Results 31 to 40 of about 2,372,069 (151)

Inflammation resolution-based treatment of atherosclerosis using biomimetic nanocarriers loaded with specialized pro-resolving lipid mediators

Materials Today Bio
Recent studies have shown that chronic inflammation in atherosclerotic (ATH) lesions is due to an inability to resolve the inflammatory response. We evaluated the therapeutic potential of specialized pro-resolving mediators (SPMs) incorporated into ...
Maria Anghelache, Geanina Voicu, Ruxandra Anton, Florentina Safciuc, Delia Boteanu, Mariana Deleanu, Mihaela Turtoi, Maya Simionescu, Ileana Manduteanu, Manuela Calin   +9 more
doaj   +3 more sources

Progress of specialized pro-resolving mediators in diabetic kidney disease [PDF]

Jichu yixue yu linchuang, 2023
Specialized pro-resolving mediators (SPMs) can promote the regression of chronic inflammatory response in diabetic kidney disease (DKD), inhibit renal fibrosis and protect renal function by inhibiting renal intrinsic cell inflammatory response ...
LIU Chong, LIU Yingying, GUO Zhaoan
doaj   +1 more source

Pro-Resolving Ligands Orchestrate Phagocytosis

Frontiers in Immunology, 2021
The resolution of inflammation is a tissue protective program that is governed by several factors including specialized pro-resolving mediators (SPMs), proteins, gasses and nucleotides. Pro-resolving mediators activate counterregulatory programs to quell
Christa Decker, Sudeshna Sadhu, Gabrielle Fredman   +2 more
doaj   +1 more source

Specialized Pro-resolving Mediators: Resolving Inflammation and Restoring Bone [PDF]

, 2023
Periodontitis is a chronic inflammatory disease characterized by gingival inflammation and loss of periodontal ligament attachment, which if severe enough can lead to the irreversible destruction of surrounding alveolar bone.
Tran, Amber, Raglin, Amber, Bilbrey, Carrie Nichole   +2 more
core   +1 more source

Role of Specialized Pro-Resolving Mediators in Neuropathic Pain [PDF]

, 2021
Inflammation and neuroinflammation are critical mechanisms in the generation of neuropathic pain that is experienced in several chronic diseases. The aberrant inflammation that triggers this pathophysiologic process can be tracked down to an exacerbated ...
Leuti A., Maccarrone M., Fava M., Pellegrini N.   +3 more
core   +2 more sources

Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved?

Cells, 2023
So far, tendon regeneration has mainly been analyzed independent from its adjacent tissues. However, the subacromial bursa in particular appears to influence the local inflammatory milieu in the shoulder.
Franka Klatte-Schulz, Nicole Bormann, Aysha Bonell, Jasmin Al-Michref, Hoang Le Nguyen, Pascal Klöckner, Kathi Thiele, Philipp Moroder, Martina Seifert, Birgit Sawitzki, Britt Wildemann, Georg N. Duda   +11 more
doaj   +1 more source

A novel therapeutic strategy of obesity from the perspective of SPMs [PDF]

Exploration of Endocrine and Metabolic Diseases
The global prevalence of obesity and type 2 diabetes mellitus (T2DM)—the most common metabolic disorders—has reached epidemic proportions over the past half-century, with obesity being a key driver of insulin resistance and T2DM development.
Ze-Wei Zhao
doaj   +1 more source

Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study

Journal of Translational Medicine, 2023
Background Specialized pro-resolving mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA are recognized as potentially therapeutic in inflammatory diseases because SPMs regulate the inflammation process, which leads to, for example; swelling and ...
Ingrid Möller, Gil Rodas, Jose María Villalón, Jose A. Rodas, Francisco Angulo, Nina Martínez, Josep Vergés   +6 more
doaj   +1 more source

Distinct Profiles of Specialized Pro-Resolving Lipid Mediators and Corresponding Receptor Gene Expression In Periodontal Inflammation [PDF]

, 2020
Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in ...
Zhu, Lisha, Van Dyke, Thomas E, Bokka, Nishantha R, Maddipati, Krishna Rao, Ayilavarapu, Srinivas, Chen, Wanqi, Lee, Chun-Teh, Ferguson, Brittney, Angelov, Nikola, Weltman, Robin, Zheng, W Jim   +10 more
core   +1 more source

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Frontiers in Immunology, 2021
Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury.
Javier Perez-Hernandez, Javier Perez-Hernandez, Valerio Chiurchiù, Valerio Chiurchiù, Sylvain Perruche, Sylvain Perruche, Sylvaine You   +6 more
doaj   +1 more source