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Das ernährungstherapeutische Potenzial sogenannter „Specialized Pro-Resolving Mediators (SPMs)“ : eine Literaturübersicht zur Wirksamkeit aus kontrollierten klinischen Studien [PDF]

, 2021
Specialized Pro-Resolving Mediators (SPMs) sind Lipidsignalmoleküle, die aus den Fettsäuren (FS) Eicosapentaensäure (EPA), Docohexaensäuren (DHA), Docosapentaensäuren (DPA) und Arachidonsäure (AA) abgeleitet werden.
Irmak, Can
core  

Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarctionResearch in context

EBioMedicine, 2019
Background: Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM).
Linn E. Fosshaug, Romain A. Colas, Anne K. Anstensrud, Ida Gregersen, Ståle Nymo, Ellen L. Sagen, Annika Michelsen, Leif E. Vinge, Erik Øie, Lars Gullestad, Bente Halvorsen, Trond V. Hansen, Pål Aukrust, Jesmond Dalli, Arne Yndestad   +14 more
doaj   +1 more source

RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis

Frontiers in Immunology, 2021
Periodontitis is a chronic inflammatory disease associated with the formation of dysbiotic plaque biofilms and characterized by the progressive destruction of the alveolar bone.
Carla Alvarez, Henrique Abdalla, Henrique Abdalla, Salwa Suliman, Salwa Suliman, Paola Rojas, Yu-Chiao Wu, Yu-Chiao Wu, Rawan Almarhoumi, Rawan Almarhoumi, Ren-Yeong Huang, Ren-Yeong Huang, Mario Galindo, Mario Galindo, Rolando Vernal, Alpdogan Kantarci, Alpdogan Kantarci   +16 more
doaj   +1 more source

Altered Tissue Specialized Pro-Resolving Mediators in Chronic Rhinosinusitis

, 2021
Current literature implicates arachidonic acid-derived leukotrienes and prostaglandins in the pathogenesis of chronic rhinosinusitis. However, other omega-3 and omega-6 derived lipid mediators, such as specialized pro-resolving mediators (SPMs), may also
Kroehl, Miranda E., Armstrong, Michael, Vickery, Thad W., Reisdorph, Nichole A., Ramakrishnan, Vijay R., Robertson, Charles E., Kofonow, Jennifer M., Frank, Daniel N.   +7 more
core   +1 more source

Harnessing Inflammation Resolution in Arthritis: Current Understanding of Specialized Pro-resolving Lipid Mediators’ Contribution to Arthritis Physiopathology and Future Perspectives

Frontiers in Physiology, 2021
The concept behind the resolution of inflammation has changed in the past decades from a passive to an active process, which reflects in novel avenues to understand and control inflammation-driven diseases.
Tiago H. Zaninelli, Victor Fattori, Waldiceu A. Verri   +2 more
doaj   +1 more source

Protective Potential of Maresins in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases are the leading causes of global mortality. Growing evidence suggests that unresolved inflammation contributes to the chronicity, progression and morbidity of many cardiovascular diseases, thus emphasizing the urgent need to ...
Min Liu, Huixiang He, Lihong Chen
doaj   +1 more source

The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators

Pharmaceuticals, 2021
The resolution of inflammation is an integral part of the acute inflammatory response and eventually leads to the return to homeostasis. It is supported by specialized pro-resolving mediators (SPMs) that act as immunoresolvents via specific G-protein ...
Paul M. Jordan, Emeline van Goethem, Andrea M. Müller, Kathrin Hemmer, Virginie Gavioli, Vincent Baillif, Yvonne Burmeister, Natascha Krömmelbein, Marc Dubourdeau, Bernd Seilheimer, Oliver Werz   +10 more
doaj   +1 more source

Specialized Pro-Resolving Lipid Mediators and Dietary Omega-3/6 Fatty Acids in Selected Inflammatory Skin Diseases: A Systematic Review

Antioxidants
Specialized pro-resolving mediators (SPMs), including lipoxins, resolvins, protectins, and maresins, actively terminate inflammation and restore tissue homeostasis.
Angelika Biełach-Bazyluk, Olivia Jakubowicz-Zalewska, Hanna Myśliwiec, Iwona Flisiak   +3 more
doaj   +1 more source

Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain

Journal of Translational Medicine, 2020
Background Marine lipids contain omega-3 fatty acids that can be metabolized into anti-inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can serve as modulators of the pain experience.
Nini Callan, Doug Hanes, Ryan Bradley
doaj   +1 more source

Unexpected Role of MPO-Oxidized LDLs in Atherosclerosis: In between Inflammation and Its Resolution

Antioxidants, 2022
Inflammation and its resolution are the result of the balance between pro-inflammatory and pro-resolving factors, such as specialized pro-resolving mediators (SPMs).
Cecilia Tangeten, Karim Zouaoui Boudjeltia, Cedric Delporte, Pierre Van Antwerpen, Keziah Korpak   +4 more
doaj   +1 more source