Results 21 to 30 of about 2,372,069 (151)

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far? [PDF]

Frontiers in Pharmacology, 2022
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15 ...
Nils Helge Schebb, Hartmut Kühn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O’Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Stefan Offermanns, Dieter Steinhilber, Dieter Steinhilber   +22 more
doaj   +2 more sources

Advances in the role of specialized pro-resolving mediators in periodontitis [PDF]

Frontiers in Immunology
Periodontitis is a chronic inflammatory disease driven by dysregulated host–microbial interactions and failure of endogenous inflammation resolution, leading to progressive destruction of periodontal tissues.
Huiting Hu, Hongxing Chu, Zhenzhen Wu, Zekun Gan, Yong Yang   +4 more
doaj   +2 more sources

Pro-Resolving Lipid Mediators in the Pathophysiology of Asthma

Medicina, 2019
Asthma is one of the most important medical and social problems of our time due to the prevalence and the complexity of its treatment. Chronic inflammation that is characteristic of asthma is accompanied by bronchial obstruction, which involves various ...
Oxana Kytikova, Tatyana Novgorodtseva, Yulia Denisenko, Marina Antonyuk, Tatyana Gvozdenko   +4 more
doaj   +2 more sources

Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities [PDF]

Frontiers in Immunology, 2021
Inflammation is a fundamental physiological response orchestrated by innate immune cells to restore tissue homeostasis. Specialized pro-resolving mediators (SPMs) are involved in active resolution of inflammation but when inflammation is incomplete ...
Margot Lavy, Vanessa Gauttier, Nicolas Poirier, Sophie Barillé-Nion, Christophe Blanquart   +4 more
doaj   +2 more sources

Resolving Inflammation in CKD: The Potential of SPMs and Omega-3 Derivatives as Biomarkers and Therapeutics [PDF]

Biomedicines
Chronic kidney disease (CKD) affects more than 10% of the population and is associated with a persistent, low-grade inflammatory state that accelerates tubulointerstitial fibrosis, worsens prognosis, and increases cardiovascular risk. This review aims to
Beata Franczyk, Wiktoria Lisińska, Katarzyna Hossa, Kinga Katańska, Anna Wieczorek, Aleksandra Prusak, Zuzanna Biegała, Jacek Rysz, Ewelina Młynarska   +8 more
doaj   +2 more sources

Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids

Biomedicines
Uterine leiomyoma (uterine fibroids, UF) are benign myometrium tumors that affect up to 70% of the female population and may lead to severe clinical symptoms.
Pedro-Antonio Regidor, Manuela Mayr, Fernando Gonzalez Santos, Beatriz Lazcoz Calvo, Rocio Gutierrez, Jose Miguel Rizo   +5 more
doaj   +3 more sources

Roles of specialized pro-resolving mediators and omega-3 polyunsaturated fatty acids in periodontal inflammation and impact on oral microbiota

Frontiers in Oral Health, 2023
Periodontitis is a chronic inflammatory disease induced by dysbiotic dental biofilms. Management of periodontitis is primarily anti-bacterial via mechanical removal of bacterial biofilm.
Chun-Teh Lee, Gena D. Tribble
doaj   +2 more sources

MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E2 [PDF]

Stem Cell Research & Therapy
Background The resolution of inflammation is an active process triggered in the acute phase of inflammation and mainly directed by specialized pro-resolving mediators (SPMs).
Ismael Bermejo-Álvarez, Cristina Vázquez, Alberto Irigaray-Moreno, Ignacio Quevedo-Romero, Aránzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo   +6 more
doaj   +2 more sources

Role and mechanism of specialized pro-resolving mediators in obesity-associated insulin resistance

Lipids in Health and Disease
With the changing times, obesity has become a characteristic epidemic in the context of the current era. Insulin resistance (IR) is most commonly caused by obesity, and IR is a common basis of the pathogenesis of many diseases such as cardiovascular ...
Xinru Liu, Yu Tang, Yuanyuan Luo, Yongxiang Gao, Lisha He   +4 more
doaj   +2 more sources

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis [PDF]

Frontiers in Pharmacology, 2019
Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease.
Antonio Recchiuti, Antonio Recchiuti, Domenico Mattoscio, Domenico Mattoscio, Elisa Isopi, Elisa Isopi   +5 more
doaj   +2 more sources