Results 81 to 90 of about 9,343 (242)

Sphingolipids as emerging mediators in retina degeneration [PDF]

, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber, Rotstein, Nora Patricia, Simon, Maria Victoria, Vera, Marcela Sonia   +3 more
core   +1 more source

Early Childhood Dietary Exposure of Aflatoxins and Fumonisins in Tanzania: Role in Child Stunting and Possible Interventions (2003–2024)

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Childhood stunting is a major public health concern, and dietary exposure to aflatoxins and fumonisins during early life is associated with child stunting in Tanzania. The causal link between aflatoxin and/or fumonisin exposure and child stunting has been less well explained.
Clara Mollay
wiley   +1 more source

Metabolic profiles in community-acquired pneumonia: developing assessment tools for disease severity

Critical Care, 2018
Background This study aimed to determine whether community-acquired pneumonia (CAP) had a metabolic profile and whether this profile can be used for disease severity assessment.
Pu Ning, Yali Zheng, Qiongzhen Luo, Xiaohui Liu, Yu Kang, Yan Zhang, Rongbao Zhang, Yu Xu, Donghong Yang, Wen Xi, Keqiang Wang, Yusheng Chen, Shuchang An, Zhancheng Gao   +13 more
doaj   +1 more source

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota [PDF]

, 2013
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified.
Bluestone, Jeffrey A., Clardy, Jon, Comstock, Laurie E., Fischbach, Michael A., Kashyap, Purna C., Kronenberg, Mitchell, Penaranda, Cristina, Sonnenburg, Justin L., Wieland Brown, Laura C., Williams, Brianna B.   +9 more
core   +4 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether [PDF]

, 2016
Long-chain bases (LCBs) are the precursors to ceramide and sphingolipids in eukaryotic cells. They are formed by the action of serine palmitoyl-CoA transferase (SPT), a complex of integral membrane proteins located in the endoplasmic reticulum.
Hsu, Fong-Fu, Lone, Museer A., Martínez-Montañés, Fernando, Schneiter, Roger   +3 more
core   +2 more sources

Trifunctional sphinganine: a new tool to dissect sphingolipid function [PDF]

, 2023
Scotland Farley, Frank Stein, Per Haberkant, Fikadu Tafesse, Carsten Schultz   +4 more
openalex   +1 more source

Overexpression of the Tomato Asc-1 Gene Mediates High Insensitivity to AAL Toxins and Fumonisin B1 in Tomato Hairy Roots and Confers Resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica Plants

Molecular Plant-Microbe Interactions, 2002
The sphinganine-analog mycotoxins (SAMs) fumonisin B1 and AAL toxins are inhibitors of eukaryotic sphinganine N-acyltransferase in vitro. Treatment of eukaryotes with SAMs generally results in an accumulation of sphingoid base precursors and a depletion ...
Bas F. Brandwagt, Tarcies J. A. Kneppers, H. John J. Nijkamp, Jacques Hille   +3 more
doaj   +1 more source

Fumonisin B-Glucose Reaction Products Are Less Toxic When Fed to Swine [PDF]

, 2005
The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 µmol of total fumonisin B/kg (FB), 528 µmol of total FB-glucose adducts/kg (FB-G, 122 µmol of unreacted FB/kg), or 0 µmol of total FB/kg ...
Buckley, Lucas, Fernandez-Surumay, Guillermo, Hendrich, Suzanne, Hendrich, Suzanne, Murphy, Patricia, Osweiler, Gary, Rottinghaus, George, Yaeger, Michael   +7 more
core   +3 more sources

Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum

Journal of Chromatography B: Biomedical Sciences and Applications, 1998
The fumonisin mycotoxins, which are worldwide contaminants of corn, inhibit de novo sphingolipid biosynthesis leading to elevation in the ratio of the sphingoid bases, sphinganine and sphingosine, in the serum of animals exposed to fumonisins. A new HPLC method for the determination of the ratio of these bases in serum has been developed involving ...
Shephard, Gordon Seymour, van der Westhuizen, L   +1 more
openaire   +3 more sources