Results 1 to 10 of about 111,543 (344)
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Frontiers in Pharmacology, 2013 Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
doaj +2 more sources
eLife, 2022 Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo +8 more
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European Journal of Medical Research, 2023 Purpose To evaluate the effect of postoperative utilization of somatostatin after definitive surgery for duodenal fistula (DF) in preventing a recurrence.
Weiliang Tian +5 more
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Biomedicines, 2021 Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on ...
Maria Isabel del Olmo-Garcia +5 more
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Frontiers in Endocrinology, 2021 Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel +5 more
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SCN 1A /Na V 1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models [PDF]
Epilepsia, Wiley, 2019, 60 (S3), 2022 Pathogenic SCN1A/NaV1.1 mutations cause well defined epilepsies, including Genetic Epilepsy with Febrile Seizures Plus (GEFS+) and the severe epileptic encephalopathy Dravet syndrome. In addition, they cause a severe form of migraine with aura, Familial Hemiplegic Migraine.
arxiv +1 more source
Somatostatin Analogs in Clinical Practice: A Review
International Journal of Molecular Sciences, 2020 Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors.
Mariana Gomes-Porras +2 more
semanticscholar +1 more source
Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]
PLoS ONE, 2014 Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand +7 more
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Current diagnosis and treatment of acute pancreatitis in China: a real-world, multicenter study
BMC Gastroenterology, 2021 Background Efficacy of pancreatic enzyme inhibitors in acute pancreatitis (AP) is unclear in China. Aims We aimed to present the current status of AP and evaluate the efficacy of pancreatic enzyme inhibitors in a larger population in China.
Chuandong Sun +3 more
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Frontiers in Psychiatry, 2022 Chronic stress is a major risk factor for developing mental illnesses and cognitive deficiencies although stress-susceptibility varies individually. In a recent study, we established the connection between chronic social defeat stress (CSDS) and impaired
Maria L. Serradas +2 more
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