Results 31 to 40 of about 76,426 (249)

On implications of somatostatin in diabetic retinopathy

Neural Regeneration Research
Somatostatin, a naturally produced neuroprotective peptide, depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.
Yanhong Fang, Qionghua Wang, Youjian Li, Li Zeng, Jian Liu, Kepeng Ou   +5 more
doaj   +1 more source

Totalsynthese von Somatostatin-28 (Big-Somatostatin) / Total Synthesis of Somatostatin-28 (Big Somatostatin)

Zeitschrift für Naturforschung B, 1980
The total synthesis of the octacosapeptide corresponding to the proposed primary structure of porcine somatostatin-28, a possible precursor of somatostatin, is described. The primary structure of somatostatin-28 corresponds to that of somatostatin elongated at the N-terminus by a tetradecapeptide sequence.
E. Wünsch, L. Moroder, M. Gemeiner, E. Jaeger, A. Ribet, L. Pradayrol, N. Vaysse   +6 more
openaire   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ1–42 and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

Frontiers in Aging Neuroscience, 2018
A combination of low cerebrospinal fluid (CSF) Amyloid β1–42 (Aβ1–42) and high Total-Tau (T-Tau) and Phosphorylated-Tau (P-Tau) occurs at a prodromal stage of Alzheimer’s disease (AD) and recent findings suggest that network abnormalities and ...
Emmanuelle Duron, Emmanuelle Duron, Emmanuelle Duron, Emmanuelle Duron, Jean-Sébastien Vidal, Jean-Sébastien Vidal, Dominique Grousselle, Audrey Gabelle, Sylvain Lehmann, Florence Pasquier, Stéphanie Bombois, Luc Buée, Bernadette Allinquant, Susanna Schraen-Maschke, Susanna Schraen-Maschke, Christiane Baret, Anne-Sophie Rigaud, Anne-Sophie Rigaud, Olivier Hanon, Olivier Hanon, Jacques Epelbaum, Jacques Epelbaum   +21 more
doaj   +1 more source

Somatostatin and somatostatin receptors in Cushing's disease [PDF]

Molecular and Cellular Endocrinology, 2008
Cushing's disease is caused by an ACTH secreting pituitary adenoma. Surgery is the treatment of choice and cure rates between 60 and 90% are reported. For patients in which surgery fails, effective medical treatment options are needed. Somatostatin (SS) receptors (sst) are expressed on normal and tumoral corticotroph cells.
openaire   +4 more sources

Somatostatin and Somatostatin Receptors in Tumour Biology

International Journal of Molecular Sciences, 2023
Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
openaire   +2 more sources

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Recent advances in neuropeptide-related omics and gene editing: Spotlight on NPY and somatostatin and their roles in growth and food intake of fish

Frontiers in Endocrinology, 2022
Feeding and growth are two closely related and important physiological processes in living organisms. Studies in mammals have provided us with a series of characterizations of neuropeptides and their receptors as well as their roles in appetite control ...
Xiaozheng Yu, Haijun Yan, Wensheng Li
doaj   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes

Frontiers in Pharmacology
Glucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses.
Emily G. Hoffman, Ninoschka C. D’Souza, Richard T. Liggins, Michael C. Riddell   +3 more
doaj   +1 more source