Results 11 to 20 of about 44,827 (196)

Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study

Frontiers in Nutrition, 2022
The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies.
Liqiang Zheng, Liqiang Zheng, Liqiang Zheng, Yanxia Xie, Zhaoqing Sun, Rui Zhang, Yanan Ma, Yanan Ma, Jiahui Xu, Jiahui Xu, Jia Zheng, Jia Zheng, Qianyi Xu, Qianyi Xu, Zhao Li, Xiaofan Guo, Guozhe Sun, Fuguo Xing, Yingxian Sun, Deliang Wen   +19 more
doaj   +1 more source

Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus

Open Life Sciences, 2021
Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei, Mo Guilin, Jiang Yilong, Kang Bo   +3 more
doaj   +1 more source

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Frontiers in Chemistry, 2023
Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties.
Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Sachin Kumar Singh, Monica Gulati, Monica Gulati, Dinesh Kumar Chellappan, Rashi Rajput, Rashi Rajput, Gaurav Gupta, Gaurav Gupta, Alibek Ydyrys, Marzhan Kulbayeva, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Javad Sharifi-Rad, Kamal Dua, Kamal Dua   +19 more
doaj   +1 more source

Spermidine Promotes Cardioprotective Autophagy [PDF]

Circulation Research, 2017
A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses aging-associated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.
Dan, Tong, Joseph A, Hill
openaire   +2 more sources

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]

PLoS ONE, 2014
Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi   +8 more
doaj   +1 more source

Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
Pseudomonas aeruginosa is a vital opportunistic human bacterial pathogen that causes acute and chronic infections. In this study, we set to determine whether the endogenous spermidine biosynthesis plays a role in regulation of type III secretion system ...
Qiqi Lin, Huishan Wang, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Guohui Yu, Zeling Xu, Ping Cheng, Zhibin Liang, Lian-Hui Zhang   +9 more
doaj   +1 more source

Alleviation of low-irrigation effects on chickpea (Cicer arietinum L.) using spermidine [PDF]

پژوهش‌های حبوبات ایران, 2020
IntroductionChickpea is one of the pulse crops and its protein percent is about 22 to 24 percent. Therefore it plays an important nutritional role in human being diet.
Vahid Sharifi, Manouchehr Gholipoor, Hamid Abbasdokht   +2 more
doaj   +1 more source

Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Gut Microbes, 2020
Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction ...
Lingyan Ma, Yinhua Ni, Zhe Wang, Wenqing Tu, Liyang Ni, Fen Zhuge, Aqian Zheng, Luting Hu, Yufeng Zhao, Liujie Zheng, Zhengwei Fu   +10 more
doaj   +1 more source

Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults

Biomedicines, 2023
Early diagnosis and therapeutic intervention improve the quality of life and prognosis of patients with sarcopenia. The natural polyamines spermine and spermidine are involved in many physiological activities.
Hidenori Sanayama, Kiyonori Ito, Susumu Ookawara, Takeshi Uemura, Yoshio Sakiyama, Hitoshi Sugawara, Kaoru Tabei, Kazuei Igarashi, Kuniyasu Soda   +8 more
doaj   +1 more source

The Protective Effect of Topical Spermidine on Dry Eye Disease with Retinal Damage Induced by Diesel Particulate Matter2.5

Pharmaceutics, 2021
Air pollutants, especially ambient fine particulate matter2.5, may contribute to various ocular surface disorders, including dry eye disease, keratitis and conjunctivitis.
Hyesook Lee, Da Hye Kim, Hyun Hwangbo, So Young Kim, Seon Yeong Ji, Min Yeong Kim, Jung-Hyun Shim, Sun-Hee Leem, Jin Won Hyun, Gi-Young Kim, Yung Hyun Choi   +10 more
doaj   +1 more source