Combination of automated solid-phase and enzymatic oligosaccharide synthesis provides access to α(2,3)-sialylated glycans. [PDF]
Chemical Communications, 2015 A synthetic strategy combining automated solid-phase chemical synthesis and enzymatic sialylation was developed to access α(2,3)-sialylated glycans.
Richard J. Fair +2 more
semanticscholar +3 more sources
Greener solvents for solid-phase synthesis [PDF]
, 2017 The use of a variety of green solvents to swell a diverse range of resins used in solid-phase synthesis is investigated. Good swelling is shown to depend on the structure of the resin and the solvent.
S. Lawrenson +3 more
semanticscholar +3 more sources
The interplay between thermodynamics and kinetics in the solid-state synthesis of layered oxides. [PDF]
, 2020 In the synthesis of inorganic materials, reactions often yield non-equilibrium kinetic byproducts instead of the thermodynamic equilibrium phase. Understanding the competition between thermodynamics and kinetics is a fundamental step towards the rational
Bai, Jianming +14 more
core +1 more source
Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity [PDF]
, 2015 YesThe duocarmycins are potent antitumour agents with potential in the development of antibody drug conjugates (ADCs) as well as being clinical candidates in their own right.
Michael J. Stephenson +9 more
openalex +5 more sources
Greening Fmoc/tBu solid-phase peptide synthesis
, 2020 Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase synthesis is the method of choice for the synthesis of these molecules in both research and industrial settings.
Othman Al Musaimi +2 more
semanticscholar +1 more source
Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines [PDF]
, 2011 A versatile solid-phase approach to sequence-defined polyamidoamines was developed. Four different Fmoc-polyamino acid building blocks were synthesized by selective protection of symmetrical oligoethylenimine precursors followed by introduction of a ...
Badgujar, Naresh +2 more
core +1 more source
Temperature Dependent Piezoelectric Properties of Lead-Free (1-x)K0.6Na0.4NbO3–xBiFeO3 Ceramics [PDF]
, 2020 (1-x)K0.4Na0.6NbO3–xBiFeO3 lead-free piezoelectric ceramics were successfully prepared in a single perovskite phase using the conventional solid-state synthesis.
Feteira, Antonio +6 more
core +3 more sources
Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai +3 more
doaj +1 more source
First total synthesis of hoshinoamide A
Beilstein Journal of Organic Chemistry, 2021 Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou +5 more
doaj +1 more source
Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor [PDF]
, 2019 On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time.
Guthrie, Duncan +3 more
core +2 more sources