Results 21 to 30 of about 65,805 (290)

SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation

Viruses, 2020
Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII). EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and ...
Hua Yang, Jiayin Mo, Qi Xiang, Peiyi Zhao, Yunting Song, Ge Yang, Kailang Wu, Yingle Liu, Weiyong Liu, Jianguo Wu   +9 more
doaj   +1 more source

Karyopherina 2 knockdown inhibits osteosarcoma cell proliferation and angiogenesis in mice by suppressing Sox2 expression

Di-san junyi daxue xuebao, 2019
Objective To explore the effect of karyopherina 2 (KPNA2) knockdown on osteosarcoma cell proliferation and angiogenesis and the possible molecular mechanism.
GE Qiaofeng, ZHANG Long, SUN Xiaojuan, LYU Zhi   +3 more
doaj   +1 more source

A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling

Biology Open, 2021
The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in in vitro culture.
Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic   +8 more
doaj   +1 more source

Human Papilloma Virus and Cancer Stem Cell markers in Oral Epithelial Dysplasia—An Immunohistochemical Study

Rambam Maimonides Medical Journal, 2021
Objectives: To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human ...
Prasanth Thankappan, Madhavan Nirmal Ramadoss, Tharmasahayam Isaac Joseph, Percy Ida Augustine, Isaacjoseph Bevin Shaga, Jashree Thilak   +5 more
doaj   +1 more source

Decreased Sox2 messenger RNA expression in basal cell carcinoma

Indian Journal of Dermatology, 2020
Background: Sox2, zeb1, and p21 have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated.
Reza Ahmadi-Beni, Fatemeh Vand-Rajabpour, Mohamadreza Ahmadifard, Maryam Daneshpazhooh, Pedram Noormohammadpour, Javad Rahmati, Kambiz Kamyab Hesari, Mehdi Yaseri, Mina Tabrizi   +8 more
doaj   +1 more source

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma [PDF]

Frontiers in Oncology, 2016
Glioblastoma is the most common and malignant brain cancer in adults. Current therapy consisting of surgery followed by radiation and temozolomide has a moderate success rate and the tumor reappears. Among the features that a cancer cell must have to survive the therapeutic treatment and reconstitute the tumor is the ability of self-renewal. Therefore,
Nicolás Samprón, Ander Matheu, J. Undabeitia, Laura Garros-Regulez, Olatz Arrizabalaga, Estefania Carrasco-Garcia, Sergio Torres-Bayona, Larraitz Egaña, Leire Moreno-Cugnon, Aquilino Lantero, Idoia Garcia, Jorge Villanua, Paula Aldaz, Irune Ruiz   +13 more
openaire   +4 more sources

Immunohistochemical investigation of SOX2 expression in Iraqi patients with high-grade glioma [PDF]

Romanian Journal of Neurology
Background. Gliomas, particularly high-grade gliomas, are aggressive brain tumors with poor prognosis. Sex-determining region Y-box 2 (SOX2) is a transcription factor responsible for stem cell maintenance and differentiation and has been implicated in ...
Hadeer Hashim Shams Uldeen, Abed Hassan Barraj, Sameer Hameed Hammadi   +2 more
doaj   +1 more source

Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

eLife, 2020
The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals,
Zhian Ye, Zhongwu Su, Siyu Xie, Yuye Liu, Yongqiang Wang, Xi Xu, Yiqing Zheng, Meng Zhao, Linjia Jiang   +8 more
doaj   +1 more source

The Sox2 transcription factor binds RNA [PDF]

Nature Communications, 2020
AbstractCertain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor critical for maintenance of pluripotency and neurogenesis, has been found associated with several lncRNAs, although it is unknown whether these interactions are direct or via other ...
Zachariah E. Holmes, Desmond J. Hamilton, Taeyoung Hwang, Nicholas V. Parsonnet, John L. Rinn, Deborah S. Wuttke, Robert T. Batey   +6 more
openaire   +4 more sources

Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis

Clocks & Sleep, 2020
Basic helix-loop-helix (BHLH) transcription factors differentiated embryonic chondrocyte gene 1 (DEC1) and gene 2 (DEC2) regulate circadian rhythms, apoptosis, epithelial mesenchymal transition (EMT), invasions and metastases in various kinds of cancer.
Fuyuki Sato, Ujjal K. Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragaki   +5 more
doaj   +1 more source