Results 31 to 40 of about 263,841 (302)

Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles

Applied Sciences, 2013
We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis.
Yoshinobu Fukumori, Hideki Ichikawa, Yoshimi Nozawa, Natsuki Shinozaki, Keiko Hojo   +4 more
doaj   +1 more source

Chemistry of Peptide-Oligonucleotide Conjugates: A Review

Molecules, 2021
Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova, Alesya Fokina, Dmitry Stetsenko   +2 more
doaj   +1 more source

Solid-Phase Synthesis of the Lipopeptide Myr-HBVpreS/2-78, a Hepatitis B Virus Entry Inhibitor

Molecules, 2010
Chronic HBV infection is the leading cause of liver cirrhosis and hepatocellular carcinoma (HCC). Synthetic peptides derived from the N-terminus of the large HBV envelope protein (L-protein) have been shown to efficiently block HBV entry.
Walter Mier, Stephan Urban, Andreas Schulze, Uwe Haberkorn, Thomas Müller, Alexa Schieck   +5 more
doaj   +1 more source

Heat-enhanced peptide synthesis on Teflon-patterned paper [PDF]

, 2016
In this report, we describe the methodology for 96 parallel organic syntheses of peptides on Teflon-patterned paper assisted by heating with an infra-red lamp.
Deiss, Frédérique, Derda, Ratmir, Matochko, Wadim L., Yang, Yang   +3 more
core   +1 more source

Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

Nature Communications, 2020
Aspartimide formation is a frequently occurring problem during peptide synthesis. Here, the authors present cyanosulfurylides as a protection group that masks aspartic acid residues during solid phase peptide synthesis, thus preventing aspartimide ...
Kevin Neumann, Jakob Farnung, Simon Baldauf, Jeffrey W. Bode   +3 more
doaj   +1 more source

DNA display III. Solid-phase organic synthesis on unprotected DNA. [PDF]

PLoS Biology, 2004
DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate utility, however, hinges upon the diversity of chemical reactions that can be executed in the presence of unprotected DNA.
David R Halpin, Juanghae A Lee, S Jarrett Wrenn, Pehr B Harbury   +3 more
doaj   +1 more source

Silicon tetrachloride and phenol as N(α)-t-butoxycarbonyl group deprotecting agent in solid phase peptide synthesis [PDF]

, 1996
The combination of 1M silicon tetrachloride and 3M phenol serves as an efficient N(α)-t-butoxycarbonyl deblocking agent in solid phase peptide synthesis, the duration of the cleavage being 10 min.
Gangadhar, B.P., Sivanandaiah, K.M., Sureshbabu, V.V.   +2 more
core   +1 more source

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
Alejandro González-Cantó, Algueró B., Anna Massaguer, Barragán F., Barragán F., Bauer W., Carlos González, Cascini G. L., Casini A., Chaplin A. B., Charvat T. T., de Jong M., Deshmukh M. V., Dirscherl G., Dolors Carrion-Salip, D’Addona D., Fischer R., Flavia Barragán, Gariepy J., Gasser G., Gianferrara T., Gossens C., Gross A., Hodson E., Hornick C. A., Hsieh H.-P., Huang C. M., Irene Gómez-Pinto, Jakupec M. A., Jakupec M. A., Janecka A., Jennerwein M., Koradi R., Kostrhunova H., Kostrhunova H., Levina A., Liu H.-K., Marchán V., Marchán V., Melacini G., Metzler-Nolte N., Mezo G., Moradell S., Moreno V., Morris R. E., Mukhopadhyay S., Novakova O., Okarvi S. M., Peacock A. F. A., Peacock A. F. A., Peacock A. F. A., Peindy N’Dongo H. W., Peter J. Sadler, Pizarro A. M., Puckett C. A., Rademaker-Lakhai J. M., Rafael de Llorens, Reubi J. C., Reubi J. C., Schaer J. C., Singh S. K., Splith K., Sun L.-C., Süss-Fink G., van Rijt S. H., van Rijt S. H., van Rijt S. H., van Rijt S. H., Vicente Marchán, Virtudes Moreno, Wang F., Wang F., Watson J. C., Wheate N. J., Wynants C., Wynants C., Zaccaro L., Zhang J., Zhang Y.   +78 more
core   +5 more sources

Aza-peptides: expectations and reality [PDF]

Proceedings of the Estonian Academy of Sciences, 2022
The replacement of the α-carbon atom in an α-amino acid structure by a nitrogen atom yields alkylcarbazic acids, also known as α-aza amino acids.
Anu Ploom, Anton Mastitski, Meeli Arujõe, Alla Troska, Jaak Järv   +4 more
doaj   +1 more source

Recent Reports of Solid-Phase Cyclohexapeptide Synthesis and Applications

Molecules, 2018
Macrocyclic peptides are privileged scaffolds for drug development and constitute a significant portion of macrocyclic drugs on the market today in fields spanning from infectious disease to oncology.
Allan M. Prior, Taylor Hori, Ashriel Fishman, Dianqing Sun   +3 more
doaj   +1 more source