Results 31 to 40 of about 5,620 (124)
Frontiers in Immunology, 2019 The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser +8 more
doaj +1 more source
The soluble form of CD83 dramatically changes the cytoskeleton of dendritic cells
Immunobiology, 2004 CD83 is the best-known surface marker for mature dendritic cells (DC) and recently we could show that a soluble form of CD83 inhibits DC maturation. In addition, this soluble form inhibits DC-mediated T cell proliferation in vitro and in vivo. Furthermore, several viruses induce CD83 degradation or shedding in infected DC.
Nicole, Kotzor +3 more
openaire +2 more sources
Involvement of Caveolin-1 in CD83 Internalization in Mouse Dendritic Cells
Cell Transplantation, 2015 To become potent T-cell stimulators, DCs need to mature. Treatment with soluble CD83 (sCD83) induces immune tolerance and protects against transplant rejection by maintaining dendritic cells in an immature, tolerogenic state.
Yuejing Yang +4 more
doaj +1 more source
Eukaryotic expression of functionally active recombinant soluble CD83 from HEK 293T cells
Immunobiology, 2010 The cell surface protein CD83 belongs to the immunoglobulin super family and is highly expressed on mature dendritic cells (DCs). A membrane bound and a soluble form of CD83 (sCD83) have been described. Previously, the isolation of a purified recombinant sCD83 molecule from bacterial cultures using high pressure liquid chromatography was reported. This
Christine, Staab +3 more
openaire +2 more sources
Shed GP of Ebola virus triggers immune activation and increased vascular permeability. [PDF]
PLoS Pathogens, 2014 During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE.
Beatriz Escudero-Pérez +4 more
doaj +1 more source
Development of an adjuvanted nanoparticle vaccine against influenza virus, an in vitro study.
PLoS ONE, 2020 Influenza is an infectious respiratory illness caused by influenza viruses. Despite yearly updates, the efficacy of influenza vaccines is significantly curtailed by the virus antigenic drift and antigenic shift.
Kamonthip Rungrojcharoenkit +7 more
doaj +1 more source
NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
Scientific Reports, 2017 Natural killer (NK) cells represent a subset of lymphocytes that contribute to innate immunity and have been reported to play a role in autoimmune uveitis. However, the mechanisms regulating NK cellular function in this condition remain unclear.
Wei Lin +8 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley +1 more source
Age‐related differences in mRNA vaccine immunogenicity and adjuvancy
Immunology &Cell Biology, EarlyView.Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni +12 more
wiley +1 more source
BMC Immunology, 2008 Background Dendritic cells (DCs) are antigen presenting cells capable of inducing innate and adaptive immune responses. According to the stimulus and their maturation state, DCs induce immunogenic or tolerogenic responses.
Delézay Olivier +7 more
doaj +1 more source