Results 11 to 20 of about 9,343 (242)

Trifunctional Sphinganine: A New Tool to Dissect Sphingolipid Function [PDF]

ACS Chemical Biology, 2023
ABSTRACTFunctions of the sphingolipids sphingosine and sphinganine in cells are not well established. While some signaling roles for sphingosine have been elucidated, the closely related sphinganine has been described only insofar as it does not elicit many of the same signaling responses.
Scotland Farley, Frank Stein, Per Haberkant, Fikadu Tafesse, Carsten Schultz   +4 more
openalex   +3 more sources

Blood 1-Deoxysphingolipid Levels Are Associated With Epidermal Denervation in Small Fiber Neuropathy. [PDF]

J Peripher Nerv Syst
ABSTRACT Background and Aims Dysfunctional sphingolipid metabolism leads to nerve fiber degeneration, particularly of small caliber Aδ and C fibers, in hereditary sensory and autonomic neuropathies. We aimed to investigate the association of blood 1‐deoxysphingolipid (1‐deoxySL) profiles and skin denervation in idiopathic small fiber neuropathy (SFN ...
Kreß L, Meyer Zu Altenschildesche C, Egenolf N, Sommer C, Hornemann T, Üçeyler N.   +5 more
europepmc   +2 more sources

Acupuncture for Major Depressive Disorder: Exploring the Gut Microbiota as a Novel Therapeutic Pathway. [PDF]

Brain Behav
Acupuncture at GV20 and ST36 alleviates depression by modulating gut microbiota, increasing beneficial bacteria, and enhancing neuroactive metabolites like Sphinganine 1‐phosphate, thereby restoring neuronal activity and reducing depressive behaviors. ABSTRACT Aims This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36 ...
Wei C, Li Y, Tian J, Lei P, Ding Y, Lu W, He X, Yang Y, Zhu H, Liu R.   +9 more
europepmc   +2 more sources

Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis

Frontiers in Immunology, 2023
IntroductionSepsis is intricately linked to intestinal damage and barrier dysfunction. At present times, there is a growing interest in a metabolite-based therapy for multiple diseases.MethodsSerum samples from septic patients and healthy individuals ...
Zetian Wang, Yue Qi, Fei Wang, Baiyin Zhang, Tang Jianguo   +4 more
doaj   +1 more source

Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P

Microbiology Spectrum, 2022
Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host.
Dev K. Ranjit, Zachary D. Moye, Fernanda G. Rocha, Gregory Ottenberg, Frank C. Nichols, Hey-Min Kim, Alejandro R. Walker, Frank C. Gibson, Mary E. Davey   +8 more
doaj   +1 more source

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Toxins, 2021
Fumonisins (FB) are mycotoxins known to exert most of their toxicity by blocking ceramide synthase, resulting in disruption of sphingolipid metabolism.
Didier Tardieu, Maria Matard-Mann, Pi Nyvall Collén, Philippe Guerre   +3 more
doaj   +1 more source

Nonselective inhibition of neutrophil functions by sphinganine.

Journal of Biological Chemistry, 1987
Sphinganine has been proposed to be a specific inhibitor of protein kinase C. In the present study we have evaluated whether sphinganine is a convenient tool to probe for the role of protein kinase C in neutrophil function. Human neutrophils were loaded with the fluorescent probe quin2 and then tested in parallel for cytosolic free Ca2+, [Ca2+]i ...
Didier Pittet, Kathleen H. Krause, Claes B. Wollheim, Roberto Bruzzone, Daniel P. Lew   +4 more
openalex   +5 more sources

Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs

Toxins, 2020
Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance.
Zhong-Xing Rao, Mike D. Tokach, Jason C. Woodworth, Joel M. DeRouchey, Robert D. Goodband, Hilda I. Calderón, Steve S. Dritz   +6 more
doaj   +1 more source

Phospholipid Interconversion and Transport Are Altered in Glaucoma. [PDF]

FASEB J
Decreased phosphatidylserine (PS) and increased phosphatidylethanolamine (PE) occur in both trabecular meshwork (TM) cells and aqueous humor due to aberrant phosphatidylserine decarboxylase (PSD) over‐expression, and variation in levels of individual PS or PE species differing by only a few acyl chains occurs due to impaired lipid transport due to ...
Edwards G, Kaur R, Mueller A, Ziebarth N, Lee RK, Bhattacharya SK.   +5 more
europepmc   +2 more sources

Serum Sphingolipids Aiding the Diagnosis of Adult HIV-Negative Patients with Talaromyces marneffei Infection

Frontiers in Cellular and Infection Microbiology, 2021
Increasing attention has been directed to Talaromyces marneffei (T. marneffei) infection in HIV-negative patients due to its high mortality rate. However, nonspecific symptoms and biological characteristics similar to those of other common pathogenic ...
Zheng-Tu Li, Lee-Fong Yau, Ye Qiu, Shao-Qiang Li, Yang-Qing Zhan, Wai-Him Chan, Zhao-Ming Chen, Zhun Li, Yongming Li, Ye Lin, Jing Cheng, Jian-Quan Zhang, Zhi-Hong Jiang, Jing-Rong Wang, Feng Ye   +14 more
doaj   +1 more source