Results 11 to 20 of about 263,841 (302)

Automated solid-phase peptide synthesis to obtain therapeutic peptides [PDF]

Beilstein Journal of Organic Chemistry, 2014
The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.
Veronika Mäde, Sylvia Els-Heindl, Annette G. Beck-Sickinger   +2 more
doaj   +4 more sources

Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. [PDF]

, 2012
In the forthcoming era of cancer gene therapy, efforts will be devoted to the development of new efficient and non-toxic gene delivery vectors. In this regard, the use of Fmoc/Boc-protected oligo(ethane amino)acids as building blocks for solid-phase ...
Akinc, Aumailley, Behr, Blessing, Boussif, Breunig, Carlos Mas-Moruno, Chollet, Christian Dohmen, Christina Troiber, Cotten, Cox, David Schaffert, Davis, Davis, Dechantsreiter, Desgrosellier, Drake, Edinger, Ellman, Erbacher, Ernest Giralt, Ernst Wagner, Felding-Habermann, Felgner, Fella, Grandinetti, Harbottle, Hartmann, Hartmann, Haubner, Horst Kessler, Irene Martin, J., Kantlehner, Kichler, Kim, Kursa, Li, Lin, Luthman, Madder, Mas-Moruno, McKenzie, Meritxell Teixidó, Merkel, Meyer, Meyer, Michael Günther, Moghimi, Mosca, Nie, Oba, Oupicky, Pack, Petra Kos, Pfaff, Plank, Reis, Ruoslahti, Russ, Russ, Schaffert, Schaffert, Schaffert, Schiffelers, Sonawane, Trubetskoy, Ulrich Lächelt, Varkouhi, Wagner, Wagner, Wagner, Wagner, Walker, Wu, Xia, Xu, Zintchenko   +78 more
core   +4 more sources

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

Materials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo, P. Wang, Q. Zheng, R. Han, C. Shi, L. Wang, Y. Hong, Y. Liu, Y. Sha   +8 more
doaj   +1 more source

Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

Green Chemistry Letters and Reviews, 2021
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +1 more source

First total synthesis of hoshinoamide A

Beilstein Journal of Organic Chemistry, 2021
Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao, Long Liu   +5 more
doaj   +1 more source

Fragment synthesis of disulfide-containing peptides

MethodsX, 2020
A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai, Na Yue, Wenlong Huang, Hai Qian   +3 more
doaj   +1 more source

5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides

Molecules, 2022
The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is ...
Urszula Bąchor, Agnieszka Lizak, Remigiusz Bąchor, Marcin Mączyński   +3 more
doaj   +1 more source

Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor [PDF]

, 2019
On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time.
Guthrie, Duncan, Nuño, Manuel, Seeberger, Peter H., Sletten, Eric T.   +3 more
core   +2 more sources

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2018
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S., Barner-Kowollik, Christopher, Becer, C. Remzi, Collis, Dominic, Edwards-Gayle, Charlotte J. C., Hamley, Ian W., Hartweg, Manuel, Kaupp, Michael, Radvar, Elham, Rambo, Robert, Reza, Mehedi, Ruokolainen, Janne, Steinkoenig, Jan   +12 more
core   +1 more source

HOBt·DCHA-Mediated Synthesis of Sterically Hindered Peptides employing Fmoc-Amino Acid Chlorides in Both Solution-Phase and Solid Phase Methods [PDF]

, 2008
The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization.
Krishna, G.C., Sudarshan, N.S., Sureshbabu, V.V.   +2 more
core   +1 more source