Results 81 to 90 of about 2,372,069 (151)

Specialized Pro-Resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure

, 2019
After myocardial infarction, splenic leukocytes direct biosynthesis of specialized pro-resolving mediators (SPMs) that are essential for the resolution of inflammation and tissue repair.
Halade, Ganesh V., Ganesh V. Halade, Bochra Tourki, Tourki, Bochra   +3 more
core   +1 more source

SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor

Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic.
Alnouri, M., Roquid, K., Bonnavion, R., Heering, J., Wang, S., Mueller, C., Kwon, J., Gurke, R., Cho, H., Offermanns, S., Geisslingerb, G., Guenther, S., Jaeger, Y., Wettschureck, N., Proschak, E.   +14 more
core   +2 more sources

Specialized pro-resolving mediators regulate in vitro human airway epithelial resistance to Aspergillus fumigatus

International audienceCystic fibrosis (CF) is caused by mutations in the CFTR gene resulting in alterations in the immune functions of the airway epithelium, including reduced biosynthesis of the specialized pro-resolving lipid mediators (SPMs ...
Briottet, Maëlle, Urbach, Valérie, Sy, Khadeeja Adam, Vaudin, Marie, Barny, Ellie-Flore, El Moustaphaoui, Mohamed, Botterel, Françoise, Valsecchi, Isabel   +7 more
core   +1 more source

Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation

, 2020
Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis.
Gyeoung Jin Kang, Eun Ji Kim, Chang Hoon Lee   +2 more
core   +1 more source

Specialized pro-resolving mediators and cancer: news and promises from the other side of the moon

Frontiers in Pharmacology
In physiological settings, inflammation is not passively terminated but actively resolved through coordinated endogenous programs. A central component of this response is the biosynthesis of specialized pro-resolving mediators (SPMs), including lipoxins,
V. Gatti, V. Gatti, G. Colella, F. Violante, V. M. Fazio, V. M. Fazio, M. Cioce, M. Cioce   +7 more
doaj   +1 more source

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation [PDF]

, 2012
Unresolved inflammation is associated with several widely occurring diseases such as arthritis, periodontal diseases, cancer, and atherosclerosis.
Recchiuti A, Recchiuti, Antonio, Serhan, Charles, Charles N Serhan, Serhan CN, Charles N. Serhan, Antonio Recchiuti, Antonio eRecchiuti   +7 more
core   +1 more source

Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis

Frontiers in Immunology, 2018
The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host’s immune response against Mycobacterium leprae, the etiological agent of leprosy.
Carlos A. M. Silva, John T. Belisle
doaj   +1 more source

Biosynthesis and analytics of specialized pro-resolving mediators: facts and faults

Journal of Lipid Research
Specialized pro-resolving mediators (SPMs) have been suggested to act as key factors that mediate the resolution of inflammation. With the availability of synthetic standards, pharmacological studies have garnered support for the hypothesis.
Nils Helge Schebb, Hartmut Kühn, Nadja Kampschulte, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Hans-Erik Claesson, Karsten H. Weylandt, Nadine Rohwer, Meike J. Saul, Eugen Proschak, Bernhard Brüne, Ulrike Garscha, Thorsten J. Maier, Paola Patrignani, Miguel A. Gijón, Francisco J. Schopfer, Stacy L. Gelhaus, Michael H. Gelb, Robert C. Murphy, Carsten Skarke, Alan R. Brash, Bruce A. Freeman, Ian A. Blair, Derek W. Gilroy, Gerd Geisslinger, Julien Hanson, Kim Ekroos, Garret A. FitzGerald, Astrid S. Kahnt, Valerie B. O’Donnell, Mohamad Wessam Alnouri, Stefan Offermanns, Dieter Steinhilber   +33 more
doaj   +1 more source

Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?

, 2020
Alzheimer’s disease (AD) is a common neurodegenerative disease and a major contributor to progressive cognitive impairment in an aging society. As the pathophysiology of AD involves chronic neuroinflammation, the resolution of inflammation and the ...
Shuzo Yamamoto, Yumi Takano, Yasuyuki Taki, Yasuko Tatewaki, Keishi Miyazawa, Hisanori Fukunaga, Tatsushi Mutoh   +6 more
core   +1 more source

Toll‐like receptor 7 stimulates production of specialized pro‐resolving lipid mediators and promotes resolution of airway inflammation

EMBO Molecular Medicine, 2013
Although specialized pro‐resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain elusive.
Ourania Koltsida, Sergey Karamnov, Katerina Pyrillou, Thad Vickery, Aikaterini‐Dimitra Chairakaki, Constantin Tamvakopoulos, Paschalis Sideras, Charles N. Serhan, Evangelos Andreakos   +8 more
doaj   +1 more source