Results 11 to 20 of about 70,586 (295)
CARM1 mediates modulation of Sox2. [PDF]
PLoS ONE, 2011 Sox2 is a key component of the transcription factor network that maintains the pluripotent state of embryonic stem cells (ESCs). Sox2 is regulated by multiple post-translational modifications, including ubiquitination, sumoylation, acetylation and ...
Hai-yong Zhao +4 more
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Specificity and application of SOX2 antibody
Poultry Science, 2020 Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. The purpose of this study was to prepare an anti-chicken Sox2 polyclonal antibody using prokaryotic expression techniques, to evaluate its ...
Longqin Wei +11 more
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Long Live Sox2: Sox2 Lasts a Lifetime [PDF]
Cell Stem Cell, 2011 Sox2 is a key transcription factor required for the maintenance of pluripotency in embryonic cells and morphogenesis of several epithelia. In this issue of Cell Stem Cell, Arnold et al. (2011) demonstrate that Sox2 marks long-lived adult stem cells to ensure homeostasis in a broad range of adult tissues.
Driessens, Grégory, Blanpain, Cédric
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Mutations in SOX2 cause anophthalmia [PDF]
Nature Genetics, 2003 A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation.
Judy, Fantes +10 more
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Sox2 modulation increases naïve pluripotency plasticity [PDF]
iScience, 2020 AbstractInduced pluripotency provides a tool to explore the molecular mechanisms underlying the establishment, maintenance and differentiation of naïve pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low).
Tremble, Kathryn +10 more
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Sox2: A multitasking networker [PDF]
Neurogenesis, 2014 The transcription factor Sox2 is best known as a pluripotency factor in stem and precursor cells and its expression generally correlates with an undifferentiated state. Proposed modes of action include those as classical transcription factor and pre-patterning factor with influence on histone modifications and chromatin structure. Recently, we provided
Reiprich, Simone, Wegner, Michael
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Molecular & Cellular Oncology, 2020 The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells.
Maria Bååth +8 more
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Identifying SOX2-OT transcript that is responsible for regulating SOX2 in cancer cells and embryonic stem cells [PDF]
Research Ideas and Outcomes, 2021 SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2).
Dao-Yin Dong, Pu-Yu Li
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The Sox2 transcription factor binds RNA [PDF]
Nature Communications, 2020 AbstractCertain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor critical for maintenance of pluripotency and neurogenesis, has been found associated with several lncRNAs, although it is unknown whether these interactions are direct or via other ...
Zachariah E. Holmes +6 more
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Immunohistochemical investigation of SOX2 expression in Iraqi patients with high-grade glioma [PDF]
Romanian Journal of NeurologyBackground. Gliomas, particularly high-grade gliomas, are aggressive brain tumors with poor prognosis. Sex-determining region Y-box 2 (SOX2) is a transcription factor responsible for stem cell maintenance and differentiation and has been implicated in ...
Hadeer Hashim Shams Uldeen +2 more
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