Results 1 to 10 of about 5,620 (124)

Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism [PDF]

Frontiers in Immunology, 2023
Alterations in macrophage (Mφ) polarization, function, and metabolic signature can foster development of chronic diseases, such as autoimmunity or fibrotic tissue remodeling. Thus, identification of novel therapeutic agents that modulate human Mφ biology
Katrin Peckert-Maier, Andreas B. Wild, Laura Sprißler, Maximilian Fuchs, Philipp Beck, Jean-Philippe Auger, Pia Sinner, Astrid Strack, Petra Mühl-Zürbes, Ntilek Ramadan, Meik Kunz, Meik Kunz, Gerhard Krönke, Lena Stich, Alexander Steinkasserer, Dmytro Royzman   +15 more
doaj   +4 more sources

Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages [PDF]

Frontiers in Immunology, 2022
To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated ...
Dmytro Royzman, Katrin Peckert-Maier, Lena Stich, Christina König, Andreas B. Wild, Miyuki Tauchi, Christian Ostalecki, Franklin Kiesewetter, Stefan Seyferth, Geoffrey Lee, Sabine A. Eming, Maximilian Fuchs, Meik Kunz, Meik Kunz, Ewa K. Stürmer, Eva M. J. Peters, Carola Berking, Elisabeth Zinser, Alexander Steinkasserer   +18 more
doaj   +5 more sources

Soluble CD83 Regulates Dendritic Cell–T Cell Immunological Synapse Formation by Disrupting Rab1a-Mediated F-Actin Rearrangement [PDF]

Frontiers in Cell and Developmental Biology, 2021
Dendritic cell–T cell (DC-T) contacts play an important role in T cell activation, clone generation, and development. Regulating the cytoskeletal protein rearrangement of DCs can modulate DC-T contact and affect T cell activation.
Wei Lin, Shuping Zhou, Meng Feng, Yong Yu, Qinghong Su, Xiaofan Li   +5 more
doaj   +5 more sources

Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner [PDF]

Frontiers in Immunology, 2019
Interference with autoimmune-mediated cytokine production is a key yet poorly developed approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis.
Dmytro Royzman, Darja Andreev, Lena Stich, Manfred Rauh, Tobias Bäuerle, Stephan Ellmann, Louis Boon, Markus Kindermann, Katrin Peckert, Aline Bozec, Georg Schett, Alexander Steinkasserer, Elisabeth Zinser   +12 more
doaj   +6 more sources

The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis [PDF]

Frontiers in Immunology, 2022
Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp3 was
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B. Wild, Elisabeth Zinser, Petra Mühl-Zürbes, Evan Jones, Susanne Adam, Silke Frey, Maximilian Fuchs, Meik Kunz, Meik Kunz, Tobias Bäuerle, Lisa Nagel, Georg Schett, Aline Bozec, Alexander Steinkasserer   +17 more
doaj   +4 more sources

The expression and characterization of functionally active soluble CD83 by Pichia pastoris using high-density fermentation. [PDF]

PLoS ONE, 2014
CD83 is a highly glycosylated type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. CD83 is upregulated during dendritic cell (DC) maturation, which is critical for the initiation of adaptive immune responses.
Yugang Guo, Rui Li, Xiaoping Song, Yongjun Zhong, Chenguang Wang, Hao Jia, Lidan Wu, Dong Wang, Fang Fang, Jiajia Ma, Wenyao Kang, Jie Sun, Zhigang Tian, Weihua Xiao   +13 more
doaj   +5 more sources

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells [PDF]

Frontiers in Immunology, 2018
Soluble CD83 (sCD83) is the extracellular domain of the membrane-bound CD83 molecule, and known for its immunoregulatory functions. Whether and how sCD83 participates in the pathogenesis of uveitis, a serious inflammatory disease of the eye that can ...
Wei Lin, Wei Lin, Wei Lin, Konrad Buscher, Konrad Buscher, Beibei Wang, Zhichao Fan, Nannan Song, Peng Li, Yingying Yue, Bingqing Li, Cuiling Li, Hongsheng Bi   +12 more
doaj   +5 more sources

Commentary: Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells [PDF]

Frontiers in Immunology, 2018
Mariana Pereira Pinho, José Alexandre Marzagão Barbuto   +1 more
doaj   +4 more sources

Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property. [PDF]

Int J Biol Sci, 2020
Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in the alleviation of experimental AR.
Wu YJ, Song YN, Geng XR, Ma F, Mo LH, Zhang XW, Liu DB, Liu ZG, Yang PC.   +8 more
europepmc   +4 more sources

Reduced tolerogenic factor sCD83 in NMOSD and relapsing MOGAD: a potential new therapeutic pathway [PDF]

Frontiers in Immunology
BackgroundNeuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are autoimmune central nervous system disorders with poorly understood immune pathways. CD83 plays a crucial role in the
Ariel Rechtman, Ariel Rechtman, Omri Zveik, Omri Zveik, Lyne Shweiki, Lyne Shweiki, Garrick Hoichman, Garrick Hoichman, Garrick Hoichman, Tal Friedman-Korn, Tal Friedman-Korn, Livnat Brill, Livnat Brill, Adi Vaknin-Dembinsky, Adi Vaknin-Dembinsky   +14 more
doaj   +2 more sources