Results 31 to 40 of about 780,981 (298)

Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative

Discover Oncology
To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was designed to encapsulate and localize the intestinal release of the loaded genistein-ginseng (GST-GNS) solid ...
Samaa Abdullah, Shadab Md, Abeer A. Altamimi, Hadil Alahdal, Raisuddin Ali, Huda Mohammed Alkreathy, Shahid Karim   +6 more
doaj   +1 more source

Formulation, Characterization, and in Vivo Evaluation of Celecoxib-PVP Solid Dispersion Nanoparticles Using Supercritical Antisolvent Process

Molecules, 2014
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process.
Eun-Sol Ha, Gwang-Ho Choo, In-Hwan Baek, Min-Soo Kim   +3 more
doaj   +1 more source

Exciton dispersion in molecular solids

Journal of Physics: Condensed Matter, 2015
The investigation of the exciton dispersion (i.e. the exciton energy dependence as a function of the momentum carried by the electron-hole pair) is a powerful approach to identify the exciton character, ranging from the strongly localised Frenkel to the delocalised Wannier-Mott limiting cases.
Cudazzo P., Sottile F., Rubio A., Gatti M.   +3 more
openaire   +5 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Optimizing the Formulation for Ginkgolide B Solid Dispersion

Open Life Sciences, 2018
The main purpose of our study is to optimize the formulation for Ginkgolide B (GB) solid dispersion in order to improve its dissolution in water. For the preparation of GB solid dispersion, we use a solvent method.
Wu Xiao, Huo Qing, Quan Qizhe, Yang Xiaofang, Yu Na, Wang Yue   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Atorvastatin solid dispersion for bioavailability enhancement

Journal of Advanced Pharmaceutical Technology & Research, 2016
Atorvastatin calcium is a lipid-lowering agent. It has approximately 15% of bioavailability, remaining amount of drug showed adverse effect which is undesirable for patients.
Shamsuddin, Mohammad Fazil, Shahid H Ansari, Javed Ali   +3 more
doaj   +1 more source

Acoustic Characteristics Analysis of Double-Layer Liquid-Filled Pipes Based on Acoustic–Solid Coupling Theory

Applied Sciences, 2023
Based on the theory of acoustic–solid coupling, the phase velocity-thickness product of a double-layer liquid-filled pipeline is analyzed, and the dispersion relationship between angular frequency and wavenumber–thickness product is analyzed, providing a
Jin Yan, Jiangfeng Li, Lvlong Zou, Dapeng Zhang, Cheng Wang, Zhi Tang   +5 more
doaj   +1 more source

Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique [PDF]

, 2011
Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by ...
Ali Nokhodchi, Hadi Valizadeh, Leila Mohammadi, Mohammad Barzegar-Jalali, Parvin Zakeri-Milani, Somayeh Hallaj Nezhadi   +5 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source