Results 71 to 80 of about 9,343 (242)

Rabbit muscle gangliosides

Journal of Lipid Research, 1972
Four ganglioside fractions were isolated from rabbit muscle : one hematoside and three hexosamine-containing species. They were analyzed for hexoses, hexosamine, sialic acid, fatty acids, and long-chain base content.
F.E. Lassaga, I. Albarracin de Lassaga, R. Caputto   +2 more
doaj   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. [PDF]

, 2020
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent ...
Cheung, Andrea L, Cowman, Alan F, Egan, Timothy J, Fidock, David A, Gnädig, Nina F, Goldgof, Gregory M, Huang, Jianbo, Hutson, Dylan, Johnson, Trevor, Kumar, Prianka, LaMonte, Gregory M, Lee, Marcus CS, Luth, Madeline R, Marapana, Danushka S, Mohunlal, Roxanne, Ottilie, Sabine, Rocamora, Frances, Santha Kumar, TR, Siegel, Dionicio, Thompson, Jennifer K, Vigil, Edgar, Williams, Roy M, Winzeler, Elizabeth A, Worgall, Tilla S, Yang, Jennifer, Zou, Bing Yu   +25 more
core   +5 more sources

Fenretinide induces lethal autophagy via a novel ensemble of life and death regulators: dihydroceramide and sphinganine versus sphinganine 1‐phosphate.

The FASEB Journal, 2007
Fenretinide (4‐hydroxyphenylretinamide, 4HPR) is a promising anticancer agent that is being evaluated in human clinical trials. One of the proposed mechanisms of action for fenretinide is to increase the biosynthesis of ceramide, an inducer of apoptosis. Using LC ESI MS/MS for “sphingolipidomic” analysis of MCF7 cells, we find that fenretinide elevates
Kacee Sims, Katie Fluke, Holly Symolon, Wenjing Zheng, Elizabeth Munter, Amin Momin, Carrie Pack, Chris Haynes, Samuel Kelly, Jeremy Allegood, Elaine Wang, Alfred H Merrill   +11 more
openaire   +1 more source

HEPES in Cell Culture Alters the Multi‐Omics Profile Exhibited by Gaucher Disease Fibroblasts

Journal of Cellular Biochemistry, Volume 127, Issue 1, January 2026.
ABSTRACT Lysosomal function can be affected by components in cell culture. This in turn may influence cellular metabolism and, consequently, research and diagnostics outcomes. One such component is the commonly used pH buffer 4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acid (HEPES).
Eleonore M. Corazolla, Bauke V. Schomakers, Maria M. Trętowicz, Jill Hermans, Michel van Weeghel, Frédéric M. Vaz, Mia L. Pras‐Raves, Karen Ghauharali‐van der Vlugt, Femke S. Beers‐Stet, Susanna M. I. Goorden, Judith Jansen‐Meijer, Georges E. Janssens, Carla E. M. Hollak, Riekelt H. Houtkooper, André B. P. van Kuilenburg   +14 more
wiley   +1 more source

Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS

Lipids in Health and Disease, 2023
Background Stroke is the leading cause of death in humans worldwide, and its incidence increases every year. It is well documented that lipids are closely related to stroke.
Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie, Yingfeng Zhang   +4 more
doaj   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction

Journal of Lipid Research, 2015
Ceramides are synthesized by six mammalian ceramide synthases (CerSs), each of which uses fatty acyl-CoAs of different chain lengths for N-acylation of the sphingoid long-chain base. We now describe a rapid and reliable CerS assay that uses a fluorescent
Rotem Tidhar, Kacee Sims, Eden Rosenfeld-Gur, Walter Shaw, Anthony H. Futerman   +4 more
doaj   +1 more source

Serum metabolite profiling reveals metabolic characteristics of sepsis patients using LC/MS-based metabolic profiles: a cross-sectional study

BMC Medical Genomics, 2023
Background Individuals with sepsis exhibited a higher likelihood of benefiting from early initiation of specialized treatment to enhance the prognosis of the condition. The objective of this study is to identify potential biomarkers of sepsis by means of
Jinliang Peng, Chongrong Qiu, Jun Zhang, Xiaoliu Xiao   +3 more
doaj   +1 more source

Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells [PDF]

, 2014
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form.
Lee, WJ, Lee, YM, Lim, JS, Oh, S, Suh, Pann-Ghill, Yoo, HS   +5 more
core