Results 1 to 10 of about 16,002 (212)

Soluble Epoxide Hydrolase and Diabetes Complications

International Journal of Molecular Sciences, 2022
Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke.
Natasha Z. Anita, Walter Swardfager
openaire   +3 more sources

Soluble Epoxide Hydrolase

Asian Journal of Pharmaceutical Research and Development
Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits.
Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive   +4 more
openaire   +2 more sources

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension. [PDF]

Compr Physiol
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Leuillier M, Chelgham M, Messaoudi H, Tu L, Ménoret S, Thuillet R, Groussard D, Lillich FF, Ottaviani M, Nicol L, Mulder P, Humbert M, Richard V, Anegon I, Morisseau C, Proschak E, Guignabert C, Bellien J.   +17 more
europepmc   +2 more sources

Epoxylipids and soluble epoxide hydrolase in heart diseases

Biochemical Pharmacology, 2022
Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks.
John D, Imig, Ludek, Cervenka, Jan, Neckar   +2 more
openaire   +3 more sources

Inhibition of soluble epoxide hydrolase by natural isothiocyanates. [PDF]

Biochem Biophys Res Commun
The long-term goal of our research is to develop safe and effective soluble epoxide hydrolase (sEH) inhibitors. The objective of this study is to evaluate the potency and selectivity of six natural isothiocyanates (ITCs) as sEH inhibitors.Molecular docking was used to model likely interactions between the ligands and receptors.
Elbarbry F, Espiritu MJ, Soo K, Yee B, Taylor J.   +4 more
europepmc   +3 more sources

Mechanism of Soluble Epoxide Hydrolase [PDF]

Journal of Biological Chemistry, 1995
Two rapid assays for the soluble epoxide hydrolase (sEH) are described. First, a sensitive radiometric assay based on thin-layer chromatography of [(14)C]-cis-9,10-epoxystearic acid and its corresponding diol ((14)C]-9,10-dihydroxystearic acid) is described.
Babak Borhan, A. Daniel Jones, Franck Pinot, David F. Grant, Mark J. Kurth, Bruce D. Hammock   +5 more
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Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer's disease in mice.

Neuron, 2023
Alzheimer's disease (AD) is caused by a complex interaction between genetic and environmental factors. However, how the role of peripheral organ changes in response to environmental stimuli during aging in AD pathogenesis remains unknown. Hepatic soluble
Yu Wu, Jinghua Dong, Yang Dai, Minzhen Zhu, Mengyao Wang, Yuan Zhang, Yi-da Pan, Xin-rui Yuan, Zhipeng Guo, Chen-xi Wang, Yuan-qing Li, Xinhong Zhu   +11 more
semanticscholar   +1 more source

Aflatoxin B1 Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity

International Journal of Molecular Sciences, 2023
Parkinson’s disease (PD) is an increasingly common neurodegenerative movement disorder with contributing factors that are still largely unexplored and currently no effective intervention strategy.
Weicang Wang, Yuxin Wang, K. Wagner, R. Lee, S. Hwang, C. Morisseau, H. Wulff, B. Hammock   +7 more
semanticscholar   +1 more source

The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

Journal of Translational Medicine, 2023
Background Patients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory cytokines.
A. Luo, Zifeng Wu, Shan Li, C. McReynolds, Di Wang, Hanyu Liu, Chao Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, B. Hammock, K. Hashimoto, Chun Yang   +13 more
semanticscholar   +1 more source

Insights into the inhibitory activities of neolignans and diarylnonanoid derivatives from nutmeg (Myristica fragrans Houtt.) seeds on soluble epoxide hydrolase using in vitro and in silico approaches

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Two new neolignans, myrifralignans F–G (14 and 18), four new diarylnonanoid derivatives, myrifragranones A–D (21–24), and 18 known compounds were isolated and structurally elucidated from nutmeg (Myristica fragrans Houtt.) seeds.
Vũ Thị Oanh, N. V. Phong, B. Min, Seo-Young Yang, Jeong Ah Kim   +4 more
semanticscholar   +1 more source