Results 21 to 30 of about 327,171 (380)

New green base for Fmoc removal in solid-phase peptide synthesis: 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), a promising sustainable alternative to piperidine

Green Chemistry Letters and Reviews
Developing greener synthetic methodologies requires replacing hazardous reagents with more sustainable alternatives. In solid-phase peptide synthesis (SPPS), piperidine is the standard base for Fmoc group removal, but its toxicity, environmental concerns,
Maria Carmina Scala, Giovanni Vivenzio, Michele Manfra, Marina Sala, Pietro Campiglia   +4 more
doaj   +2 more sources

Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins [PDF]

Molecules, 2018
An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene ...
Yahson F. Varela, Magnolia Vanegas Murcia, Manuel Elkin Patarroyo   +2 more
doaj   +2 more sources

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

Materials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo, P. Wang, Q. Zheng, R. Han, C. Shi, L. Wang, Y. Hong, Y. Liu, Y. Sha   +8 more
doaj   +1 more source

First total synthesis of hoshinoamide A

Beilstein Journal of Organic Chemistry, 2021
Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao, Long Liu   +5 more
doaj   +1 more source

Synthesis of the transmembrane domain of the accessory protein ORF7a of SARS‐CoV‐2 using solid phase peptide synthesis and analyzing the oligomerization state

FASEB J, 2022
Hobart T, Reichart T.
europepmc   +3 more sources

Harnessing polarity and viscosity to identify green binary solvent mixtures as viable alternatives to DMF in solid-phase peptide synthesis

, 2021
Solid-phase peptide synthesis (SPPS) enables routine synthesis of virtually any type of peptide sequence and is the preferred method for peptide synthesis in academia and the pharmaceutical industry alike.
Vincent Martin, S. Jadhav, P. H. G. Egelund, Raphael Liffert, Henrik Johansson Castro, Tobias Krüger, K. Haselmann, Sebastian Thordal Le Quement, F. Albericio, Frank Dettner, Carolin Lechner, Ralph Schönleber, D. Pedersen   +12 more
semanticscholar   +1 more source

Fragment synthesis of disulfide-containing peptides

MethodsX, 2020
A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai, Na Yue, Wenlong Huang, Hai Qian   +3 more
doaj   +1 more source

5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides

Molecules, 2022
The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is ...
Urszula Bąchor, Agnieszka Lizak, Remigiusz Bąchor, Marcin Mączyński   +3 more
doaj   +1 more source

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2018
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S., Barner-Kowollik, Christopher, Becer, C. Remzi, Collis, Dominic, Edwards-Gayle, Charlotte J. C., Hamley, Ian W., Hartweg, Manuel, Kaupp, Michael, Radvar, Elham, Rambo, Robert, Reza, Mehedi, Ruokolainen, Janne, Steinkoenig, Jan   +12 more
core   +1 more source

Greening Fmoc/tBu solid-phase peptide synthesis

, 2020
Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase synthesis is the method of choice for the synthesis of these molecules in both research and industrial settings.
Othman Al Musaimi, B. G. de la Torre, F. Albericio   +2 more
semanticscholar   +1 more source