Results 41 to 50 of about 5,620 (124)

Topical Application of Soluble CD83 Induces IDO-Mediated Immune Modulation, Increases Foxp3+ T Cells, and Prolongs Allogeneic Corneal Graft Survival [PDF]

The Journal of Immunology, 2013
Abstract Modulation of immune responses is one of the main research aims in transplant immunology. In this study, we investigate the local immunomodulatory properties of soluble CD83 (sCD83) at the graft-host interface using the high-risk corneal transplantation model.
Felix Bock, Susanne Rössner, Jasmine Onderka, Matthias Lechmann, PALLOTTA, MARIA TERESA, FALLARINO, Francesca, Louis Boon, Charles Nicolette, Mark A. DeBenedette, Irina Y. Tcherepanova, GROHMANN, Ursula, Alexander Steinkasserer, Claus Cursiefen, Elisabeth Zinser   +13 more
openaire   +3 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source

New Role of P. brasiliensis α-Glucan: Differentiation of Non-conventional Dendritic Cells

Frontiers in Microbiology, 2019
The cell wall has a critical role in the host immune response to fungal pathogens. In this study, we investigated the influence of two cell wall fractions of the dimorphic fungi Paracoccidioides brasiliensis (Pb) in the in vitro generation of monocyte ...
Ana Camila Oliveira Souza, Cecília Favali, Naiara Caroline Soares, Natalia Machado Tavares, Márcio Sousa Jerônimo, Paulo Henrique Veloso Junior, Clara Luna Marina, Claire Santos, Cláudia Brodskyn, Anamelia Lorenzetti Bocca   +9 more
doaj   +1 more source

HLA‐DRB1 Allelic Combinations Differentially Shape Dendritic Cell Antigen Presentation Enhanced by Tumour Cell Line Lysate‐Pulsing

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT The anti‐tumour immune response plays a pivotal role in eliminating tumour cells, with the presence of tumour‐infiltrating lymphocytes (TILs) often correlated with improved patient outcomes. Among these, CD4+ T lymphocytes act as key orchestrators of the immune response, functioning as effector and regulatory cells, and are essential for ...
Gonzalo Lázaro, Juan A. Cedano, Maitane Faus, Carme Roura‐Mir, Laia Garrigós, José Pérez‐García, Javier Román‐García, Javier Cortés, Andrea Aran, Mercè Martí   +9 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals

Beilstein Journal of Organic Chemistry, 2014
The n−3 fatty acids are not produced by mammals, although they are essential for hormone synthesis and maintenance of cell membrane structure and integrity.
Éva Rajnavölgyi, Renáta Laczik, Viktor Kun, Lajos Szente, Éva Fenyvesi   +4 more
doaj   +1 more source

Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity

Journal of Experimental & Clinical Cancer Research, 2019
Background Soluble fibrinogen-like protein 2 (sFGL2), a secretory protein expressed by regulatory T cells (Tregs) with immunosuppressive activity, is highly expressed in both the peripheral blood and tumor tissue of patients with hepatocellular carcinoma
Muyang Yang, Zhongwei Zhang, Jiajia Chen, Mengying Xu, Jiaquan Huang, Ming Wang, Weina Li, Xiaoyang Wan, Man-Fung Yuen, Xiaoping Luo, Dong Xi, Qin Ning   +11 more
doaj   +1 more source

A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera [PDF]

International Immunology, 2001
CD83 is an inducible glycoprotein expressed predominantly by dendritic cells (DC) and B lymphocytes. Expression of membrane CD83 (mCD83) is widely used as a marker of differentiated/activated DC but its function and ligand(s) are presently unknown. We report the existence of a soluble form of CD83 (sCD83).
Hock, BD, Kato, M, McKenzie, JL, Hart, DNJ   +3 more
openaire   +3 more sources