Results 111 to 120 of about 605,792 (294)

Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly [PDF]

, 2015
D.A.C. was supported by the Nicolás Monardes program of the Andalusian Ministry of Health (C-0015-2014) and by a grant from the Andalusian Ministry of Science and Innovation (CTS-7478).
Balcerzyk, M, Cano, DA, Castano, JP, Fernandez-Maza, L, Ibanez-Costa, A, Leal-Campanario, R, Leal-Cerro, A, Luque, RM, Martin-Rodriguez, JF, Munoz-Bravo, JL, Soto-Moreno, A, Venegas-Moreno, E   +11 more
core   +3 more sources

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Acromegaly is a rare chronic disease caused by excessive secretion of growth hormone. Even with biochemical control, hormonal imbalance may lead to cerebral changes. This study aimed to evaluate the presence of white matter hyperintensities (WMHs) in patients with acromegaly.
Denise Costa, Giada Giuliani, Valentina Martines, Chiara Pellicano, Valeria Mercuri, Vittorio Di Piero, Patrizia Gargiulo, Camilla Virili   +7 more
wiley   +1 more source

Somatostatin Analogs Therapy in Gastroenteropancreatic Neuroendocrine Tumors: Current Aspects and New Perspectives

Frontiers in Endocrinology, 2013
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors that present many clinical features secreting peptides and neuroamines that cause distinct clinical syndromes such as carcinoid syndrome.
R. Baldelli, A. Barnabei, L. Rizzà, A. Isidori, F. Rota, P. D. Giacinto, A. Paoloni, F. Torino, S. Corsello, A. Lenzi, M. Appetecchia   +10 more
semanticscholar   +1 more source

The influence of somatostatin analogues on the incidence of pancreatic fistulas and postoperative morbidity in patients undergoing pancreatic resection: A Bayesian network meta-analysis.

PLoS ONE
BackgroundPancreatic resection is a critical treatment for pancreatic cancer and other pancreatic diseases. Somatostatin analogs are commonly used to prevent complications following pancreatic resection, but their efficacy and safety remain debated ...
Zonghao Hou, Shengxiang Hou, Zhixin Wang, Haijiu Wang, Manjun Deng, Haining Fan   +5 more
doaj   +1 more source

Gastrin and cholecystokinin peptide-based radiopharmaceuticals: an in vivo and in vitro comparison [PDF]

, 2011
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest.
ACCARDO, ANTONELLA, Aloj L., Arra C, Aurilio M, Barbieri A, MORELLI, GIANCARLO, Tarallo L, TESAURO, DIEGO, Tornesello AL   +8 more
core   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1 [PDF]

, 2002
The present study was intended to gain additional information on the growth regulation of prostate by somatostatin\ud (SRIF) and the intracellular events involved.
Angulo, Javier, Buscail, Louis, Colás Escudero, Begoña, Lopez, José Ignacio, López Ruiz, María del Pilar, Martín Orozco, Rosa María, Prieto Villapún, Juan Carlos, Ropero, Rosa María, Susini, Christiane, Valencia Torralba, Ana Montserrat, Zapata, Pedro Darío   +10 more
core   +3 more sources

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Expression of somatostatin receptors in hemangioblastomas associated with von Hippel-Lindau disease as a novel diagnostic, therapeutic, and follow-up opportunity: A case report and literature review

Archives of Endocrinology and Metabolism
SUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors.
Eloá Pereira Brabo, Sergio Altino de Almeida, Patrícia Piazza Rafful, Paulo Henrique Rosado-de-Castro, Leonardo Vieira Neto   +4 more
doaj   +1 more source

Practice Guidelines for the Diagnosis and Treatment of Subepithelial Lesion Observed in Upper Gastrointestinal Endoscopy

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Subepithelial lesions (SELs) of the upper gastrointestinal tract are commonly detected during endoscopic examinations and encompass a broad spectrum of benign, potentially malignant, and malignant tumors. While most SELs are asymptomatic and incidentally found, accurate diagnosis remains challenging due to their subepithelial location ...
Beom Jin Kim, Seung Joo Kang, Su Youn Nam, Chang Seok Bang, Byung‐Hoon Min, Sung Eun Kim, Seung Young Kim, Hyunchul Lim, Chung Hyun Tae, Moon Won Lee, Seung Han Kim, Sang Hoon Kim, Jong Yeul Lee, Byung‐Wook Kim, Jeong Seop Moon, Jong‐Jae Park, Hwoon‐Yong Jung, Korean College of Helicobacter and Upper Gastrointestinal Research   +17 more
wiley   +1 more source