 more
wiley   +1 more source