Results 1 to 10 of about 136,487 (285)

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

open access: yeseLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo   +8 more
doaj   +1 more source

Effect of postoperative utilization of somatostatin on clinical outcome after definitive surgery for duodenal fistula

open access: yesEuropean Journal of Medical Research, 2023
Purpose To evaluate the effect of postoperative utilization of somatostatin after definitive surgery for duodenal fistula (DF) in preventing a recurrence.
Weiliang Tian   +5 more
doaj   +1 more source

Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

open access: yesBiomedicines, 2021
Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on ...
Maria Isabel del Olmo-Garcia   +5 more
doaj   +1 more source

Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World

open access: yesFrontiers in Endocrinology, 2021
Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel   +5 more
doaj   +1 more source

Age-dependent patterns of somatostatinergic neurons in sympathetic paravertebral ganglia

open access: yesСеченовский вестник, 2023
Aim. We aimed to determine the content of neurons expressing somatostatin (SST) and their colocalization with  cells expressing tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the cranial cervical ganglion (CCG) and celiac  plexus in rats ...
A. I. Emanuilov   +3 more
doaj   +1 more source

Changes in serum somatostatin level and its association with calcium metabolism indicators in patients with gastroesophageal reflux disease and spinal injuries of degenerative-dystrophic and inflammatory genesis

open access: yesGastroenterologìa, 2022
Background. The study of clinical features, factors and levels of various biologically active substances that may play an important role in the pathogenetic mechanism of gastroesophageal reflux disease (GERD) in combination with degenerative-dystrophic ...
Ye.S. Szircsak, S.A. Tsoka, Ya.F. Filak
doaj   +1 more source

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]

open access: yesPLoS ONE, 2014
Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand   +7 more
doaj   +1 more source

Current diagnosis and treatment of acute pancreatitis in China: a real-world, multicenter study

open access: yesBMC Gastroenterology, 2021
Background Efficacy of pancreatic enzyme inhibitors in acute pancreatitis (AP) is unclear in China. Aims We aimed to present the current status of AP and evaluate the efficacy of pancreatic enzyme inhibitors in a larger population in China.
Chuandong Sun   +3 more
doaj   +1 more source

Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]

open access: yes, 2017
Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core   +2 more sources

Somatostatin receptor expression in parathyroid neoplasms

open access: yesEndocrine Connections, 2019
Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall   +6 more
doaj   +1 more source

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