Results 61 to 70 of about 2,372,069 (151)

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques [PDF]

, 2016
Chronic unresolved inflammation plays a causal role in the development of advanced atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain unclear.
Kuriakose, George, Dorweiler, Bernhard, Heyer, Eric J., Solomon, Robert, Hellmann, Jason, Spite, Matthew, Connolly, E. Sander, Connolly Jr., E. Sander, Tabas, Ira, Colas, Romain A., Proto, Jonathan D., Jones, David M., Fredman, Gabrielle, Solomon, Robert A.   +13 more
core   +1 more source

Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections

, 2023
During an infection, inflammation mobilizes immune cells to eliminate the pathogen and protect the host. However, inflammation can be detrimental when exacerbated and/or chronic.
Geovana Martelossi-Cebinelli, Rubia Casagrande, Waldiceu A. Verri, Matheus Deroco Veloso da Silva, Fernanda S. Rasquel-Oliveira, Victor Fattori   +5 more
core   +1 more source

Testing specialized pro-resolving mediators on bacteria-derived inflammation in chronic rhinosinusitis [PDF]

, 2023
Background and Hypothesis:Chronic rhinosinusitis (CRS) is defined by chronic tissue inflammation, and prior work in the field implicates activation of the NFκb pathway.
Robinson, Peyton, Ramakrishnan, Vijay, Smith, Laura, Edwards, Taiya   +3 more
core  

Emerging locally delivered antimicrobial and immunomodulatory approaches for the prevention/treatment of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje, Ettore Amerio, Irene Mallor, Conrado Aparicio   +3 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Specialized pro-resolving lipid mediators in endodontics: a narrative review

, 2021
International audienceAbstract Endodontics is the branch of dentistry concerned with the morphology, physiology, and pathology of the human dental pulp and periradicular tissues.
Hosseinpour, Sepanta, Aubeux, Davy, Gaudin, Alexis, Geoffroy, Valérie, Peters, Ove, Pérez, Fabienne, Tessier, Solène   +6 more
core   +1 more source

The role of specialized pro-resolving mediators in skin inflammation

Pifu-xingbing zhenliaoxue zazhi
Specialized pro-resolving mediators (SPMs) are endogenous lipid molecules that are biosynthesized from ω-3/ω-6 polyunsaturated fatty acids via key enzymes such as lipoxygenases and cyclooxygenases.
WANG Yuying, LIN Simin, WANG Xiaoying, WEI Yun, WANG Fuming, XIAO Yue, HUANG Hu, WANG Jing   +7 more
doaj   +1 more source

Calibration‐Free Estimation of Cerebrovascular Reactivity From Resting‐State BOLD fMRI Using Reconstructed Respiratory Fluctuations

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2755-2766, December 2026.
ABSTRACT Purpose Cerebrovascular reactivity (CVR) provides an important index of vascular health and is conventionally quantified using a hypercapnic gas or breath‐hold challenge in conjunction with blood‐oxygen‐level‐dependent functional magnetic resonance imaging (BOLD‐fMRI).
Abdoljalil Addeh, Ethan Church, Muhammad Mahajna, Karen Ardila, Pattarawut Charatpangoon, Alexander D. Cohen, Yang Wang, Rebecca J. Williams, G. Bruce Pike, M. Ethan MacDonald   +9 more
wiley   +1 more source

ZBP1‐mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Metabolic stress increases Alzheimer's disease (AD) risk, but mechanisms linking metabolic dysfunction to neuroimmune dysregulation remain unclear. METHODS We assessed cognition in community‐dwelling participants and used high‐fat diet (HFD)‐fed 5xFAD mice, high glucose and high palmitate (HGHP)‐treated regulatory T cell (Treg) co‐
Shanshan Huang, Zengyu Zhang, Jiajie Xia, Mengqiu Deng, Fangzheng Chen, Meng Wang, Yuchao Fei, Zhiwen Jiang, Chenyu Lu, Jiayu Fu, Jingchun Guo, Houguang Zhou   +11 more
wiley   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source