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Neurodegenerative Disorders: Spotlight on Sphingolipids

open access: yesInternational Journal of Molecular Sciences, 2021
Neurodegenerative diseases are incurable diseases of the nervous system that lead to a progressive loss of brain areas and neuronal subtypes, which is associated with an increase in symptoms that can be linked to the affected brain areas.
Melissa Voß, Frida Mandik
exaly   +2 more sources
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Sphingolipids and Cholesterol

2022
Sphingolipids and cholesterol are two lipid partners on cellular membranes where they form specific microdomains, named lipid rafts, which mediate specific cell functions. Sphingomyelin (SM) is one of the major sphingolipids. SM and free cholesterol are also two key lipids on the monolayer of plasma lipoproteins, including chylomicron, very low-density
Xian-Cheng, Jiang, Zhiqiang, Li
openaire   +2 more sources

Sphingolipids as therapeutics

Pharmacological Research, 2003
The sphingolipid field has made significant strides over the past 10 years: from identifying metabolites of the sphingomyelin pathway as second messengers to discerning the molecular biology and biophysics of these lipid-derived second messengers. Building upon this vast basic science literature, scientists from multiple disciplines have begun to ...
Mark, Kester, Richard, Kolesnick
openaire   +2 more sources

Sphingolipids in the Lungs

American Journal of Respiratory and Critical Care Medicine, 2008
Abstract Sphingolipids such as sphingosine-1-phosphate (S1P), ceramide, or sphingomyelin are essential constituents of plasma membranes and regulate many (patho)physiological cellular responses inducing apoptosis and cell survival, vascular permeability, mast cell activation, and airway smooth muscle functions.
Stefan, Uhlig, Erich, Gulbins
openaire   +2 more sources

CHEMISTRY OF THE SPHINGOLIPIDES

Canadian Journal of Biochemistry and Physiology, 1956
Chemical studies leading to the elucidation of the structures of sphingosine, cerebrosides, sphingomyelin, and cerebroside sulphuric acid are reviewed. The general nature of the complex sphingolipides (ganglioside, hematoside, globoside, strandin, polycerebroside) is discussed.
H E, CARTER, D S, GALANOS, Y, FUJINO
openaire   +2 more sources

Yeast sphingolipids

Biochimica et Biophysica Acta (BBA) - General Subjects, 1999
Many advances in our understanding of fungal sphingolipids have been made in recent years. This review focuses on the types of sphingolipids that have been found in fungi and upon the genes in Saccharomyces cerevisiae, the common baker's yeast, that are necessary for sphingolipid metabolism.
R C, Dickson, R L, Lester
openaire   +2 more sources

Sphingolipids and Asthma

2022
Asthma is the most prevalent chronic respiratory disease worldwide and the leading serious chronic illness in children. Clinical characteristics are wheezing, reversible airway obstruction, airway inflammation, and airway hyperreactivity. Asthma susceptibility is influenced by genes and environment.
openaire   +2 more sources

Sphingolipids in cancer

Cancer and Metastasis Reviews, 2011
The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-phosphate (S1P) have important roles in several types of signaling and regulation of many cellular processes including cell proliferation, apoptosis, senescence, angiogenesis, and transformation. Recent accumulating evidence suggests that ceramide- and S1P-mediated pathways
Hideki, Furuya   +2 more
openaire   +2 more sources

Sphingolipid Transport

2010
Sphingolipids are a family of ubiquitous membrane components that exhibit multiple functional properties fundamental to cell properties. Sphingolipid transport represents a crucial aspect in the metabolism, signaling and biological role of sphingolipids.
L. Riboni, P. Giussani, P. Viani
openaire   +2 more sources

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