METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2 [PDF]
Open MedicineWe aimed to explore the regulatory effects of methyltransferase-like 3 (METTL3) on diabetic retinopathy (DR) by regulating the m6A modification of SOX2 mRNA and elucidating the underlying molecular mechanism.
Chen Xiujuan +4 more
doaj +2 more sources
Expression of the stem cell markers NANOG and SOX2 in the cervical squamous carcinogenesis [PDF]
Radiology and OncologyThe aim of the present study was to assess a diagnostic potential of stem cell markers NANOG and SOX2 for classifying cervical squamous intraepithelial lesions (SILs)/cervical intraepithelial neoplasia (CIN).
Koren Miha +4 more
doaj +2 more sources
Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus [PDF]
Neural Regeneration ResearchNeural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases.
Baocheng Gao +8 more
doaj +2 more sources
High SOX2 expression as an indicator of the potential involvement of cancer stem cells in the development of cervical cancer among females with HPV infection [PDF]
CellR4, 2021 Objective: Cervical cancer ranks fourth for both incidence and mortality among females. Human papillomavirus (HPV) infection plays an important role in the pathophysiology of cervical cancer.
E. Kldiashvili +2 more
doaj +1 more source
An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development [PDF]
Open Biology, 2021 The hippocampus is a brain area central for cognition. Mutations in the human SOX2 transcription factor cause neurodevelopmental defects, leading to intellectual disability and seizures, together with hippocampal dysplasia. We generated an allelic series
Sara Mercurio +7 more
doaj +1 more source
A predicted two to tango interaction between MUC1 and SOX2: a unique opportunity to target cancer stem cells [PDF]
World Cancer Research Journal, 2022 Objective: Cancer stem cell (CSC) genes are emerging as cancer therapeutic targets. MUC1 is a cell surface-associated glycoprotein that is aberrantly over‐expressed in >60% of human cancers including breast cancer.
A. Dutta, S. Paul
doaj +1 more source
Comparative characteristic of lung cancer stem-like cells generated in vitro under different culture conditions [PDF]
The Ukrainian Biochemical Journal, 2021 Cancer stem cells (CSCs) play an important role in resistance to cancer treatment and recurrence developing. The aim of this study was to obtain cell culture of MOR line non-small cell lung cancer cells enriched in CSCs and to investigate its functional ...
O. V. Skachkova +4 more
doaj +1 more source
SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p
Cancer Biology & Therapy, 2022 Elevated SOX2 protein levels correspond to the poor prognosis of patients with esophageal squamous cell carcinoma (ESCC). Poor prognosis is closely correlated with the loss or disruption of cellular polarity; however, the relationships between SOX2 ...
Shihui Zhang +15 more
doaj +1 more source
Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]
Pharmaciana, 2019 A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi +3 more
doaj +1 more source
Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells [PDF]
Research Ideas and Outcomes, 2021 SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2).
Dao-Yin Dong, Pu-Yu Li
doaj +3 more sources