Results 51 to 60 of about 128,995 (308)

Characterization of olanzapine-solid dispersions.

Iranian journal of pharmaceutical research : IJPR, 2011
To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization.
Krishnamoorthy, Venkateskumar, Nagalingam, Arunkumar, Ranjan Prasad, Verma Priya, Parameshwaran, Siva, George, Neema, Kaliyan, Punitha   +5 more
openaire   +2 more sources

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]

, 2019
Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair, Alhayali, Allam, Alonzo, Boateng, Brady, Brouwers, Campisi, Chapple, Curatolo, De Caro, El-Setouhy, ElMeshad, Gao, Garsuch, Gittings, Guo, Hanif, Hobbs, Huang, Humphrey, Jug, Kalia, Kapoor, Kim, Koland, Korhonen, Li, Liew, Madhav, Mashru, Matsubara, Miller-Chou, Montorsi, Nagy, Patel, Prabhu, Prasad, Preis, Preis, Preis, Radebaugh, Repka, Rossi, Runja, Sharma, Singh, Singh, Singh, Singh, Slavkova, Tanno, Vila, Visser, Vuddanda, Vuddanda, Yang, Zhang   +57 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The Influence of the Polymer Type on the Quality of Newly Developed Oral Immediate-Release Tablets Containing Amiodarone Solid Dispersions Obtained by Hot-Melt Extrusion

Molecules, 2022
The present study aims to demonstrate the influence of the polymer-carrier type and proportion on the quality performance of newly developed oral immediate-release tablets containing amiodarone solid dispersions obtained by hot-melt extrusion.
Ancuța Cătălina Fița, Ana Andreea Secăreanu, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Irina Atkinson, Adriana Rusu, Erand Mati, Valentina Anuta, Anca Lucia Pop   +9 more
doaj   +1 more source

Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]

, 2019
The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B., Dave, Vivek S, Patil, Arun T., Pethe, Anil M., Raut, Nishikant, Telange, Darshan R., Umekar, Milind J.   +6 more
core   +1 more source

Direct Numerical Simulations of Electrophoresis of Charged Colloids [PDF]

, 2006
We propose a numerical method to simulate electrohydrodynamic phenomena in charged colloidal dispersions. This method enables us to compute the time evolutions of colloidal particles, ions, and host fluids simultaneously by solving Newton, advection ...
D. C. Henry, E. Hückel, J.-L. Barrat, Kang Kim, M. Smoluchowski, Ryoichi Yamamoto, T. Yamaue, W. B. Russel, Yasuya Nakayama   +8 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
doaj   +1 more source

Matrix Solid Phase Dispersion

, 2012
Matrix solid-phase dispersion (MSPD) is a simple, fast, and versatile technique for preparation of solid, semi-solid, liquid, and viscous samples. Since its introduction two decades ago, MSPD has experienced rapid development and, nowadays, can be considered a widely accepted technique in many research areas.
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source