Results 171 to 180 of about 9,200 (222)
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Characterization of Sphinganine Kinase Activity in Corn Shoot Microsomes
Archives of Biochemistry and Biophysics, 1997The activity of sphinganine kinase, the enzyme catalyzing the first step in the breakdown of the sphingoid long-chain base sphinganine by converting it to sphinganine 1-phosphate, was characterized in microsomes isolated from corn shoots. Activity was assayed by monitoring the conversion of [3H]sphinganine to [3H]sphinganine 1-phosphate, which was ...
Gregory J Crowther
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The enzymatic phosphorylation of sphinganine
Biochemical and Biophysical Research Communications, 1969Abstract A partially purified enzyme preparation from bovine kidney has been shown to catalyze the phosphorylation of sphinganine. The enzyme utilizes ATP as a phosphate donor and the product of the reaction has been identified as sphinganine-1-phosphate.
R W, Keenan, B, Haegelin
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Approaches to the preparation of sphinganines
Tetrahedron, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Amy R. Howell +2 more
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Inhibition of microbial adherence by sphinganine
Canadian Journal of Microbiology, 1992Sphingosines (precursors and degeneration products of complex sphingolipids) are mediators in membrane second-messenger cascades and in a wide variety of functions in eukaryotic cells. Sphingosines are also lethal for gram-positive microorganisms. In addition to its direct effect, sphinganine is here reported to affect the adherence of Streptococcus ...
D J, Bibel, R, Aly, H R, Shinefield
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Chemico-Biological Interactions, 2006
Sphinganine concentration (Sa) and sphinganine to sphingosine ratio (Sa/So) are sensitive biomarkers of fumonisin B1 (FB1) exposure in animals and have been proposed to reveal FB1 exposure in humans. They correlate with liver and kidney toxicity and often precede signs of toxicity.
Tran, Stéphane +7 more
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Sphinganine concentration (Sa) and sphinganine to sphingosine ratio (Sa/So) are sensitive biomarkers of fumonisin B1 (FB1) exposure in animals and have been proposed to reveal FB1 exposure in humans. They correlate with liver and kidney toxicity and often precede signs of toxicity.
Tran, Stéphane +7 more
exaly +4 more sources
Synthesis of threo-4,5-dihydroxy diastereomers of sphinganine
Chemistry and Physics of Lipids, 1975The threo-4,5-dihydroxy diastereomers of sphinganine were prepared by the following sequence of reactions: (a) benzoylation of sphingenine to the tribenzoyl derivative; (b) osmylation followed by resolution of the mixture of threo-4,5-dihydroxy tribenzoyl (DHTBS) diastereomers; and (c) alkaline hydrolysis to yield the threo-4,5-dihydroxysphinganines ...
B, Weiss, R L, Stiller
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Chemico-Biological Interactions, 2006
Sa and the Sa/So ratio are very sensitive biomarkers of exposure to fumonisins in several species. We previously demonstrated that increases in Sa and in the Sa/So ratio in serum were less pronounced when ducks ingested fumonisins for more than 7 weeks than when animals were exposed for only 1-2 weeks [S.T. Tran, D. Tardieu, A. Auvergne, J.D. Bailly, R.
Tardieu, Delphine +6 more
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Sa and the Sa/So ratio are very sensitive biomarkers of exposure to fumonisins in several species. We previously demonstrated that increases in Sa and in the Sa/So ratio in serum were less pronounced when ducks ingested fumonisins for more than 7 weeks than when animals were exposed for only 1-2 weeks [S.T. Tran, D. Tardieu, A. Auvergne, J.D. Bailly, R.
Tardieu, Delphine +6 more
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Tissue sphinganine as a biomarker of fumonisin-induced apoptosis
Food Additives and Contaminants, 2001NCTR measured sphinganine concentrations in the livers of mice and in the livers and kidneys of rats in conjunction with a tumour bioassay. In our model of the tumour incidence, target-tissue levels of sphinganine serve as a biomarker for a dose response of fumonisin B1 on cell death.
R R, Delongchamp, J F, Young
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Asymmetric Synthesis of Sphinganine and Clavaminol H
The Journal of Organic Chemistry, 2010An efficient enantioselective synthesis of sphinganine and clavaminol H is reported. These sphingoid-type bases were obtained from commercially available fatty acids using highly enantioselective Ru-catalyzed hydrogenation and organocatalytic electrophilic amination reactions to create the stereogenic centers.
Ramzi Ait-Youcef +2 more
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Synthesis of Fluorinated Sphinganine and Dihydroceramide Analogues
European Journal of Organic Chemistry, 2000With the aim of uncovering inhibitors of dihydroceramide desaturase and ceramide synthase and studying their substrate specificity, the synthesis of short-chain 3-fluorosphinganine and 3-fluorodihydroceramide analogues was effected. The synthesis starts from the known alkynols 1 and 10, respectively, and from the Garner aldehyde 15. The key step is the
Steven De Jonghe +6 more
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