Results 41 to 50 of about 65,805 (290)
SOX2-Sensing: Insights into the Role of SOX2 in the Generation of Sensory Cell Types in Vertebrates
International Journal of Molecular Sciences, 2023 The SOX2 transcription factor is a key regulator of nervous system development, and its mutation in humans leads to a rare disease characterized by severe eye defects, cognitive defects, hearing defects, abnormalities of the CNS and motor control problems.
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Functional characterization of SOX2 as an anticancer target [PDF]
Signal Transduction and Targeted Therapy, 2020 AbstractSOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal, reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a complicated network at the levels of transcription, post-transcription, and post-translation.
Shizhen Zhang, Xiufang Xiong, Yi Sun
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Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua +4 more
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Biology Open, 2020 In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia
Machiko Teramoto +7 more
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Molecular Oncology, 2021 The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically ...
Abril Marcela Herrera‐Solorio +12 more
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Sox2 Uses Multiple Domains to Associate with Proteins Present in Sox2-Protein Complexes
PLoS ONE, 2010 Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC). These master regulators associate with co-activators and co-repressors to precisely control their gene targets. Recent studies using proteomic analysis have identified a large, diverse group of co-
Jesse L. Cox +4 more
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SOX2 is required for inner ear neurogenesis [PDF]
Scientific Reports, 2017 AbstractNeurons of the cochleovestibular ganglion (CVG) transmit hearing and balance information to the brain. During development, a select population of early otic progenitors express NEUROG1, delaminate from the otocyst, and coalesce to form the neurons that innervate all inner ear sensory regions.
Aleta R. Steevens +3 more
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SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond [PDF]
Oncogene, 2019 Research of the past view years expanded our understanding of the various physiological functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis, reprogramming, and cancer. However, while scientific reports featuring novel and exciting aspects of SOX2-driven biology are published in near weekly routine, investigations in the ...
Thorsten Schaefer, Claudia Lengerke
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Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cells. [PDF]
PLoS ONE, 2014 BACKGROUND: Although Sox2 expression has been found in several types of cancer, it has not yet been used to identify or isolate CSCs in somatic carcinoma.
Xiao-Fang Liu +4 more
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PLOS ONE, 2015 Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit their medical applications. To overcome such a difficulty, direct reprogramming of adult somatic cells into iNSCs was proposed.
Jolanta Zieba +9 more
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