Results 81 to 90 of about 605,792 (294)

Estrogens Modulate Somatostatin Receptors Expression and Synergize With the Somatostatin Analog Pasireotide in Prostate Cells

Frontiers in Pharmacology, 2019
Prostate cancer (PC) is one of the most frequently diagnosed cancers and a leading cause of cancer-related deaths in Western society. Current PC therapies prevalently target the functions of androgen receptor (AR) and may only be effective within short ...
Valentina Rossi, Erika Di Zazzo, Giovanni Galasso, Caterina De Rosa, Ciro Abbondanza, Antonio A. Sinisi, Lucia Altucci, Antimo Migliaccio, Gabriella Castoria   +8 more
doaj   +1 more source

Expression of Somatostatin Receptor Subtypes (SSTR-1–SSTR-5) in Pediatric Hematological and Oncological Disorders

Molecules, 2020
Hematological and oncological disorders represent leading causes of childhood mortality. Neuropeptide somatostatin (SST) has been previously demonstrated in various pediatric tumors, but limited information exists on the expression and characteristics of
Kristof Harda, Zsuzsanna Szabo, Eva Juhasz, Balazs Dezso, Csongor Kiss, Andrew V. Schally, Gabor Halmos   +6 more
doaj   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Peptide receptor radionuclide therapy using radiolabeled somatostatin analogs: focus on future developments

Clinical and translational imaging, 2014
Peptide receptor radionuclide therapy (PRRT) has been shown to be an effective treatment for neuroendocrine tumors (NETs) if curative surgery is not an option. A majority of NETs abundantly express somatostatin receptors.
Sander M. Bison, M. Konijnenberg, M. Melis, S. Pool, M. Bernsen, Jaap J. M. Teunissen, D. Kwekkeboom, M. de Jong   +7 more
semanticscholar   +1 more source

High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma

International Journal of Endocrinology, 2018
The development of somatostatin analogs for the treatment of pituitary Cushing’s disease has been based on somatostatin receptor expression analyses of small cohorts of pituitary adenomas.
Felix Behling, Jürgen Honegger, Marco Skardelly, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Marcos Tatagiba, Jens Schittenhelm   +6 more
doaj   +1 more source

Targeted paclitaxel‐octreotide conjugates inhibited the growth of paclitaxel‐resistant human non‐small cell lung cancer A549 cells in vitro

Thoracic Cancer, 2021
The application of chemotherapy in non‐small cell lung cancer (NSCLC) is limited by the toxicity to normal cells and the development of multi‐drug resistance.
Yanguo Liu, Handai Xia, Yawei Wang, Wenfei Han, Jing Qin, Wenjuan Gao, Xun Qu, Xiuwen Wang   +7 more
doaj   +1 more source

Intrapancreatic accessory spleen false positive to 68Ga-Dotatoc: case report and literature review [PDF]

, 2019
Background: Intrapancreatic accessory spleen (IPAS) is an uncommon finding of pancreatic mass. Differential diagnosis with pancreatic tumor, especially with non-functional neuroendocrine tumor (NF-NET), may be very hard and sometimes it entails ...
Bellato, V., Caronna, R., Cerasari, S., Chirletti, P., Ciardi, A., Cicconi, S., Feola, T., Lancellotti, F., Muttillo, E. M., Sacco, L.   +9 more
core   +1 more source

Survival outcomes and prognostic factors of gastric carcinoma with neuroendocrine differentiation

International Journal of Cancer, EarlyView.
What's New? Although gastric carcinoma with neuroendocrine differentiation (GCNED) is associated with more aggressive features than conventional GC, its prognosis and survival remain poorly defined. To better understand survival patterns, the authors of the present study examined clinicopathological and prognostic features of GCNED patients following ...
Jinjin Li, Chenglong Wang, Yifan Shen, Zhen Huang, Jun Zhang, Siqi Rao, Youde Cao, Jiang Min   +7 more
wiley   +1 more source

Somatostatin analog therapy in delaying progression of polycystic liver disease: A meta-analysis with trial sequential analysis

iLIVER
Background and aims: Polycystic liver disease (PLD) can occur independently or in association with autosomal dominant polycystic kidney disease and has no effective medical therapy.
Mohammed S. Beshr, Rana H. Shembesh, Bisher Sawaf, Shahem Abbarh, Mohammed Abu-Rumaileh, Monica Tincopa, Muhammed Elhadi   +6 more
doaj   +1 more source

Risk factors and management of pasireotide-associated hyperglycemia in acromegaly

Endocrine Connections, 2020
Pasireotide, a multireceptor-targeted somatostatin analog with highest affinity for somatostatin receptor subtype (SST) 5, has demonstrated superio r efficacy over the SST2-preferential somatostatin analogs octreotide and lanreotide.
Mônica R Gadelha, Feng Gu, Marcello D Bronstein, Thierry C Brue, Maria Fleseriu, Ilan Shimon, Aart J van der Lely, Shoba Ravichandran, Albert Kandra, Alberto M Pedroncelli, Annamaria A L Colao   +10 more
doaj   +1 more source