Results 1 to 10 of about 44,827 (196)

Dietary spermidine improves cognitive function [PDF]

Cell Reports, 2021
Summary: Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood.
Sabrina Schroeder, Sebastian J. Hofer, Andreas Zimmermann, Raimund Pechlaner, Christopher Dammbrueck, Tobias Pendl, G. Mark Marcello, Viktoria Pogatschnigg, Martina Bergmann, Melanie Müller, Verena Gschiel, Selena Ristic, Jelena Tadic, Keiko Iwata, Gesa Richter, Aitak Farzi, Muammer Üçal, Ute Schäfer, Michael Poglitsch, Philipp Royer, Ronald Mekis, Marlene Agreiter, Regine C. Tölle, Péter Sótonyi, Johann Willeit, Barbara Mairhofer, Helga Niederkofler, Irmgard Pallhuber, Gregorio Rungger, Herbert Tilg, Michaela Defrancesco, Josef Marksteiner, Frank Sinner, Christoph Magnes, Thomas R. Pieber, Peter Holzer, Guido Kroemer, Didac Carmona-Gutierrez, Luca Scorrano, Jörn Dengjel, Tobias Madl, Simon Sedej, Stephan J. Sigrist, Bence Rácz, Stefan Kiechl, Tobias Eisenberg, Frank Madeo   +46 more
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Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster [PDF]

Frontiers in Neuroscience
IntroductionThe polyamines putrescine, spermidine, and spermine are ubiquitous metabolites synthesized in all cells. The intracellular levels of polyamines, especially spermidine, decrease in aging.
Florance Parweez, Florance Parweez, Roger Palou, Ruizhen Li, Lanna Kadhim, Heath MacMillan, Mike Tyers, Mike Tyers, X. Johné Liu, X. Johné Liu, X. Johné Liu   +10 more
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Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS [PDF]

Hereditas
Background This study examines the causal relationship between spermidine levels and coronary artery disease (CHD) risk using a bidirectional Mendelian Randomization (MR) approach.
Tianyi Wang, Li Lin, Yaodong Ding, Yang Zhang, Zehao Zhao, Ruixiang Feng, Yingxuan Bai, Zhennan Li, Yuncong Shi, Na Li, Yong Zeng   +10 more
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Free spermidine evokes superoxide radicals that manifest toxicity

eLife, 2022
Spermidine and other polyamines alleviate oxidative stress, yet excess spermidine seems toxic to Escherichia coli unless it is neutralized by SpeG, an enzyme for the spermidine N-acetyl transferase function. Thus, wild-type E.
Vineet Kumar, Rajesh Kumar Mishra, Debarghya Ghose, Arunima Kalita, Pulkit Dhiman, Anand Prakash, Nirja Thakur, Gopa Mitra, Vinod D Chaudhari, Amit Arora, Dipak Dutta   +10 more
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Auranofin accelerates spermidine-induced apoptosis via reactive oxygen species generation and suppression of PI3K/Akt signaling pathway in hepatocellular carcinoma

Fisheries and Aquatic Sciences, 2023
Auranofin is a US Food and Drug Administration (FDA)-approved anti-arthritis medication that functions as a thioredoxin reductase inhibitor. Spermidine, a polyamine present in marine algae, can exert various physiological functions.
Hyun Hwangbo, Da Hye Kim, Min Yeong Kim, Seon Yeong Ji, EunJin Bang, Su Hyun Hong, Yung Hyun Choi, JaeHun Cheong   +7 more
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Spermidine alleviating oxidative stress and apoptosis by inducing autophagy of granulosa cells in Sichuan white geese

Poultry Science, 2023
: Spermidine have been reported a role in antioxidative, antiaging, and antiinflammatory. Oxidative stress causes granulosa cell (GC) apoptosis, follicular atresia, and impairs poultry reproductive functions.
Dongmei Jiang, Xin Wang, Xuemin Zhou, Zelong Wang, Shuo Li, Qian Sun, Yilong Jiang, Chengweng Ji, Weikang Ling, Xiaoguang An, Bo Kang   +10 more
doaj   +1 more source

The effect of spermidine on autoimmunity and beta cell function in NOD mice

Scientific Reports, 2022
Spermidine is a natural polyamine which was shown to prolong lifespan of organisms and to improve cardiac and cognitive function. Spermidine was also reported to reduce inflammation and modulate T-cells. Autophagy is one of the mechanisms that spermidine
Ceren Karacay, Barbara Prietl, Clemens Harer, Barbara Ehall, Christoph W. Haudum, Kaddour Bounab, Joakim Franz, Tobias Eisenberg, Frank Madeo, Dagmar Kolb, Kerstin Hingerl, Markus Hausl, Christoph Magnes, Selma I. Mautner, Petra Kotzbeck, Thomas R. Pieber   +15 more
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Bioengineering of Escherichia coli Nissle 1917 for Production and Excretion of Spermidine, a Key Metabolite in Human Health

Metabolites, 2022
Microbiota-derived metabolites have biological importance for their host. Spermidine, a metabolite described for its protective effect in age-related diseases, is now studied for its role in the resolution of inflammation and gut homeostasis.
Clément Caffaratti, Caroline Plazy, Valérie Cunin, Bertrand Toussaint, Audrey Le Gouellec   +4 more
doaj   +1 more source

Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis

Communications Biology, 2023
Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis.
Seishi Aihara, Kumiko Torisu, Yushi Uchida, Noriyuki Imazu, Toshiaki Nakano, Takanari Kitazono   +5 more
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Effects of Spermidine on Cell Proliferation, Migration, and Inflammatory Response in Porcine Enterocytes

Frontiers in Bioscience-Landmark, 2022
Background: Polyamines have been demonstrated to be beneficial to porcine intestinal development. Our previous study showed that putrescine mitigates intestinal atrophy in weanling piglets and suppresses inflammatory response in porcine intestinal ...
Zi-xi Wei, Long Cai, Xue-mei Zhao, Xian-ren Jiang, Xi-long Li   +4 more
doaj   +1 more source