Results 61 to 70 of about 24,357,552 (149)

QbD‐Based Development of Self‐Nanoemulsifying Drug Delivery System for Codelivery of Simvastatin and Ezetimibe With Enhanced In Vitro Dissolution

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
Simvastatin and ezetimibe are antihyperlipidemic agents that exhibit synergistic therapeutic effects but have poor aqueous solubility, resulting in low and variable oral bioavailability. This study aimed to develop an optimized self‐nanoemulsifying drug delivery system (SNEDDS) for the codelivery of simvastatin and ezetimibe using a quality‐by‐design ...
Sani Ega Priani, Anis Yohana Chaerunisaa, Gofarana Wilar, Iyan Sopyan, Mozhgan Afshari   +4 more
wiley   +1 more source

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Molecules, 2020
Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by ...
Mohsin Kazi, Ahmad A. Shahba, Saad Alrashoud, Majed Alwadei, Abdelrahman Y. Sherif, Fars K. Alanazi   +5 more
doaj   +1 more source

Next‐Generation Oral Delivery Systems: Phytosomal Hinokitiol Tablets via REGEMAT 3D Bioprinter‐Based 3D Printing for Enhanced Bioavailability

Scientifica, Volume 2025, Issue 1, 2025.
The administration of hinokitiol, a natural bioactive compound with promising therapeutic potential, particularly against breast cancer, faces notable challenges related to its poor solubility and low bioavailability, limiting its clinical applications.
Turky Omar Asar, Ghada A. Milibary, Alshaimaa M. Almehmady, Waleed Y. Rizg, Raed I. Felimban, Fuad H. Alnadwi, Abdelsattar M. Omar, Khalid M. El-Say, Tarek A. Ahmed, Pradeep Kumar Bolla   +9 more
wiley   +1 more source

β‐Sitosterol—Dietary sources and role in cancer and diabetes management

Food Science &Nutrition, Volume 12, Issue 11, Page 8870-8886, November 2024.
This review aims to discuss the dietary sources and variations of β‐sitosterol in food crops and how it can successfully prevent cancer and diabetes, including the mechanism underlying these benefits. We also discuss the research gaps and provide our perspective on future research to propose β‐sitosterol as a nutraceutical candidate to prevent human ...
Karthikeyan Adhimoolam, Anjana Sureshbabu, Elena Smirnova, Pandiyan Muthuramalingam, Cat Tuong Do Thi, Kalaiselvi Senthil, Taesun Min   +6 more
wiley   +1 more source

Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons

Small Science, Volume 4, Issue 11, November 2024.
The development of drug delivery systems is revolutionizing therapeutic progress by ensuring precise targeting and optimal drug concentrations. Nanocarriers, with their customizable properties and controlled release, overcome biological barriers to improve treatment outcomes. This study explores the potential of integrating artificial intelligence with
Minhye Kim, Myeongyeon Shin, Yaping Zhao, Mrinmoy Ghosh, Young‐Ok Son   +4 more
wiley   +1 more source

Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of Garcinia kola seeds ethanolic extract: formulation and in vivo antimalarial activity. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Garcinia kola seeds are widely used in Congolese traditional medicine to treat uncomplicated malaria. While the ethanolic extract of these seeds (GK) is reputed for oral antimalarial activity, some of its constituents have shown poor water ...
Grady K. Mukubwa, Christian I. Nkanga, Aristote B. Buya, Jérémie K. Mbinze, Rui W.M. Krause, Patrick B. Memvanga   +5 more
doaj  

A Review: Surface Engineering of Lipid‐Based Drug Delivery Systems

Small, Volume 20, Issue 43, October 24, 2024.
Lipid‐based nanoparticles are effective drug‐delivery systems primarily consisting of liposomes and membrane‐based nanoparticles. The potential of liposomes can be improved through surface modification. Liposomes can be transformed into biomimetic nanoparticles by coating them with various cell membranes originating from immune cells, circulatory cells,
Dhaval Patel, Jyoti Solanki, Mafatlal M. Kher, Aharon Azagury   +3 more
wiley   +1 more source

Nanomedicine Therapies for Pediatric Diseases

WIREs Nanomedicine and Nanobiotechnology, Volume 16, Issue 5, September/October 2024.
This review highlights the unique challenges in pediatric drug therapy and emphasizes the potential of nanomedicines in addressing these challenges, detailing their properties, Food and Drug Administration‐approved applications, and preclinical studies that may translate to clinical practice in treating pediatric diseases.
Shicheng Yang, Kushi Aggarwal, Jillian Jurczyszak, Needa Brown, Srinivas Sridhar   +4 more
wiley   +1 more source

Self-Nanoemulsifying Drug Delivery System of Morin: A New Approach for Combating Acute Alcohol Intoxication [PDF]

Jiamin Mao,1,2 Xiaoyuan Liu,2 Lie Zhang,1 Yu Chen,2 Shiyu Zhou,2 Yujiao Liu,2 Jing Ye,2 Xiaohong Xu,2 Quan Zhang1– 4 1Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, People’s Republic of China ...
Liu X, Liu Y, Zhou S, Chen Y, Zhang L, Xu X, Zhang Q, Mao J, Ye J   +8 more
core  

Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids

Small Science, Volume 4, Issue 7, July 2024.
In this review, the development of smart cationic lipids, typically formed via molecular hybridization of a lipid with a known bioactive moiety, is summarized. These multifunctional lipids may be considered as functional excipients, which may enhance the biological activity of certain drugs, and/or possess additional functionality such as fusogenic ...
Pushpa Ragini S, Rajkumar Banerjee, Calum J. Drummond, Charlotte E. Conn   +3 more
wiley   +1 more source