Results 81 to 90 of about 44,827 (196)

Quantitative Spermidine Detection in Cosmetics using an Organic Transistor‐Based Chemical Sensor

ChemistryOpen
Spermidine is an essential biomarker related to antiaging. Although the detection of spermidine levels is in high demand in life science fields, easy‐to‐use analytical tools without sample purification have not yet been fully established.
Dr. Yui Sasaki, Kohei Ohshiro, Miyuki Kato, Hikaru Tanaka, Akari Yamagami, Dr. Kazutake Hagiya, Prof. Dr. Tsuyoshi Minami   +6 more
doaj   +1 more source

Age‐related differences in mRNA vaccine immunogenicity and adjuvancy

Immunology &Cell Biology, EarlyView.
Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni, Gemma S Trollope, Patrick Leung, Jonathan L McQualter, Chee Wah Tan, Linfa Wang, Leonard Lim, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, Hareth A Al‐Wassiti, Colin W Pouton, Kylie M Quinn   +12 more
wiley   +1 more source

Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Experimental and Molecular Medicine, 2018
Aging: toward a natural treatment for osteoarthritis The naturally occurring small molecule spermidine might prevent and repair the cartilage damage in osteoarthritis, commonly associated with aging.
Pradeep K. Sacitharan, Seint Lwin, George Bou Gharios, James R. Edwards   +3 more
doaj   +1 more source

Metacaspases contribute to the cellular response to heat stress in a marine diatom

New Phytologist, EarlyView.
Summary Climate‐driven marine heatwaves (HW) are extreme, large‐scale events characterized by elevated ocean temperatures lasting from days to months. Despite their importance, little is known about the molecular mechanisms of algal response to marine HW. Recent studies suggest that metacaspases play an important role in thermotolerance.
Mai Sadeh, Daniella Schatz, Shifra Ben‐Dor, Avia Mizrachi, Shiri Graff van Creveld, Amichai Zafrin, Assaf Vardi   +6 more
wiley   +1 more source

Haploid Mutation Mapping Identifies a Homoeologous Non‐Reciprocal Translocation Linked to Reduced Fibre and Enhanced Protein in Brassica napus

Plant Biotechnology Journal, EarlyView.
ABSTRACT A key challenge for the genetic improvement of canola (Brassica napus), one of the world's most important oilseeds, is the limited natural variation for commercially important traits. The creation of new variation is hindered by the lack of functional knowledge about genes controlling these traits.
Morgan W. Kirzinger, Sarika Saini, Andrea T. Todd, Ushan Alahakoon, Kevin C. Koh, Justin B. Nichol, HaiYing Yuan, Kevin Fengler, Victor Llaca, Dustin Cram, Sampath Perumal, Wali Soomro, Magda Konopka, Tancey Melchkart, Venkat Bandi, Yasmina Bekkaoui, Yifang Tan, Chad Matsalla, Andrew G. Sharpe, Carl Gutwin, Fred Thoonen, Igor Falak, Chad Koscielny, Stuart Gardner, Isobel A. P. Parkin, Marcus A. Samuel, Alison M. R. Ferrie, Dave Charne, Daoquan Xiang, Jetty S. S. AmmiRaju, Sateesh Kagale   +30 more
wiley   +1 more source

The MdICE1/MdFAMA‐MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple

Plant Biotechnology Journal, EarlyView.
ABSTRACT Low temperature is a critical abiotic stress that imposes major constraints on the sustainable development of the fruit tree industry. Although exogenous dopamine has been shown to enhance cold tolerance in plants, its molecular mechanisms in apple (Malus domestica) remain poorly understood.
Kexin Tan, Xinyang Song, Ziyi Xu, Hongzhen Zhu, Ying Zhang, Shuhan Xu, Zhijun Zhang, Pengmin Li, Fengwang Ma, Chao Li   +9 more
wiley   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, EarlyView.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Natural Variations in the Activity of Hydroxycinnamoyl Transferases Promote Accumulation of Metabolites Conferring Rice Resistance

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant‐derived secondary metabolites act as regulators of in planta defence. Plant phenylpropanoid metabolic compounds, including final metabolites such as lignin and flavonoids, and a few intermediate metabolites play critical roles in defence.
Dan Chen, Jiyun Liu, Guixin Yuan, Yingshuang Liu, Wenqian Zhu, Ying Chen, Junyou Geng, Jing Fan, Xiaojing Dong, Meng Yuan   +9 more
wiley   +1 more source

Methyl Jasmonate Seed Priming Mitigates the Defence‐Growth Trade‐Off and Tailors Plant Response to Specific Pests

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo, Adrian Sabater‐Gabriel, Alejandro Garcia, Marta Marina Perez‐Alonso, Rayko Halitschke, M. Estrella Santamaria   +5 more
wiley   +1 more source

Skeletal muscle myosin heavy chain fragmentation following exercise may be linked to post‐exercise inflammation and remodelling

Experimental Physiology, EarlyView.
Abstract The purpose of this exploratory investigation was to determine if acute post‐exercise skeletal muscle myosin heavy chain fragmentation (MyHCfrag) coincides with alterations in molecular chaperones and proteolytic enzymes, select markers of mammalian target of rapamycin complex 1 (mTORC1) signalling, and/or specific gene expression signatures ...
Dakota R. Tiede, Diego Bittencourt, J. Max Michel, Daniel L. Plotkin, Madison L. Mattingly, Derick A. Anglin, Christopher G. Vann, Zachary A. Graham, Timothy J. Broderick, Marcas M. Bamman, Michael D. Roberts   +10 more
wiley   +1 more source