Results 21 to 30 of about 9,343 (242)

Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis. [PDF]

J Cell Mol Med
ABSTRACT To investigate the potential bidirectional causal relationship between specific blood metabolites and chronic periodontitis using Mendelian randomisation (MR). A two‐sample bidirectional MR analysis was conducted. Data on 1400 blood metabolites were obtained from a genome‐wide association study involving 8299 participants.
Cai W, Zhao H, Wang P, Chen X, Yang Y, Wu H, Chen Z, Fang F, Qiu W.   +8 more
europepmc   +2 more sources

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]

, 2019
Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra, Piomelli, Daniele, Realini, Natalia, Vozella, Valentina   +3 more
core   +1 more source

The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]

, 2012
Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula, Cossalter, Anne-Marie, Grenier, Bertrand, Kolf-Clauw, Martine, Moll, Wulf-Dieter, Oswald, Isabelle P, Schatzmayr, Gerd, Schwartz, Heidi-Elisabeth, Trumel, Catherine   +8 more
core   +2 more sources

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]

, 2015
Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C, Baulies, A, Caballeria, J, Casas, J, Elena, M, Fabriàs, G, Fernandez-Checa, JC, García-Ruiz, C, Martinez Gili, L, Torres, S   +9 more
core   +2 more sources

Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor [PDF]

Asian Pacific Journal of Cancer Prevention
Cancer cells exhibit selective metabolic reprogramming to promote proliferation, invasiveness, and metastasis. Sphingolipids such as sphingosine and sphinganine have been reported to modulate cell death processes in cancer cells. However, the potential of extracellular sphinganine and its mimetic compounds as inducers of cancer cell death has not been ...
Raskia Nandangiri, T. N. Seethamma, Ajay Kumar, Kiran Bharat Lokhande, Kratika Khunteta, Ameya Hebale, Haet Kothari, Vaidehi Patel, Sachin C. Sarode, Nilesh Kumar Sharma   +9 more
openalex   +3 more sources

Gas-liquid chromatography-mass spectrometry of synthetic ceramides

Journal of Lipid Research, 1969
Two series of ceramides with either sphingosine (sphing-4-enine) or sphinganine as base and with one of the saturated fatty acids C16, C18, C20, C22, C24, C26, or oleic acid were analyzed as the 1,3-di-O-trimethylsilyl ether derivatives by gas ...
Bengt Samuelsson, Karin Samuelsson
doaj   +1 more source

Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria

Frontiers in Microbiology, 2022
Serine palmitoyltransferase (SPT) catalyzes the first and committed step in sphingolipid biosynthesis condensating L-serine and acyl-CoA to form 3-oxo-sphinganine. Whenever the structural gene for SPT is present in genomes of Rhodobacteria (α-, β-, and γ-
Jonathan Padilla-Gómez, Roberto Jhonatan Olea-Ozuna, Sandra Contreras-Martínez, Orlando Morales-Tarré, Daniela A. García-Soriano, Diana X. Sahonero-Canavesi, Sebastian Poggio, Sergio Encarnación-Guevara, Isabel M. López-Lara, Otto Geiger   +9 more
doaj   +1 more source

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

Reactive oxygen species as transducers of sphinganine-mediated cell death pathway [PDF]

Plant Signaling & Behavior, 2011
Long chain bases or sphingoid bases are building blocks of complex sphingolipids that display a signaling role in programmed cell death in plants. So far, the type of programmed cell death in which these signaling lipids have been demonstrated to participate is the cell death that occurs in plant immunity, known as the hypersensitive response.
Mariana Saucedo‐García, Ariadna González‐Solís, Priscila Rodríguez-Mejía, Teresa de Jesús Olivera-Flores, Sonia Vázquez‐Santana, Edgar B. Cahoon, Marina Gavilanes‐Ruíz   +6 more
openalex   +3 more sources

Biosynthesis of sphinganine-analog mycotoxins

Journal of Industrial Microbiology & Biotechnology, 2008
Sphinganine-analog mycotoxins (SAMT) are polyketide-derived natural products produced by a number of plant pathogenic fungi and are among the most economically important mycotoxins. The toxins are structurally similar to sphinganine, a key intermediate in the biosynthesis of ceramides and sphingolipids, and competitive inhibitors for ceramide synthase.
L, Du, X, Zhu, R, Gerber, J, Huffman, L, Lou, J, Jorgenson, F, Yu, K, Zaleta-Rivera, Q, Wang   +8 more
openaire   +2 more sources