Results 161 to 170 of about 46,072 (254)

Loss of ceramide synthases 5 and 6 exacerbate myristate-induced colonic IRE1α activation. [PDF]

J Lipid Res
Doll CL, Gordon MR, Padilla-Rodriguez M, Jap E, Boasiako PA, Marron MT, Dahl BK, Espinoza KS, Seiser DM, Ren RJ, Thorne CA, Snider JM, Snider AJ.   +12 more
europepmc   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Sphingolipid Metabolism: A Pathological Hub Linking Lipid Dysregulation and Chronic Inflammation in Atherosclerotic Cardiovascular Disease. [PDF]

J Inflamm Res
Wang S, Dong Y, Li X, Dong R, Jing L.
europepmc   +1 more source

Functional Characterization and Application of Yarrowia lipolytica YlYxc1 for Enhanced Production of Sphingoid Bases. [PDF]

Microb Biotechnol
YlYxc1, an ER‐associated alkaline ceramidase of Yarrowia lipolytica, has the hydrolytic activity of ceramides, which can be exploited as a metabolic engineering target to enhance long‐chain base production. ABSTRACT Long‐chain bases (LCBs; sphingoid bases), derived from ceramide metabolism, are valuable sphingolipid intermediates for industrial ...
Shin SH, Jeon EJ, Moon HY, Go GY, Yoo YS, Lee JK, Jeon CO, Kang HA.   +7 more
europepmc   +2 more sources

Metabolic pattern across energy imbalance: An exploratory metabolomics study of female body weight extremes including anorexia nervosa and athletes

Experimental Physiology, EarlyView.
Abstract In anorexia nervosa (AN), prolonged metabolic adaptation to severe energy deficiency can impair treatment efficacy. Similarly, low energy availability poses a recognized risk to athletes, potentially compromising health and performance. This cross‐sectional study aimed to characterize the plasma metabolic pattern of females with varying ...
Sonja Lackner, Olli Kärkkäinen, Sabrina Mörkl, Wolfram Müller, Alfred Fürhapter‐Rieger, Kati Hanhineva, Sandra Johanna Holasek   +6 more
wiley   +1 more source

The riddle of sphingolipid structure-function relationship in the nervous system. [PDF]

J Biol Chem
Muñoz-Gil S, Spassieva SD.
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Sphingolipids associated research in Alzheimer's disease: an explored trends analysis. [PDF]

Front Aging Neurosci
Xie MR, Chen YJ, Yuan H.
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Sphingolipid Dysregulation in Impaired Spermatogenesis: Azoospermic Mouse Model. [PDF]

Int J Fertil Steril
Parvini M, Ghasemian F, Salimy S.
europepmc   +1 more source