Results 1 to 10 of about 15,414 (258)

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

Molecular Pain, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Brandes Ralf P, Fleming Ingrid, Angioni Carlo, Fischer Michael J, Altenrath Kai, Coste Ovidiu, Sisignano Marco, Brenneis Christian, Reeh Peter W, Woolf Clifford J, Geisslinger Gerd, Scholich Klaus   +11 more
doaj   +11 more sources

Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase [PDF]

Journal of Lipid Research, 2011
Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. These trans-epoxy hydroxy eicosanoids play a role in a variety of physiological processes, including inflammation, neurotransmission, and ...
Annette Cronin, Martina Decker, Michael Arand   +2 more
doaj   +5 more sources

Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages [PDF]

iScience, 2023
Summary: Soluble epoxide hydrolase is a widely distributed bifunctional enzyme that contains N-terminal phosphatase (N-phos) and C-terminal epoxide hydrolase (C-EH) domains.
Feng Liu, Xueying Diao, Haolun Cong, Eriko Suzuki, Keiji Hasumi, Hiroshi Takeshima   +5 more
doaj   +2 more sources

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury [PDF]

Frontiers in Pharmacology
Pharmacological inhibition of soluble epoxide hydrolase has been shown to attenuate lung injury development in rodents exposed to bacterial lipopolysaccharide. To investigate if these effects can be reproduced in larger animals, we tested soluble epoxide
Niklas Larsson, Cindy B. McReynolds, Sung Hee Hwang, Debin Wan, Jun Yang, Richard Lindberg, Stefan Lehtipalo, Jonas Claesson, Amanda Irgum Liljeström, Alicia Lind, Anders Brolin, Martin Isaksson Mettävainio, Bruce D. Hammock, Christophe Morisseau, Malin L. Nording, Malin L. Nording   +15 more
doaj   +2 more sources

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice. [PDF]

PLoS ONE, 2016
AIM:20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis.
Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Christina Westphal, Dennis Gürgen, Rusan Ali Catar, Aurelie Philippe, Kaiyin Wu, Gordana Bubalo, Michael Rothe, Steven M Weldon, Duska Dragun, Wolf-Hagen Schunck   +14 more
doaj   +7 more sources

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

Frontiers in Pharmacology, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Bomina Park, Bomina Park, Timothy W. Corson, Timothy W. Corson, Timothy W. Corson   +4 more
doaj   +3 more sources

The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids [PDF]

Frontiers in Pharmacology
Arachidonic acid (AA) has three main metabolic pathways: the cycloxygenases (COXs) pathway, the lipoxygenases (LOXs) pathway, and the cytochrome P450s (CYPs) pathway. AA produces epoxyeicosatrienoic acids (EETs) through the CYPs pathway.
Shan Jiang, Shan Jiang, Siyi Han, Dao Wen Wang, Dao Wen Wang   +4 more
doaj   +2 more sources

Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase. [PDF]

J Med Chem
Schönfeld J, Brunst S, Ciomirtan L, Willmer L, Chromik MA, Kumar A, Froemel T, Liebisch N, Hackspacher A, Ehrler JHM, Wintermeier L, Hesse C, Fiedler J, Heering J, Freitag H, Zardo P, Fieguth HG, Brüggerhoff A, Jakob J, Häupl B, Weizel L, Kaiser A, Schubert-Zsilavecz M, Oellerich T, Fleming I, Schebb NH, Fürst R, Kannt A, Knapp S, Proschak E, Hiesinger K.   +30 more
europepmc   +2 more sources

A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction

Scientific Reports, 2022
Myocardial infarction is still a life-threatening disease, even though its prognosis has been improved through the development of percutaneous coronary intervention and pharmacotherapy.
Takahiro Kitsuka, Aya Shiraki, Jun-ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node   +5 more
doaj   +1 more source

The impact of the soluble epoxide hydrolase cascade on periodontal tissues

Frontiers in Dental Medicine, 2023
Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla, Thomas E. Van Dyke, Thomas E. Van Dyke   +2 more
doaj   +1 more source