Results 261 to 270 of about 41,788 (297)
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Cancer and Metastasis Reviews, 2011
The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-phosphate (S1P) have important roles in several types of signaling and regulation of many cellular processes including cell proliferation, apoptosis, senescence, angiogenesis, and transformation. Recent accumulating evidence suggests that ceramide- and S1P-mediated pathways
Hideki, Furuya +2 more
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The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-phosphate (S1P) have important roles in several types of signaling and regulation of many cellular processes including cell proliferation, apoptosis, senescence, angiogenesis, and transformation. Recent accumulating evidence suggests that ceramide- and S1P-mediated pathways
Hideki, Furuya +2 more
openaire +2 more sources
Biochemistry (Moscow), 2008
The role of sphingolipids as receptors of bacteria, viruses, and toxins and also as ligands of proteinaceous receptors involved in the cell-cell signaling in animals is considered.
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The role of sphingolipids as receptors of bacteria, viruses, and toxins and also as ligands of proteinaceous receptors involved in the cell-cell signaling in animals is considered.
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The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases
2013The relationship of sphingolipids with human disease first arose from the study of sphingolipid storage diseases over 50 years ago. Most of these disorders are due to inherited deficiencies of specific sphingolipid hydrolases, although a small number also result from defects in sphingolipid transport or activator proteins.
Edward H, Schuchman +1 more
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2023
Sphingolipids are a class of lipids containing the backbone of long-chain amino-alcohol bases in their structure, which are synthesized in the endoplasmic reticulum. Modification of this base gives rise to a variety of such lipids ranging from simple to complex sphingolipids that play a significant structural and functional role in membrane biology as ...
Shaista Nosheen +3 more
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Sphingolipids are a class of lipids containing the backbone of long-chain amino-alcohol bases in their structure, which are synthesized in the endoplasmic reticulum. Modification of this base gives rise to a variety of such lipids ranging from simple to complex sphingolipids that play a significant structural and functional role in membrane biology as ...
Shaista Nosheen +3 more
openaire +1 more source
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
Science, 1989The discovery that breakdown products of cellular sphingolipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction.
Y A, Hannun, R M, Bell
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Sphingolipids in inflammatory hypoxia
Biological Chemistry, 2018Abstract Hypoxia due to rapid tumor growth with impaired neovascularization and inflammation resulting from immune cell activation are hallmarks of cancer. Hypoxia-inducible factors control transcriptional adaptation in response to low oxygen conditions, both in tumor and immune cells.
Glaser, Ulrike G, Fandrey, Joachim
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Sphingolipids in food and their critical roles in human health
Critical Reviews in Food Science and Nutrition, 2021Xiaoxu Wang, Yuming Wang, Changhu Xue
exaly