Results 191 to 200 of about 9,200 (222)

Monolayer studies on derivatives of sphinganine and 4t-sphingenine

Chemistry and Physics of Lipids, 1974
Abstract The pressure-area isotherms (π-A-isotherms) at temperatures between 4° and 47°C of the following derivatives of sphinganine and 4 t -sphingenine have been determined. N-palmitoyl-D,L-sphingenine (I), N-palmitoyl-diacetyl-D,L-sphingenine (II), N-acetyl-sphingenine (III), N-acetyl-D,L-erythro-sphinganine (IV), N-acetyl-D,L-threo-sphinganine ...
W. Stoffel, H.D. Pruss, G. Sticht
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ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF D‐THREO‐SPHINGANINE

Chemischer Informationsdienst, 1974
AbstractL‐Serin (I) liefert die Phthaloylverbindung (IIa), die über das Säurechlorid (IIb) in das Diazoketon (III) übergeführt wird.
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Abstract B102: Fenretinide induces lethal autophagy via a novel ensemble of life and death regulators: dihydroceramide and sphinganine versus sphinganine 1-phosphate

Cancer Prevention Research, 2008
Abstract B102 Fenretinide (4-hydroxyphenylretinamide, 4HPR) is a promising anticancer agent that is being evaluated in human clinical trials. One of the proposed mechanisms of action for 4HPR is to increase the biosynthesis of ceramide, an inducer of apoptosis.
Kacee Sims, Katie Fluke, Holly Symolon, Wenjing Zheng, Elizabeth Munter, Amin Momin, Carrie Pack, Chris Haynes, Samuel Kelly, Jeremy Allegood, Elaine Wang, Alfred Merrill   +11 more
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ChemInform Abstract: SYNTH. VON RACEMISCHEM 3‐DEHYDRO‐N‐BENZOYL‐SPHINGANIN

Chemischer Informationsdienst, 1973
AbstractDie Hydroxymethylierung des Benzamidoheptadecanons (I) mit Formalin in Gegenwart von NaHCO3 in Äthanol‐Chloroform bei 38°C liefert das racemische Dehydrobenzoylsphinganin (II), eine biosynthetische Vorstufe der Sphingosin‐ Basen.
N. A. SOKOLOVA, B. I. MITSNER, E. N. ZVONKOVA, R. P. EVSTIGNEEVA   +3 more
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Diastereoselective synthesis of D-threo-sphinganine, L-erythro-sphinganine and (−)-spisulosine through asymmetric α-hydroxylation of a higher homologue of Garner's aldehyde

Tetrahedron, 2017
A diastereoselective route to the synthesis of D-threo-sphinganine, L-erythro-sphinganine and (−)-spisulosine from the higher homologue of Garner's aldehyde prepared from l-aspartic acid is reported. While the starting material contains one of the stereocenters in the target molecules, the other is generated by proline-catalyzed asymmetric α ...
Vipin Kumar Jain, Ramesh Ramapanicker
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Synthesis of tritium labelled phosphonate analogues of sphinganine-1-phosphate

Journal of Labelled Compounds and Radiopharmaceuticals, 1997
Tritiated phosphonate analogues 2 and 10 are prepared as analogues of sphinganine-1-phosphate 4. The key step in this synthesis is the catalytic tritiation of the triple bond in reduction of the protected diethyl-3-(S)-tert-butoxycarbonylamino-4-hydroxy-5-tridecinyl-1-phosphonate by means of sodium boro[ 3 H]hydride as tritium source.
Andreas Schick, Günter Schwarzmann, Thomas Kolter, Konrad Sandhoff   +3 more
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Sphinganine and sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks.

2007
Fumonisin B1 is structurally similar to sphinganine (Sa) and sphingosine (So) and inhibits ceramide synthase. It causes an elevation in Sa concentration, leading to an increase in Sa/So ratio in exposed animals. This increase often precedes fumonisins associated toxicity and that is why Sa/So ratio and free Sa have been proposed as biomarkers of ...
Bailly, J.D., Tardieu, Delphine, Auvergne, Alain, Babile, René, Guerre, P.   +4 more
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Synthesis of sphinganine analogues modified in the head group

Tetrahedron, 1994
Abstract The synthesis of sphinganine analogues modified in the head group is reported. The target compounds are efficiently prepared by means of the Henry reaction. Synthesis and results of preliminary investigations of the derivatives as potential inhibitors of sphingolipid biosynthesis are presented.
Thomas Kolter, Gerhild van Echten-Deckert, Konrad Sandhoff   +2 more
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ChemInform Abstract: Synthesis of Phosphoramide Analogues of Sphinganine‐1‐phosphate.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. SCHICK, T. KOLTER, A. GIANNIS, K. SANDHOFF   +3 more
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ChemInform Abstract: Iodocyclofunctionalization of (Z)‐1‐Trichloroacetimidoyloxyalk‐2‐enes and 3‐Trichloroacetimidoyloxyalk‐1‐enes. Synthesis of (±)‐erythro‐Sphinganine Triacetate and (±)‐threo‐Sphinganine Triacetate.

Chemischer Informationsdienst, 1986
AbstractThe trichloroacetimidate (V) ‐ obtained from the protected propynol (I) ‐ undergoes iodocyclization to give the dihydrooxazole (VI).
A. BONGINI, G. CARDILLO, M. ORENA, S. SANDRI, C. TOMASINI   +4 more
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