Results 51 to 60 of about 2,372,069 (151)
Biotechnology and Bioengineering, EarlyView.A recombinant whole‐cell platform expressing a bacterial 15S‐LOX exhibiting 5S‐LOX activity enabled the stereoselective production of RvE2 and 17R‐RvD5 from 18R‐HEPE and 17R‐HDHA, achieving final concentrations of 0.57 mM and 1.48 mM from 4.0 mM substrates, respectively, under optimized conditions.
Hee‐Gyeong Lee +2 more
wiley +1 more source
Specialized Pro-Resolving Lipid Mediators: New Therapeutic Approaches for Vascular Remodeling [PDF]
, 2022 Vascular remodeling is a typical feature of vascular diseases, such as atherosclerosis, aneurysms or restenosis. Excessive inflammation is a key mechanism underlying vascular remodeling via the modulation of vascular fibrosis, phenotype and function ...
Díaz Del Campo, Lucía Serrano +14 more
core +1 more source
Epileptic Disorders, EarlyView.Abstract Objective Depression is common in mesial temporal lobe epilepsy (mTLE), but its neuroanatomical basis—and overlap with major depressive disorder (MDD)—remains poorly defined. We investigated whether the cortical and subcortical alterations reported in MDD are also present in mTLE and leveraged the frequent occurrence of depression after ...
Philip Fink‐Jensen +9 more
wiley +1 more source
Frontiers in Immunology, 2020 Asthma represents one of the leading chronic diseases worldwide and causes a high global burden of death and disability. In asthmatic patients, the exacerbation and chronification of the inflammatory response are often related to a failure in the ...
Daniella Bianchi Reis Insuela +5 more
doaj +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections [PDF]
, 2021 Acute inflammation caused by bacterial infections is an essential biological defence mechanism of the host in order to neutralize and clear the invaders and to return to homeostasis. Despite its protective function, inflammation may become persistent and
Paul M. Jordan +3 more
core +1 more source
Identifiable regional and neural network abnormalities in early childhood anxiety
JCPP Advances, EarlyView.Abstract Background Although the neural underpinnings of anxiety have been investigated, most research has been confined to adolescence and adulthood, with less of a focus on the early childhood period. Little is known about the role of anticipatory fear processing early childhood, which is a sensitive period for anxiety development.
Khalil I. Thompson +7 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli +6 more
wiley +1 more source
Environmental Stressors Influence Spatial Complexity in a Fluvial Macrophyte meadow
Remote Sensing in Ecology and Conservation, EarlyView.This research investigates the nonlinear relationships between environmental stressors and the fine‐scale spatial complexity of a fluvial macrophytes meadow. The use of multivariate spatial analysis allowed us to identify two major environmental gradients (nutrients and light) and two major complexity gradients (related to abundance and fragmentation).
Arthur de Grandpré +2 more
wiley +1 more source
Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid
, 2023 Docosahexaenoic acid (C22:6n-3, DHA) is the precursor of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families which have been considered therapeutic bioactive compounds for human health.
Rodrigo Valenzuela +3 more
core +1 more source