Results 251 to 260 of about 120,164 (279)

Solid‐Phase Synthesis of DOTA–Peptides

Chemistry – A European Journal, 2004
AbstractA general synthetic route to two DOTA‐linked N‐Fmoc amino acids (DOTA‐F and DOTA‐K) is described that allows insertion of DOTA at any endo‐position within a peptide sequence. Three model pentapeptides were prepared to test the general utility of these derivatives in solid‐phase peptide synthesis.
Luis M, De León-Rodriguez, Zoltan, Kovacs, Gregg R, Dieckmann, A Dean, Sherry   +3 more
openaire   +2 more sources

Solid-Phase Synthesis of Lipidated Peptides

Journal of the American Chemical Society, 2002
Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after ...
Ludolph, B., Eisele, F., Waldmann, H.
openaire   +3 more sources

Apparatus for Solid-Phase Peptide Synthesis

Science, 1967
The apparatus, designed for solid-phase peptide synthesis, consists of a round-bottom flask, rocked on a wrist-shaker, and fitted with a special dropping funnel and a fritted filter disc embedded within the flask. The dropping funnel is designed to wash down the polymer adhering to the neck of the flask.
M C, Khosla, R R, Smeby, F M, Bumpus
openaire   +2 more sources

Analytical Methods for Solid Phase Peptide Synthesis

Current Organic Chemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
SABATINO, GIUSEPPINA, M. Chelli, BRANDI, ALBERTO, PAPINI, ANNA MARIA   +3 more
openaire   +4 more sources

Solid phase peptide synthesis

1991
This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
openaire   +1 more source

Convergent solid‐phase peptide synthesis

International Journal of Peptide and Protein Research, 1991
The solid‐phase synthesis, photolytic detachment from the solid support and purification in solution, of a fully‐protected octapeptide containing a methionine residue (protected as the sulphoxide) is described. Protection of methionine in this manner avoids problems associated with the oxidation of this residue during the photolysis.
PAUL LLOYD‐WILLIAMS, FERNANDO ALBERICIO, ERNEST GIRALT   +2 more
openaire   +1 more source

Solid-phase peptide synthesis

1994
Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
openaire   +1 more source

Active esters in solid-phase peptide synthesis

Journal of Protein Chemistry, 1989
Incorporation of single amino acid residues into peptide chains built on insoluble polymeric supports a priori appeared promising: the use of isolated, well defined (and potentially commercially available) reactive intermediates were expected to reduce the extent of undesired side reactions.
M, Bodanszky, M A, Bednarek
openaire   +2 more sources

Solid Phase Peptide Synthesis

1988
By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
openaire   +1 more source

Solid-Phase Peptide Synthesis

Endeavour, 1965
EBERHARD SCHRÖDER, KLAUS LÜBKE
openaire   +4 more sources