Results 21 to 30 of about 70,586 (295)
Di-san junyi daxue xuebao, 2019 Objective To explore the effect of karyopherina 2 (KPNA2) knockdown on osteosarcoma cell proliferation and angiogenesis and the possible molecular mechanism.
GE Qiaofeng +3 more
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Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo [PDF]
Transgenic Research, 2018 Sox2 is a Sry-box containing family member of related transcription factors sharing homology in their DNA binding domain. Sox2 is important during different stages of development, and previously we showed that Sox2 plays an important role in branching morphogenesis and epithelial cell differentiation in lung development. The transcriptional activity of
Kim Schilders +8 more
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Biology Open, 2020 In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia
Machiko Teramoto +7 more
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CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma [PDF]
Cancers, 2021 SOX2 is a transcription factor associated with stem cell activity in several tissues. In cancer, SOX2 expression is increased in samples from several malignancies, including glioblastoma, and high SOX2 levels are associated with the population of tumor-initiating cells and with poor patient outcome.
Ander Saenz-Antoñanzas +6 more
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Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]
Pharmaciana, 2019 A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi +3 more
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Viruses, 2020 Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII). EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and ...
Hua Yang +9 more
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Sox2: Masterminding the Root of Cancer [PDF]
Cancer Cell, 2014 The transcription factor Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells. Using elegant lineage tracing strategies and genetic reporter mouse models, two studies (one of which is by Vanner and colleagues in this issue of Cancer Cell) now demonstrate that rare Sox2-expressing cells are the founding cancer
Tam, Wai Leong, Ng, Huck Hui
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SOX2 in development and cancer biology
Seminars in Cancer Biology, 2020 The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that SOX2 positively affects cancer cell traits ...
Daniel, Novak +5 more
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Transcription factor Six2 induces a stem cell‐like phenotype in renal cell carcinoma cells
FEBS Open Bio, 2019 Renal cell carcinoma (RCC) accounts for 2–3% of adult malignant tumors, and the incidence of RCC worldwide has increased by about 2% over the past two decades.
Na Cheng +3 more
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Decreased Sox2 messenger RNA expression in basal cell carcinoma
Indian Journal of Dermatology, 2020 Background: Sox2, zeb1, and p21 have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated.
Reza Ahmadi-Beni +8 more
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