Results 11 to 20 of about 65,805 (290)
CARM1 mediates modulation of Sox2. [PDF]
PLoS ONE, 2011 Sox2 is a key component of the transcription factor network that maintains the pluripotent state of embryonic stem cells (ESCs). Sox2 is regulated by multiple post-translational modifications, including ubiquitination, sumoylation, acetylation and ...
Hai-yong Zhao +4 more
doaj +5 more sources
Specificity and application of SOX2 antibody
Poultry Science, 2020 Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. The purpose of this study was to prepare an anti-chicken Sox2 polyclonal antibody using prokaryotic expression techniques, to evaluate its ...
Longqin Wei +11 more
doaj +3 more sources
Mutations in SOX2 cause anophthalmia [PDF]
Nature Genetics, 2003 A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation.
Judy Fantes +10 more
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Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]
Journal of Biological Chemistry, 2005 Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog.
David J. Rodda +6 more
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Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis [PDF]
Obstetrics and Gynecology International, 2010 This paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas.
Oscar Gee-Wan Wong +6 more
doaj +3 more sources
Long Live Sox2: Sox2 Lasts a Lifetime [PDF]
Cell Stem Cell, 2011 Sox2 is a key transcription factor required for the maintenance of pluripotency in embryonic cells and morphogenesis of several epithelia. In this issue of Cell Stem Cell, Arnold et al. (2011) demonstrate that Sox2 marks long-lived adult stem cells to ensure homeostasis in a broad range of adult tissues.
Driessens, Grégory, Blanpain, Cédric
openaire +3 more sources
Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo [PDF]
Transgenic Research, 2018 Sox2 is a Sry-box containing family member of related transcription factors sharing homology in their DNA binding domain. Sox2 is important during different stages of development, and previously we showed that Sox2 plays an important role in branching morphogenesis and epithelial cell differentiation in lung development. The transcriptional activity of
Kim Schilders +8 more
openaire +4 more sources
Sox2: A multitasking networker [PDF]
Neurogenesis, 2014 The transcription factor Sox2 is best known as a pluripotency factor in stem and precursor cells and its expression generally correlates with an undifferentiated state. Proposed modes of action include those as classical transcription factor and pre-patterning factor with influence on histone modifications and chromatin structure. Recently, we provided
Simone Reiprich, Michael Wegner
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Sox2: Masterminding the Root of Cancer [PDF]
Cancer Cell, 2014 The transcription factor Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells. Using elegant lineage tracing strategies and genetic reporter mouse models, two studies (one of which is by Vanner and colleagues in this issue of Cancer Cell) now demonstrate that rare Sox2-expressing cells are the founding cancer
Wai Leong Tam +2 more
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Molecular & Cellular Oncology, 2020 The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells.
Maria Bååth +8 more
doaj +1 more source