GHB’s Path to Legitimacy: An Administrative and Legislative History of Xyrem [PDF]
, 2012 This paper traces the path of a chemical compound (gamma-hydroxybutyrate, or GHB) from its status as an abused street drug to that of a legitimate, life-altering prescription treatment for a debilitating condition.
Neuman, Ariel
core
Narcolepsy 2025 (with an Australasian perspective)
Internal Medicine Journal, Volume 55, Issue 11, Page 1805-1813, November 2025.Abstract Narcolepsy is a disorder of central hypersomnolence, which, while uncommon, can carry profound implications for affected individuals. Despite this, it remains under‐recognised within the medical community and presents frequent diagnostic and treatment challenges in the Australasian setting.
Amelia Lin +3 more
wiley +1 more source
Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues [PDF]
, 2018 γ-Hydroxybutyric acid (GHB) is an endogenous short-chain fatty acid popular as a recreational drug due to sedative and euphoric effects, but also often implicated in drug-facilitated sexual assaults owing to disinhibition and amnesic properties.
Marclay, François +4 more
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Treatment of Essential Tremor: Are there Issues We are Overlooking? [PDF]
, 2012 Background: Essential tremor (ET) is one of the most common neurological diseases. Although a large number of medications have been tested, there are only two first-line medications, primidone and propranolol, which is a situation that has not changed in
Elan D. Louis
core +1 more source
Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon
Journal of Internal Medicine, Volume 298, Issue 5, Page 392-423, November 2025.Abstract Alcohol and other substance use disorders (ASUDs) are prevalent and major contributors to global morbidity and mortality. Their impact extends beyond the individual, imposing significant burdens on families, communities, healthcare systems, and society at large.
Anna Loften +3 more
wiley +1 more source
No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy [PDF]
, 2018 We report on four patients with narcolepsy with cataplexy (NC), who were treated with high-dose intravenous immunoglobulins (IVIg). Although in some patients transient effects were seen of both objective (multiple sleep latency test and maintenance of ...
Bassetti, C. +3 more
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Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management [PDF]
, 2012 Fibromyalgia Syndrome (FMS) is a chronic condition causing pain, stiffness, and tenderness of the muscles, tendons, and joints. It is also characterized by restless sleep, tiredness, fatigue, anxiety, depression, and disturbances in bowel functions.
Jahan, Firdous +3 more
core +2 more sources
Brain and Behavior, Volume 15, Issue 10, October 2025.Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf +9 more
wiley +1 more source
Alcohol-responsive Action Myoclonus of the Leg in Prostate Cancer: A Novel Paraneoplastic Syndrome?
Tremor and Other Hyperkinetic Movements, 2015 Background: Paraneoplastic movement disorders in prostate cancer are rare, and to our knowledge paraneoplastic myoclonus has not previously been reported.
Pichet Termsarasab, Steven J. Frucht
doaj +1 more source
The Space–Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Research suggests that the spatial profile of slow wave activity (SWA) could be altered in hypersomnolence. Slow oscillations (SOs; 0.5–1.5 Hz), single waveform events contributing to SWA, can be labelled as Global, Frontal, or Local depending on their presentation on the scalp.
Mahmoud Alipour +5 more
wiley +1 more source