Results 71 to 80 of about 4,620 (263)

Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age

open access: yesAging Cell, EarlyView.
Human skin fibroblasts in vitro preserve the memory of age and health. ABSTRACT Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite ...
Chloé Brodeau   +21 more
wiley   +1 more source

Aerobic Exercise Attenuates Autophagy‐Lysosomal Flux Deficits via β2‐AR‐Mediated ESCRT‐III Subunit CHMP4B in Mice With Human MAPT P301L

open access: yesAging Cell, EarlyView.
MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi   +12 more
wiley   +1 more source

Photosynthetic Variability of Oblačinska Sour Cherry Ecotypes under Drought. [PDF]

open access: yesPlants (Basel), 2022
Viljevac Vuletić M   +7 more
europepmc   +1 more source

Age Structure and Size Variation in Three Closely Related Species of Casque‐Headed Frogs of the Genus Trachycephalus (Hylidae: Lophyohylini)

open access: yesActa Zoologica, EarlyView.
ABSTRACT Parreira. I.P. 2025. Age structure and size variation in three closely related species of casque‐headed frogs of the genus Trachycephalus (Hylidae: Lophyohylini)—Acta zoologica (Estocolmo). This study provides insights into longevity, sexual maturity and growth curves in closely related casque‐headed treefrogs distributed across distinct ...
Isabella Parreira   +4 more
wiley   +1 more source

‘Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia’

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo   +11 more
wiley   +1 more source

Sour Cherry Pomace Valorization as a Bakery Fruit Filling: Chemical Composition, Bioactivity, Quality and Sensory Properties. [PDF]

open access: yesAntioxidants (Basel), 2023
Teslić N   +6 more
europepmc   +1 more source

Exploration of the natural dye alizarin for supercritical carbon dioxide dyeing of polyester, polyamide and cellulose acetate fibres

open access: yesColoration Technology, EarlyView.
Abstract Conventional textile dyeing utilises large amounts of water and generates significant amounts of wastewater, highlighting the need to utilise more sustainable dyeing methods. Supercritical carbon dioxide (scCO2) dyeing offers a zero‐water, zero‐wastewater alternative with reduced energy requirements and carbon dioxide recyclability. While both
Michele Schmidt   +3 more
wiley   +1 more source

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