Results 11 to 20 of about 788,804 (281)
Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity [PDF]
, 2015 YesThe duocarmycins are potent antitumour agents with potential in the development of antibody drug conjugates (ADCs) as well as being clinical candidates in their own right.
Adcock, C. +9 more
core +4 more sources
Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
doaj +1 more source
Solid-Phase Synthesis of s-Tetrazines [PDF]
Organic Letters, 2023 An efficient synthesis of s-tetrazines by solid-phase methods is described. This synthesis route was compatible with different solid-phase resins and linkers and did not require metal catalysts or high temperatures. Monosubstituted tetrazines were routinely synthesized using thiol-promoted chemistry, using dichloromethane as a carbon source, while ...
Zainab S. Alghamdi +4 more
openaire +3 more sources
The interplay between thermodynamics and kinetics in the solid-state synthesis of layered oxides. [PDF]
, 2020 In the synthesis of inorganic materials, reactions often yield non-equilibrium kinetic byproducts instead of the thermodynamic equilibrium phase. Understanding the competition between thermodynamics and kinetics is a fundamental step towards the rational
Bai, Jianming +14 more
core +1 more source
Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
Lumbierres, M. +5 more
openaire +6 more sources
Molecules, 2015 Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A secondary α-1,2,3-triazoloamide library was constructed and expanded by a previously developed solid-phase synthetic route and a ...
Doohyun Lee +13 more
doaj +1 more source
Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines [PDF]
, 2011 A versatile solid-phase approach to sequence-defined polyamidoamines was developed. Four different Fmoc-polyamino acid building blocks were synthesized by selective protection of symmetrical oligoethylenimine precursors followed by introduction of a ...
Badgujar, Naresh +2 more
core +1 more source
Temperature Dependent Piezoelectric Properties of Lead-Free (1-x)K0.6Na0.4NbO3–xBiFeO3 Ceramics [PDF]
, 2020 (1-x)K0.4Na0.6NbO3–xBiFeO3 lead-free piezoelectric ceramics were successfully prepared in a single perovskite phase using the conventional solid-state synthesis.
Feteira, Antonio +6 more
core +3 more sources
Solid-Phase Synthesis of Megamolecules
Journal of the American Chemical Society, 2020 This paper presents a solid-phase strategy to efficiently assemble multiprotein scaffolds-known as megamolecules-without the need for protecting groups and with precisely defined nanoscale architectures. The megamolecules are assembled through sequential reactions of linkers that present irreversible inhibitors for enzymes and fusion proteins ...
Blaise R. Kimmel +4 more
openaire +3 more sources
Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai +3 more
doaj +1 more source