Results 1 to 10 of about 115,117 (314)

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
doaj   +1 more source

Effect of postoperative utilization of somatostatin on clinical outcome after definitive surgery for duodenal fistula

European Journal of Medical Research, 2023
Purpose To evaluate the effect of postoperative utilization of somatostatin after definitive surgery for duodenal fistula (DF) in preventing a recurrence.
Weiliang Tian, Risheng Zhao, Shikun Luo, Xi Xu, Guoping Zhao, Zheng Yao   +5 more
doaj   +1 more source

Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

Biomedicines, 2021
Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on ...
Maria Isabel del Olmo-Garcia, Stefan Prado-Wohlwend, Alexia Andres, Jose M. Soriano, Pilar Bello, Juan Francisco Merino-Torres   +5 more
doaj   +1 more source

Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World

Frontiers in Endocrinology, 2021
Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel, Isabel Tena, Isabel Tena, Abhishek Jha, David Taieb, Karel Pacak   +5 more
doaj   +1 more source

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. [PDF]

PLoS ONE, 2014
Hair cells and spiral ganglion neurons of the mammalian auditory system do not regenerate, and their loss leads to irreversible hearing loss. Aminoglycosides induce auditory hair cell death in vitro, and evidence suggests that phosphatidylinositol-3 ...
Yves Brand, Vesna Radojevic, Michael Sung, Eric Wei, Cristian Setz, Andrea Glutz, Katharina Leitmeyer, Daniel Bodmer   +7 more
doaj   +1 more source

Current diagnosis and treatment of acute pancreatitis in China: a real-world, multicenter study

BMC Gastroenterology, 2021
Background Efficacy of pancreatic enzyme inhibitors in acute pancreatitis (AP) is unclear in China. Aims We aimed to present the current status of AP and evaluate the efficacy of pancreatic enzyme inhibitors in a larger population in China.
Chuandong Sun, Zhu Li, Zheng Shi, Guichen Li   +3 more
doaj   +1 more source

Long-term changes of parvalbumin- and somatostatin-positive interneurons of the primary motor cortex after chronic social defeat stress depend on individual stress-vulnerability

Frontiers in Psychiatry, 2022
Chronic stress is a major risk factor for developing mental illnesses and cognitive deficiencies although stress-susceptibility varies individually. In a recent study, we established the connection between chronic social defeat stress (CSDS) and impaired
Maria L. Serradas, Valentin Stein, Anne-Kathrin Gellner   +2 more
doaj   +1 more source

Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

Frontiers in Neuroscience, 2022
Substance use disorders are a debilitating group of psychiatric disorders with a high degree of comorbidity with major depressive disorder. Sleep and circadian rhythm disturbances are commonly reported in people with substance use disorder and major ...
Jake Valeri, Jake Valeri, Sinead M. O’Donovan, Wei Wang, David Sinclair, Ratna Bollavarapu, Barbara Gisabella, Barbara Gisabella, Donna Platt, Donna Platt, Craig Stockmeier, Craig Stockmeier, Harry Pantazopoulos, Harry Pantazopoulos   +13 more
doaj   +1 more source

The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis

BMC Infectious Diseases, 2005
Background The neuropeptide somatostatin is one of the major regulatory peptides in the central nervous system and the digestive tract. Our recent work has delineated an association between fibrosis and low levels of endogenous somatostatin plasma levels
Peeters Theo, Depoortere Inge, Vrolix Gunther, Chatterjee Shyama, Van Marck Eric   +4 more
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Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures

Frontiers in Molecular Neuroscience, 2022
Epileptic seizures result in pronounced over-expression of neuropeptide Y (NPY). In vivo and in vitro studies revealed that NPY exerts potent anticonvulsive actions through presynaptic Y2 receptors by suppressing glutamate release from principal neurons.
Meinrad Drexel, Günther Sperk
doaj   +1 more source