Results 11 to 20 of about 1,773,765 (367)
Photolabile Linkers for Solid-Phase Synthesis. [PDF]
ACS Combinatorial Science, 2018 Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild reaction ...
R. J. T. Mikkelsen +4 more
semanticscholar +7 more sources
Parallel solid-phase synthesis of diaryltriazoles [PDF]
Beilstein Journal of Organic Chemistry, 2012 A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a ...
Matthias Wrobel +2 more
doaj +5 more sources
Solid-Phase Synthesis of s-Tetrazines. [PDF]
Org Lett, 2023 An efficient synthesis of s-tetrazines by solid-phase methods is described. This synthesis route was compatible with different solid-phase resins and linkers and did not require metal catalysts or high temperatures. Monosubstituted tetrazines were routinely synthesized using thiol-promoted chemistry, using dichloromethane as a carbon source, while ...
Alghamdi ZS +4 more
europepmc +5 more sources
Solid-Phase Synthesis of Megamolecules. [PDF]
J Am Chem Soc, 2020 This paper presents a solid-phase strategy to efficiently assemble multiprotein scaffolds-known as megamolecules-without the need for protecting groups and with precisely defined nanoscale architectures. The megamolecules are assembled through sequential reactions of linkers that present irreversible inhibitors for enzymes and fusion proteins ...
Kimmel BR +4 more
europepmc +5 more sources
Synlett, 1998 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Harry C. J. Ottenheijm +3 more
openaire +2 more sources
Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
Goran Kragol +5 more
openaire +8 more sources
First total synthesis of hoshinoamide A
Beilstein Journal of Organic Chemistry, 2021 Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou +5 more
doaj +1 more source
Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor [PDF]
, 2019 On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time.
Guthrie, Duncan +3 more
core +2 more sources
Greening Fmoc/tBu solid-phase peptide synthesis
, 2020 Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase synthesis is the method of choice for the synthesis of these molecules in both research and industrial settings.
Othman Al Musaimi +2 more
semanticscholar +1 more source
Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines [PDF]
, 2011 A versatile solid-phase approach to sequence-defined polyamidoamines was developed. Four different Fmoc-polyamino acid building blocks were synthesized by selective protection of symmetrical oligoethylenimine precursors followed by introduction of a ...
Badgujar, Naresh +2 more
core +1 more source