Results 11 to 20 of about 1,029,734 (328)
Grafted supports in solid-phase synthesis [PDF]
Biopolymers, 2000 Solid-phase synthesis is greatly dependent on the solid phase. We are interested in the development of a "pellicular" type of solid support where a more mobile polymer is grafted to rigid plastics. Compared to low cross-linked microporous beads that dominate the field, this approach allows great flexibility of design, as plastics are available as ...
Firas Rasoul +8 more
openalex +4 more sources
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis
Nature Chemistry, 2021 Recent advances in end-to-end continuous-flow synthesis are rapidly expanding the capabilities of automated customized syntheses of small-molecule pharmacophores, resulting in considerable industrial and societal impacts; however, many hurdles persist ...
Chenguang Liu +9 more
semanticscholar +1 more source
Synlett, 1998 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Harry C. J. Ottenheijm +3 more
openaire +2 more sources
Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
Goran Kragol +5 more
openaire +8 more sources
Molecules, 2015 Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A secondary α-1,2,3-triazoloamide library was constructed and expanded by a previously developed solid-phase synthetic route and a ...
Doohyun Lee +13 more
doaj +1 more source
Greening Fmoc/tBu solid-phase peptide synthesis
, 2020 Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase synthesis is the method of choice for the synthesis of these molecules in both research and industrial settings.
Othman Al Musaimi +2 more
semanticscholar +1 more source
Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai +3 more
doaj +1 more source
First total synthesis of hoshinoamide A
Beilstein Journal of Organic Chemistry, 2021 Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou +5 more
doaj +1 more source
ChemEngineering, 2020 Coal gasification is a new direction for the clean utilization of coal, but it also brings huge environmental pressure on solid waste. In this paper, the high-crystallinity single-phase zeolite A was prepared by solid-phase alkali fusion synthesis from ...
Wenxin Ji +10 more
doaj +1 more source
Solid Phase versus Solution Phase Synthesis of Heterocyclic Macrocycles
Molecules, 2013 Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior.
Shelli R. McAlpine, Seong Jong Kim
doaj +1 more source