Metabolites, 2022 Microbiota-derived metabolites have biological importance for their host. Spermidine, a metabolite described for its protective effect in age-related diseases, is now studied for its role in the resolution of inflammation and gut homeostasis.
Clément Caffaratti +4 more
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Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis
Communications Biology, 2023 Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis.
Seishi Aihara +5 more
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Frontiers in Bioscience-Landmark, 2022 Background: Polyamines have been demonstrated to be beneficial to porcine intestinal development. Our previous study showed that putrescine mitigates intestinal atrophy in weanling piglets and suppresses inflammatory response in porcine intestinal ...
Zi-xi Wei +4 more
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Lifespan-Extending Endogenous Metabolites. [PDF]
Aging CellEndogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Jiang Y, Han JJ.
europepmc +2 more sources
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006 [PDF]
, 2011 Agostinelli, Messenger, Morgan, Pegg
core +2 more sources
Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study
Frontiers in Nutrition, 2022 The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies.
Liqiang Zheng +19 more
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Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
Open Life Sciences, 2021 Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei +3 more
doaj +1 more source
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial [PDF]
, 2019 Background: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues.
Benson, Gloria +18 more
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Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]
PLoS ONE, 2014 Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi +8 more
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Frontiers in Chemistry, 2023 Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties.
Parteek Prasher +19 more
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